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Query: CYCS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CYCS 0 -1.699 -0.020 -0.350 0.711 0.320

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CYCS Ubiquitylation K101 -1.859 _ADLIAYLKK(gl)_
CYCS Ubiquitylation K54 -0.872 -1.922 _K(gl)TGQAPGYSYTAANK(gl)NK_
CYCS Ubiquitylation K56 -0.872 -1.922 _TGQAPGYSYTAANKNK(gl)_
CYCS Ubiquitylation K40 -2.265 _K(gl)TGQAPGYSYTAANK(gl)NK_

Background Information for CYCS:


Pubmed-CYCS »
Uniprot-CYCS »
Biogrid-CYCS »
ProteomicsDB-CYCS »

Tumorportal-CYCS »
COSMIC-CYCS »
GenomeRNAi-CYCS »
Genecards-CYCS


Protein-protein Interactions for CYCS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LRG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CYCS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cyt_c-like_dom IPR009056 0


Protein complexes (CORUM database) featuring CYCS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1248 Apoptosome Database 0
Category members Corum 5816 Apoptosome-procaspase 9 complex Database 0


Categories featuring CYCS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members Pathway Pathway_50 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ 0 0.7
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members GO Category GO:0070469 respiratory chain Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0005758 mitochondrial intermembrane space Database 0.33
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0006309 apoptotic DNA fragmentation Database 0.26
Category members Pathway Pathway_964 BIOCARTA_CHEMICAL_PATHWAY 0 0.24
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members Pathway Pathway_49 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT 0 0.17
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members GO Category GO:0022904 respiratory electron transport chain Database 0.15
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members Pathway Pathway_1015 PID_HIV_NEF_PATHWAY 0 0.15
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members Disease phenotype Autosomal_thrombocytopenia_with_normal_platelets Autosomal thrombocytopenia with normal platelets Database 0.08
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Pathway Pathway_13 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0 0.04
Category members GO Category GO:0005506 iron ion binding Database 0.04
Category members GO Category GO:0020037 heme binding Database 0.04
Category members GO Category GO:0009055 electron carrier activity Database 0.02
Category members Pathway Pathway_617 BIOCARTA_TFF_PATHWAY 0 0.02
Category members Pathway Pathway_965 BIOCARTA_CASPASE_PATHWAY 0 0.01
Category members Pathway Pathway_1012 BIOCARTA_MITOCHONDRIA_PATHWAY 0 0
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1017 BIOCARTA_HSP27_PATHWAY 0 0
Category members Pathway Pathway_1020 BIOCARTA_DEATH_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_31 KEGG_PARKINSONS_DISEASE 0 0
Category members Pathway Pathway_48 BIOCARTA_ETC_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_737 BIOCARTA_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_966 BIOCARTA_D4GDI_PATHWAY 0 0
Category members Pathway Pathway_990 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0
Category members GO Category GO:0000159 protein phosphatase type 2A complex Database 0
Category members GO Category GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Database 0
Category members GO Category GO:0045333 cellular respiration Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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