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Query: PARP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PARP1 2 5.694
PARP1 2 5.694 -0.200 0.357 0.412 0.442 0.293

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PARP1 Ubiquitylation K131 1.025 1.620 _GCMEK(gl)IEK_
PARP1 Ubiquitylation K683 0.983 1.355 _MIFDVESM(ox)K(gl)K_
PARP1 Ubiquitylation K684 1.213 1.355 _MIFDVESMKK(gl)_
PARP1 Ubiquitylation K414 1.227 1.241 _AMIEK(gl)LGGK_
PARP1 Ubiquitylation K197 0.445 1.157 _K(gl)QLPGVK_
PARP1 Ubiquitylation K400 0.844 1.095 _ILTLGK(gl)LSR_
PARP1 Ubiquitylation K320 1.464 1.034 _SDAYYCTGDVTAWTK(gl)CMVK_
PARP1 Ubiquitylation K425 0.912 0.815 _LTGTANK(gl)ASLCISTKK_
PARP1 Phosphorylation S782 0.648 0.490 _GGS(ph)DDSSKDPIDVNYEK_
PARP1 Ubiquitylation K346 0.370 0.411 _EISYLK(gl)K_
PARP1 Ubiquitylation K97 1.386 0.406 _TAEAGGVTGK(gl)GQDGIGSK_
PARP1 Ubiquitylation K337 0.462 0.332 _EWVTPK(gl)EFR_
PARP1 Ubiquitylation K633 0.964 0.091 _NFTK(gl)YPK_
PARP1 Ubiquitylation K434 0.020 _ASLCISTKK(gl)_
PARP1 Ubiquitylation K664 -0.042 -0.111 _LTVNPGTKSK(gl)_
PARP1 Ubiquitylation K331 -0.425 -0.480 _TQTPNRK(gl)EWVTPK_
PARP1 Ubiquitylation K548 0.125 -0.480 _GGAAVDPDSGLEHSAHVLEK(gl)GGK_
PARP1 Ubiquitylation K551 0.492 -0.573 _GGAAVDPDSGLEHSAHVLEKGGK(gl)_
PARP1 Phosphorylation S41 -0.803 _MAIMVQS(ph)PMFDGK_
PARP1 Phosphorylation T368 -1.474 -1.410 _IFPPETSASVAAT(ph)PPPSTASAPAAVNSSASADKPLSNM(ox)K_
PARP1 Ubiquitylation K84 1.223 _WDDQQK(gl)VK_
PARP1 Ubiquitylation K86 1.058 _VK(gl)KTAEAGGVTGK_
PARP1 Ubiquitylation K87 1.058 _VK(gl)KTAEAGGVTGK_
PARP1 Ubiquitylation K105 0.828 _GQDGIGSK(gl)AEK_
PARP1 Ubiquitylation K108 1.317 _GQDGIGSKAEK(gl)_
PARP1 Ubiquitylation K119 1.569 _TLGDFAAEYAK(gl)SNR_
PARP1 Ubiquitylation K254 0.589 _AQNDLIWNIKDELKK(gl)_
PARP1 Ubiquitylation K262 0.456 _VCSTNDLK(gl)ELLIFNK_
PARP1 Ubiquitylation K418 1.131 _LGGK(gl)LTGTANK_
PARP1 Ubiquitylation K433 0.942 _ASLCISTK(gl)K_
PARP1 Ubiquitylation K447 1.480 _MEEVK(gl)EANIR_
PARP1 Ubiquitylation K518 0.108 _GQVKEEGINK(gl)SEK_
PARP1 Ubiquitylation K521 0.630 _GQVKEEGINKSEK(gl)R_
PARP1 Ubiquitylation K629 1.632 _TGNAWHSK(gl)NFTK_
PARP1 Ubiquitylation K654 -0.086 _K(gl)LTVNPGTK_
PARP1 Ubiquitylation K662 0.112 _LTVNPGTK(gl)SK_
PARP1 Ubiquitylation K700 0.448 _MPLGK(gl)LSK_
PARP1 Ubiquitylation K949 0.738 _HSVK(gl)GLGK_

Background Information for PARP1:


Pubmed-PARP1 »
Uniprot-PARP1 »
Biogrid-PARP1 »
ProteomicsDB-PARP1 »

Tumorportal-PARP1 »
COSMIC-PARP1 »
GenomeRNAi-PARP1 »
Genecards-PARP1


Protein-protein Interactions for PARP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATRX Cat. description Hein, Mann, Cell 2015
Category members IP bait BRWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait DAXX Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3I Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC1;RP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait TIMELESS Cat. description Hein, Mann, Cell 2015
Category members IP bait APLF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHD1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MACROD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF146 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF166 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR76 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XPC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XRCC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PARP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BRCT_dom IPR001357 1.59
Category members Znf_PARP IPR001510 0.35
Category members WGR_domain IPR008893 0.03
Category members Poly(ADP-ribose)pol_reg_dom IPR004102 0
Category members Poly(ADP-ribose)pol_cat_dom IPR012317 0


Protein complexes (CORUM database) featuring PARP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3137 MASH1 promoter-coactivator complex Database 5.32
Category members Corum 1193 Rap1 complex Database 2.66
Category members Corum 1226 H2AX complex I Database 1.58
Category members Corum 3135 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.58
Category members Corum 1729 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.02
Category members Corum 1004 RC complex during S-phase of cell cycle Database 0.79
Category members Corum 5179 NCOA6-DNA-PK-Ku-PARP1 complex Database 0.7
Category members Corum 1005 RC complex during G2/M-phase of cell cycle Database 0.67
Category members Corum 1728 CTCF-nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex Database 0.63
Category members Corum 5235 WRN-Ku70-Ku80-PARP1 complex Database 0.31
Category members Corum 159 Condensin I-PARP-1-XRCC1 complex Database 0.12
Category members Corum 3142 CAMK2-delta-MASH1 promoter-coactivator complex Database 0.07
Category members Corum 2625 CDK8-MED6-PARP1 complex Database 0


Categories featuring PARP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members GO Category GO:0051287 NAD binding Database 1.6
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_964 BIOCARTA_CHEMICAL_PATHWAY 0 0.24
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0070212 protein poly-ADP-ribosylation Database 0.11
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members GO Category GO:0023019 signal transduction involved in regulation of gene expression Database 0.08
Category members Pathway Pathway_823 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY 0 0.07
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members Pathway Pathway_517 ST_GRANULE_CELL_SURVIVAL_PATHWAY 0 0.02
Category members Pathway Pathway_965 BIOCARTA_CASPASE_PATHWAY 0 0.01
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_959 SA_CASPASE_CASCADE 0 0
Category members Pathway Pathway_966 BIOCARTA_D4GDI_PATHWAY 0 0
Category members Disease phenotype Autosomal_Recessive_Mental_Retardation Autosomal Recessive Mental Retardation Database 0
Category members GO Category GO:0003950 NAD+ ADP-ribosyltransferase activity Database 0
Category members GO Category GO:0006259 DNA metabolic process Database 0
Category members GO Category GO:0006471 protein ADP-ribosylation Database 0
Category members GO Category GO:0016540 protein autoprocessing Database 0
Category members GO Category GO:0030225 macrophage differentiation Database 0
Category members GO Category GO:0040009 regulation of growth rate Database 0
Category members GO Category GO:0042769 DNA damage response, detection of DNA damage Database 0
Category members GO Category GO:0060391 positive regulation of SMAD protein import into nucleus Database 0
Category members GO Category GO:0070412 R-SMAD binding Database 0


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