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Query: CASP2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CASP2 0 -1.876 0.980 -1.120

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CASP2 Phosphorylation S340 -0.347 -1.529 _NHAGS(ph)PGCEESDAGKEK_

Background Information for CASP2:


Pubmed-CASP2 »
Uniprot-CASP2 »
Biogrid-CASP2 »
ProteomicsDB-CASP2 »

Tumorportal-CASP2 »
COSMIC-CASP2 »
GenomeRNAi-CASP2 »
Genecards-CASP2


Protein-protein Interactions for CASP2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BBOX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HNRNPK Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CASP2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DEATH-like_dom IPR011029 1.15
Category members CARD IPR001315 0.55
Category members Pept_C14_ICE_p20 IPR001309 0.07
Category members Pept_C14_caspase IPR011600 0.07
Category members Pept_C14A_p45_core IPR015917 0.04
Category members Pept_C14_p10 IPR002138 0
Category members Caspase_ICE-type IPR017350 0


Protein complexes (CORUM database) featuring CASP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 129 PIDDsome complex Database 0


Categories featuring CASP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Database 1.39
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0016485 protein processing Database 0.57
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members GO Category GO:0004197 cysteine-type endopeptidase activity Database 0.38
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_1015 PID_HIV_NEF_PATHWAY 0 0.15
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members Pathway Pathway_1056 REACTOME_NOD1_2_SIGNALING_PATHWAY 0 0.04
Category members Pathway Pathway_965 BIOCARTA_CASPASE_PATHWAY 0 0.01
Category members Pathway Pathway_1046 BIOCARTA_STRESS_PATHWAY 0 0
Category members Disease phenotype Autosomal_Recessive_Mental_Retardation Autosomal Recessive Mental Retardation Database 0
Category members GO Category GO:0001554 luteolysis Database 0
Category members GO Category GO:0003407 neural retina development Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0008234 cysteine-type peptidase activity Database 0
Category members GO Category GO:0035234 germ cell programmed cell death Database 0
Category members GO Category GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0
Category members GO Category GO:0071260 cellular response to mechanical stimulus Database 0


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