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REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS
(Pathway_559)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
TRIM24 2 0.580 -0.300 -1.173 -0.067 -0.484 -0.364
PLCG1 1 -0.170 0.000
FGFR1OP 1 -0.600 0.800
CPSF6 0 -0.660 0.180 1.002 0.250 0.499 0.312 -0.256
STAT1 0 -0.550 0.170
ZMYM2 0 0.460 -0.090 -1.246 -0.344 0.249 -0.226 -0.259
PIK3CA 0
PIK3R1 0 1.910 -1.220 -0.441 0.147
STAT3 0 0.200 -1.270 0.334
STAT5B 0 0.670 -0.960
GRB2 0 -0.240 0.300 -1.021 0.057 0.906
BCR 0 -0.110 -0.410
BCR 0 0.680 -0.700
BCR 0 -0.110 -0.410 1.326
BCR 0 0.680 -0.700 1.326
MYO18A 0 0.100 -0.380 0.610 0.207

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
BCR Phosphorylation S122 -1.850 -1.388 _ASASRPQPAPADGADPPPAEEPEARPDGEGS(ph)PGK_
BCR Phosphorylation S354 -0.057 0.015 _VS(ph)PSPTTYR_
BCR Phosphorylation S459 -0.638 -0.740 _HQDGLPYIDDS(ph)PSSSPHLSSK_
BCR Phosphorylation S1035 0.931 1.055 _LSVKFNS(ph)R_
BCR Ubiquitylation K1066 0.971 _SK(gl)VPYIVR_
CPSF6 Ubiquitylation K79 -0.081 _GAAPNVVYTYTGK(gl)R_
CPSF6 Ubiquitylation K138 0.018 _GFALVGVGSEASSK(gl)K_
CPSF6 Ubiquitylation K139 -0.782 _GFALVGVGSEASSKK(gl)_
CPSF6 Ubiquitylation K185 -0.516 -0.824 _TTQSGQMSGEGK(gl)AGPPGGSSR_
CPSF6 Phosphorylation T404 1.179 1.083 _EMDT(ph)ARTPLSEAEFEEIMNR_
CPSF6 Phosphorylation T407 1.386 1.306 _EMDTART(ph)PLSEAEFEEIMNR_
FGFR1OP Phosphorylation S156 -0.647 -0.663 _EKGPTTGEGALDLSDVHS(ph)PPKS(ph)PEGK_
FGFR1OP Phosphorylation S160 -0.079 -0.321 _EKGPTTGEGALDLSDVHS(ph)PPKS(ph)PEGK_
FGFR1OP Phosphorylation T170 -0.492 -1.069 _TSAQTT(ph)PSKIPR_
FGFR1OP Phosphorylation S326 1.712 _IGS(ph)LGLGTGEDDDYVDDFNSTSHR_
GRB2 Ubiquitylation K10 0.146 _YDFK(gl)ATADDELSFK_
GRB2 Ubiquitylation K20 -0.078 _ATADDELSFK(gl)R_
GRB2 Ubiquitylation K69 -0.362 0.641 _AK(gl)AEEMLSK_
GRB2 Ubiquitylation K76 0.754 _AEEMLSK(gl)QR_
GRB2 Ubiquitylation K109 0.381 -0.002 _FGNDVQHFK(gl)VLR_
MYO18A Phosphorylation S140 0.894 0.905 _RFS(ph)FSQR_
MYO18A Phosphorylation S728 -0.154 -0.108 _STS(ph)FRQGPEESGLGDGTGPK_
MYO18A Phosphorylation S2020 -0.376 _SLAPDRS(ph)DDEHDPLDNTSRPR_
PIK3CA Ubiquitylation K864 0.390 0.588 _NSHTIM(ox)QIQCK(gl)GGLK_
PIK3CA Ubiquitylation K868 0.204 0.651 _NSHTIM(ox)QIQCKGGLK(gl)_
PIK3CA Ubiquitylation K974 -0.273 _GAQECTK(gl)TREFER_
PLCG1 Ubiquitylation K300 8.031 _DLK(gl)NMLSQVNYR_
PLCG1 Ubiquitylation K348 -0.219 _SLMYSAQK(gl)TMDLPFLEASTLR_
PLCG1 Ubiquitylation K552 -0.355 _NMAQYFK(gl)K_
PLCG1 Ubiquitylation K553 -0.355 _NMAQYFK(gl)K_
PLCG1 Ubiquitylation K1063 0.864 0.355 _LTEGK(gl)IMER_
PLCG1 Phosphorylation S1370 0.475 0.515 _AREGS(ph)FESR_
STAT1 Phosphorylation S727 1.377 0.974 _LQTTDNLLPMS(ph)PEEFDEVSR_
STAT3 Ubiquitylation K177 0.957 _VVENLQDDFDFNYK(gl)TLK_
STAT3 Ubiquitylation K180 1.179 _TLK(gl)SQGDMQDLNGNNQSVTR_
STAT3 Ubiquitylation K244 0.262 _TLTDEELADWK(gl)R_
STAT3 Phosphorylation T714 -0.338 _FICVT(ph)PTTCSNTIDLPMS(ph)PR_
STAT3 Phosphorylation S727 -0.079 0.156 _FICVTPTTCSNTIDLPMS(ph)PR_
STAT5B Phosphorylation S194 0.270 _IQAQFGPLAQLS(ph)PQER_
TRIM24 Ubiquitylation K303 0.293 _IIEVNQNQK(gl)QVEQDIK_
TRIM24 Ubiquitylation K341 1.339 _MK(gl)LMQQQQEVAGLSK_
TRIM24 Phosphorylation S660 -0.300 _TVQS(ph)PNSSVPSPGLAGPVTMTSVHPPIR_
TRIM24 Phosphorylation S768 2.572 _SILTSLLLNSS(ph)QSSTSEETVLR_
TRIM24 Phosphorylation S771 3.067 _SILTSLLLNSSQSS(ph)TSEETVLR_
TRIM24 Phosphorylation S808 0.469 _SEWLDPS(ph)QKSPLHVGETR_
TRIM24 Phosphorylation S811 0.564 0.219 _SEWLDPSQKS(ph)PLHVGETR_
TRIM24 Phosphorylation S1042 2.366 1.350 _LKS(ph)IEER_
ZMYM2 Ubiquitylation K104 -1.238 _ITPSSK(gl)ELASQK_
ZMYM2 Phosphorylation S305 0.449 _QPGVDSLS(ph)PVASLPK_
ZMYM2 Ubiquitylation K713 -0.806 _LLYK(gl)QDFAR_
ZMYM2 Phosphorylation S833 -1.534 _MTGS(ph)APPPS(ph)PTPNK_
ZMYM2 Phosphorylation S838 -1.052 -1.038 _MTGS(ph)APPPS(ph)PTPNK_
ZMYM2 Phosphorylation T840 -1.177 _MTGSAPPPSPT(ph)PNK_
ZMYM2 Ubiquitylation K938 -0.141 -1.048 _IPAAIEELK(gl)SK_
ZMYM2 Ubiquitylation K1257 -2.625 _NPLTMENK(gl)ACLR_
ZMYM2 Ubiquitylation K1280 -1.391 _YQVSSLCGTDNEDKITTGK(gl)R_
ZMYM2 Ubiquitylation K1313 -2.209 _MFECYLSK(gl)SPQNLNQR_


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