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Query: LMNA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LMNA 1 8.229 0.760 -0.400 1.025 -0.121 0.091 1.281 0.818

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LMNA Ubiquitylation K233 0.194 1.930 _LVEIDNGK(gl)QREFESR_
LMNA Phosphorylation S636 0.537 1.498 _SVGGSGGGS(ph)FGDNLVTR_
LMNA Ubiquitylation K135 0.856 1.129 _LK(gl)DLEALLNSK_
LMNA Ubiquitylation K311 0.853 0.977 _IDSLSAQLSQLQK(gl)QLAAK_
LMNA Ubiquitylation K270 0.362 0.777 _TYSAK(gl)LDNAR_
LMNA Ubiquitylation K180 0.977 0.753 _LEAALGEAK(gl)K_
LMNA Ubiquitylation K265 0.532 0.714 _ELEK(gl)TYSAK_
LMNA Ubiquitylation K378 -0.030 0.701 _K(gl)LLEGEEER_
LMNA Ubiquitylation K181 0.458 0.679 _K(gl)QLQDEMLR_
LMNA Phosphorylation S403 0.641 _GRAS(ph)SHSSQTQGGGSVTK_
LMNA Phosphorylation S458 0.520 _NKS(ph)NEDQSMGNWQIK_
LMNA Ubiquitylation K219 0.784 0.456 _NIYSEELRETK(gl)R_
LMNA Ubiquitylation K171 0.656 0.450 _GQVAK(gl)LEAALGEAKK_
LMNA Phosphorylation S22 -0.433 0.377 _SGAQASST(ph)PLS(ph)PTR_
LMNA Ubiquitylation K155 -0.218 0.375 _EAALSTALSEK(gl)R_
LMNA Phosphorylation S392 -0.062 -0.026 _LSPS(ph)PTSQR_
LMNA Phosphorylation S390 -0.020 -0.112 _LRLS(ph)PSPTSQR_
LMNA Ubiquitylation K97 0.499 -0.167 _TLDSVAK(gl)ER_
LMNA Phosphorylation T19 -1.262 _SGAQASST(ph)PLS(ph)PTR_
LMNA Ubiquitylation K32 0.054 _LQEK(gl)EDLQELNDR_
LMNA Ubiquitylation K78 -0.306 _EVSGIK(gl)AAYEAELGDAR_
LMNA Ubiquitylation K108 0.586 _LQLELSK(gl)VR_
LMNA Ubiquitylation K114 0.753 _VREEFK(gl)ELK_
LMNA Ubiquitylation K117 0.571 _VREEFKELK(gl)AR_
LMNA Ubiquitylation K122 0.401 _NTK(gl)KEGDLIAAQAR_
LMNA Ubiquitylation K123 0.401 _NTK(gl)KEGDLIAAQAR_
LMNA Ubiquitylation K261 0.576 _AQHEDQVEQYKK(gl)ELEK_
LMNA Phosphorylation S632 0.730 _SVGGS(ph)GGGSFGDNLVTR_

Background Information for LMNA:


Pubmed-LMNA »
Uniprot-LMNA »
Biogrid-LMNA »
ProteomicsDB-LMNA »

Tumorportal-LMNA »
COSMIC-LMNA »
GenomeRNAi-LMNA »
Genecards-LMNA


Protein-protein Interactions for LMNA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CENPE Cat. description Hein, Mann, Cell 2015
Category members IP bait LMNA Cat. description Hein, Mann, Cell 2015
Category members IP bait TMPO Cat. description Hein, Mann, Cell 2015
Category members IP bait SUN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LMNA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Lamin_tail_dom IPR001322 0.9
Category members IF IPR001664 0
Category members Prefoldin IPR009053 0


Protein complexes (CORUM database) featuring LMNA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5611 Emerin complex 24 Database 1.05
Category members Corum 1728 CTCF-nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex Database 0.63
Category members Corum 5608 Emerin architectural complex Database 0.15


Categories featuring LMNA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0007077 mitotic nuclear envelope disassembly Database 5.8
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0005652 nuclear lamina Database 1.08
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members GO Category GO:0005638 lamin filament Database 0.89
Category members Disease phenotype Autosomal_dominant_Emery-Dreifuss_muscular_dystrophy Autosomal dominant Emery-Dreifuss muscular dystrophy Database 0.89
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0030334 regulation of cell migration Database 0.61
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members GO Category GO:0006998 nuclear envelope organization Database 0.4
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0007084 mitotic nuclear envelope reassembly Database 0.24
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0006997 nucleus organization Database 0.18
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members GO Category GO:0034504 protein localization to nucleus Database 0.15
Category members Pathway Pathway_148 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S 0 0.11
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_biventricular_form Familial isolated arrhythmogenic ventricular dysplasia biventricular form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_left_dominant_form Familial isolated arrhythmogenic ventricular dysplasia left dominant form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_right_dominant_form Familial isolated arrhythmogenic ventricular dysplasia right dominant form Database 0.05
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members Pathway Pathway_965 BIOCARTA_CASPASE_PATHWAY 0 0.01
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1020 BIOCARTA_DEATH_PATHWAY 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Disease phenotype HUTCHINSON-GILFORD_PROGERIA_SYNDROME HUTCHINSON-GILFORD PROGERIA SYNDROME Database 0
Category members Disease phenotype Left_ventricular_noncompaction Left ventricular noncompaction Database 0
Category members Disease phenotype Lethal_restrictive_dermopathy Lethal restrictive dermopathy Database 0
Category members Disease phenotype RESTRICTIVE_DERMOPATHY_LETHAL RESTRICTIVE DERMOPATHY LETHAL Database 0
Category members GO Category GO:0005882 intermediate filament Database 0
Category members GO Category GO:0007517 muscle organ development Database 0
Category members GO Category GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity Database 0
Category members GO Category GO:0055015 ventricular cardiac muscle cell development Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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