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Query: CPSF6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CPSF6 0 3.623 -0.660 0.180 1.002 0.250 0.499 0.312 -0.256

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CPSF6 Phosphorylation T407 1.386 1.306 _EMDTART(ph)PLSEAEFEEIMNR_
CPSF6 Phosphorylation T404 1.179 1.083 _EMDT(ph)ARTPLSEAEFEEIMNR_
CPSF6 Ubiquitylation K185 -0.516 -0.824 _TTQSGQMSGEGK(gl)AGPPGGSSR_
CPSF6 Ubiquitylation K79 -0.081 _GAAPNVVYTYTGK(gl)R_
CPSF6 Ubiquitylation K138 0.018 _GFALVGVGSEASSK(gl)K_
CPSF6 Ubiquitylation K139 -0.782 _GFALVGVGSEASSKK(gl)_

Background Information for CPSF6:


Pubmed-CPSF6 »
Uniprot-CPSF6 »
Biogrid-CPSF6 »
ProteomicsDB-CPSF6 »

Tumorportal-CPSF6 »
COSMIC-CPSF6 »
GenomeRNAi-CPSF6 »
Genecards-CPSF6


Protein-protein Interactions for CPSF6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CPSF7 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUDT21 Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS26A Cat. description Hein, Mann, Cell 2015
Category members IP bait CPSF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait JMJD6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WWP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CPSF6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34


Protein complexes (CORUM database) featuring CPSF6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1141 CF IIAm complex (Cleavage factor IIAm complex) Database 2.57
Category members Corum 1769 CPSF6-ITCH-NUDT21-POLR2A complex Database 0.85
Category members Corum 1767 CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex Database 0.43
Category members Corum 1768 CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex Database 0.23


Categories featuring CPSF6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members Pathway Pathway_559 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS 0 1.1
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0051262 protein tetramerization Database 0.6
Category members Pathway Pathway_592 REACTOME_SIGNALING_BY_FGFR1_MUTANTS 0 0.4
Category members Pathway Pathway_528 REACTOME_SIGNALING_BY_FGFR_MUTANTS 0 0.37
Category members GO Category GO:0042382 paraspeckles Database 0.23
Category members GO Category GO:0005849 mRNA cleavage factor complex Database 0.13
Category members GO Category GO:0006378 mRNA polyadenylation Database 0.1


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