bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: STAT5B

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
STAT5B 0 0.270 0.670 -0.960

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
STAT5B Phosphorylation S194 0.270 _IQAQFGPLAQLS(ph)PQER_

Background Information for STAT5B:


Pubmed-STAT5B »
Uniprot-STAT5B »
Biogrid-STAT5B »
ProteomicsDB-STAT5B »

Tumorportal-STAT5B »
COSMIC-STAT5B »
GenomeRNAi-STAT5B »
Genecards-STAT5B


Protein-protein Interactions for STAT5B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait STAT5B Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAM32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C9orf156 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAT5A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in STAT5B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH2 IPR000980 0.05
Category members STAT_TF_prot_interaction IPR013799 0.03
Category members STAT_TF_alpha IPR013800 0.03
Category members STAT_TF_DNA-bd IPR013801 0.03
Category members p53-like_TF_DNA-bd IPR008967 0
Category members STAT_TF_coiled-coil IPR015988 0


Protein complexes (CORUM database) featuring STAT5B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring STAT5B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_559 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS 0 1.1
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0001889 liver development Database 0.51
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members GO Category GO:0051272 positive regulation of cellular component movement Database 0.46
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members GO Category GO:0045647 negative regulation of erythrocyte differentiation Database 0.41
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_592 REACTOME_SIGNALING_BY_FGFR1_MUTANTS 0 0.4
Category members Disease phenotype ACUTE_PROMYELOCYTIC_LEUKEMIA ACUTE PROMYELOCYTIC LEUKEMIA Database 0.39
Category members Pathway Pathway_528 REACTOME_SIGNALING_BY_FGFR_MUTANTS 0 0.37
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members GO Category GO:0040014 regulation of multicellular organism growth Database 0.35
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0001553 luteinization Database 0.31
Category members GO Category GO:0006105 succinate metabolic process Database 0.31
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0048661 positive regulation of smooth muscle cell proliferation Database 0.24
Category members GO Category GO:0030856 regulation of epithelial cell differentiation Database 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members GO Category GO:0045588 positive regulation of gamma-delta T cell differentiation Database 0.22
Category members GO Category GO:0007565 female pregnancy Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members Pathway Pathway_534 BIOCARTA_GLEEVEC_PATHWAY 0 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0006101 citrate metabolic process Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members Pathway Pathway_974 REACTOME_PROLACTIN_RECEPTOR_SIGNALING 0 0.13
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_601 PID_IL2_1PATHWAY 0 0.1
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members Pathway Pathway_578 BIOCARTA_EGF_PATHWAY 0 0.09
Category members Pathway Pathway_584 BIOCARTA_TPO_PATHWAY 0 0.08
Category members GO Category GO:0050729 positive regulation of inflammatory response Database 0.08
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding Database 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members GO Category GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway Database 0.04
Category members Pathway Pathway_434 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 0 0.04
Category members Pathway Pathway_654 PID_IL5_PATHWAY 0 0.04
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members Pathway Pathway_630 BIOCARTA_PDGF_PATHWAY 0 0.03
Category members GO Category GO:0019530 taurine metabolic process Database 0.01
Category members GO Category GO:0032825 positive regulation of natural killer cell differentiation Database 0.01
Category members Pathway Pathway_1077 BIOCARTA_IL2_PATHWAY 0 0
Category members Pathway Pathway_1095 BIOCARTA_IL3_PATHWAY 0 0
Category members Pathway Pathway_1134 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING 0 0
Category members Pathway Pathway_1177 REACTOME_IL_7_SIGNALING 0 0
Category members Pathway Pathway_1181 BIOCARTA_IL22BP_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_419 PID_IL4_2PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_506 REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 0 0
Category members Pathway Pathway_512 REACTOME_IL_2_SIGNALING 0 0
Category members Pathway Pathway_550 PID_IL3_PATHWAY 0 0
Category members Pathway Pathway_567 PID_IL2_STAT5_PATHWAY 0 0
Category members Pathway Pathway_569 PID_GMCSF_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_582 BIOCARTA_IL7_PATHWAY 0 0
Category members Pathway Pathway_591 BIOCARTA_IL2RB_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_609 PID_ERBB4_PATHWAY 0 0
Category members Pathway Pathway_616 BIOCARTA_GH_PATHWAY 0 0
Category members Pathway Pathway_657 PID_FGF_PATHWAY 0 0
Category members Pathway Pathway_700 BIOCARTA_EPO_PATHWAY 0 0
Category members Pathway Pathway_703 PID_EPO_PATHWAY 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members Pathway Pathway_749 BIOCARTA_IL10_PATHWAY 0 0
Category members Pathway Pathway_977 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 0 0
Category members GO Category GO:0000255 allantoin metabolic process Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001779 natural killer cell differentiation Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0006103 2-oxoglutarate metabolic process Database 0
Category members GO Category GO:0006107 oxaloacetate metabolic process Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006549 isoleucine metabolic process Database 0
Category members GO Category GO:0006573 valine metabolic process Database 0
Category members GO Category GO:0006600 creatine metabolic process Database 0
Category members GO Category GO:0006631 fatty acid metabolic process Database 0
Category members GO Category GO:0006953 acute-phase response Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007259 JAK-STAT cascade Database 0
Category members GO Category GO:0007548 sex differentiation Database 0
Category members GO Category GO:0007595 lactation Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0019218 regulation of steroid metabolic process Database 0
Category members GO Category GO:0019915 lipid storage Database 0
Category members GO Category GO:0030155 regulation of cell adhesion Database 0
Category members GO Category GO:0032355 response to estradiol Database 0
Category members GO Category GO:0032819 positive regulation of natural killer cell proliferation Database 0
Category members GO Category GO:0032870 cellular response to hormone stimulus Database 0
Category members GO Category GO:0035259 glucocorticoid receptor binding Database 0
Category members GO Category GO:0038161 prolactin signaling pathway Database 0
Category members GO Category GO:0040018 positive regulation of multicellular organism growth Database 0
Category members GO Category GO:0042104 positive regulation of activated T cell proliferation Database 0
Category members GO Category GO:0042448 progesterone metabolic process Database 0
Category members GO Category GO:0043029 T cell homeostasis Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0045086 positive regulation of interleukin-2 biosynthetic process Database 0
Category members GO Category GO:0045579 positive regulation of B cell differentiation Database 0
Category members GO Category GO:0045621 positive regulation of lymphocyte differentiation Database 0
Category members GO Category GO:0045954 positive regulation of natural killer cell mediated cytotoxicity Database 0
Category members GO Category GO:0046449 creatinine metabolic process Database 0
Category members GO Category GO:0046544 development of secondary male sexual characteristics Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0048541 Peyer's patch development Database 0
Category members GO Category GO:0070669 response to interleukin-2 Database 0
Category members GO Category GO:0070670 response to interleukin-4 Database 0
Category members GO Category GO:0070672 response to interleukin-15 Database 0
Category members GO Category GO:0071363 cellular response to growth factor stimulus Database 0
Category members GO Category GO:0071364 cellular response to epidermal growth factor stimulus Database 0


.

© Copyright Svejstrup Laboratory 2015