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Query: BIRC2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BIRC2 0 1.623 -0.730 0.440

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BIRC2 Ubiquitylation K410 0.878 _DLVK(gl)QTVQSK_
BIRC2 Ubiquitylation K490 0.305 0.534 _ANVINK(gl)QEHDIIK_
BIRC2 Ubiquitylation K15 -0.259 0.307 _(ac)MEDSTILSDWTNSNK(gl)QK_
BIRC2 Ubiquitylation K17 -0.259 0.307 _(ac)MEDSTILSDWTNSNK(gl)QK_
BIRC2 Ubiquitylation K102 -1.755 _LGDSPIQK(gl)HK_
BIRC2 Ubiquitylation K38 -0.069 _SIMEDSTILSDWTNSNKQK(gl)_
BIRC2 Ubiquitylation K233 -0.511 _LSNWEPK(gl)DDAMSEHR_
BIRC2 Ubiquitylation K497 -1.934 _ANVINKQEHDIIK(gl)QK_

Background Information for BIRC2:


Pubmed-BIRC2 »
Uniprot-BIRC2 »
Biogrid-BIRC2 »
ProteomicsDB-BIRC2 »

Tumorportal-BIRC2 »
COSMIC-BIRC2 »
GenomeRNAi-BIRC2 »
Genecards-BIRC2


Protein-protein Interactions for BIRC2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAMTS4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BIRC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BIRC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C1R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLEC11A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DIABLO Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAJB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR107 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPIN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LTBR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRDX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RABGEF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPINK7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAS2R7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM9B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VPS4B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDYHV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFAND6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BIRC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DEATH-like_dom IPR011029 1.15
Category members CARD IPR001315 0.55
Category members BIR IPR001370 0.04
Category members Znf_RING IPR001841 0


Protein complexes (CORUM database) featuring BIRC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5529 TRAF2-cIAP1/BIRC2 complex Database 0
Category members Corum 5531 Tumor necrosis factor receptor 1 signaling complex Database 0


Categories featuring BIRC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0001741 XY body Database 0.47
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members Pathway Pathway_1053 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0007166 cell surface receptor signaling pathway Database 0.1
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Pathway Pathway_1056 REACTOME_NOD1_2_SIGNALING_PATHWAY 0 0.04
Category members GO Category GO:0010243 response to organonitrogen compound Database 0.02
Category members Pathway Pathway_965 BIOCARTA_CASPASE_PATHWAY 0 0.01
Category members Pathway Pathway_1012 BIOCARTA_MITOCHONDRIA_PATHWAY 0 0
Category members Pathway Pathway_1020 BIOCARTA_DEATH_PATHWAY 0 0
Category members Pathway Pathway_1021 ST_TUMOR_NECROSIS_FACTOR_PATHWAY 0 0
Category members Pathway Pathway_1051 PID_NFKAPPAB_CANONICAL_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_650 PID_FAS_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_959 SA_CASPASE_CASCADE 0 0
Category members Pathway Pathway_986 PID_CD40_PATHWAY 0 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001890 placenta development Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0009898 cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0034121 regulation of toll-like receptor signaling pathway Database 0
Category members GO Category GO:0035631 CD40 receptor complex Database 0
Category members GO Category GO:0038061 NIK/NF-kappaB signaling Database 0
Category members GO Category GO:0039535 regulation of RIG-I signaling pathway Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0045088 regulation of innate immune response Database 0
Category members GO Category GO:0045595 regulation of cell differentiation Database 0
Category members GO Category GO:0050727 regulation of inflammatory response Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0
Category members GO Category GO:0051591 response to cAMP Database 0
Category members GO Category GO:0060544 regulation of necroptotic process Database 0
Category members GO Category GO:0070266 necroptotic process Database 0
Category members GO Category GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway Database 0


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