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Query: ATF2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ATF2 2 6.813 -1.380 1.800

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ATF2 Phosphorylation S90 2.624 2.389 _NCEEVGLFNELAS(ph)PFENEFKK_
ATF2 Phosphorylation S112 1.025 1.118 _MPLDLS(ph)PLATPIIR_
ATF2 Phosphorylation T71 -1.263 -1.166 _NDSVIVADQTPT(ph)PTR_

Background Information for ATF2:


Pubmed-ATF2 »
Uniprot-ATF2 »
Biogrid-ATF2 »
ProteomicsDB-ATF2 »

Tumorportal-ATF2 »
COSMIC-ATF2 »
GenomeRNAi-ATF2 »
Genecards-ATF2


Protein-protein Interactions for ATF2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait JUN Cat. description Hein, Mann, Cell 2015
Category members IP bait LLGL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARHGAP22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BATF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CREB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOSL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait JUNB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLLT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PFDN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ATF2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2 IPR007087 0.92
Category members bZIP IPR004827 0
Category members TF_cAMP-dep IPR016378 0


Protein complexes (CORUM database) featuring ATF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ATF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0016573 histone acetylation Database 1.24
Category members GO Category GO:0031573 intra-S DNA damage checkpoint Database 1.18
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0035861 site of double-strand break Database 0.65
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0004402 histone acetyltransferase activity Database 0.56
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0001102 RNA polymerase II activating transcription factor binding Database 0.31
Category members GO Category GO:0008140 cAMP response element binding protein binding Database 0.3
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members Pathway Pathway_1001 REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 0 0.2
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members Pathway Pathway_997 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS 0 0.09
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members GO Category GO:0035497 cAMP response element binding Database 0.08
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_996 REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 0 0.05
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0034146 toll-like receptor 5 signaling pathway Database 0.04
Category members GO Category GO:0034166 toll-like receptor 10 signaling pathway Database 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members GO Category GO:0051090 regulation of sequence-specific DNA binding transcription factor activity Database 0.02
Category members GO Category GO:0034134 toll-like receptor 2 signaling pathway Database 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_21 ST_JNK_MAPK_PATHWAY 0 0
Category members Pathway Pathway_422 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_423 PID_IL12_2PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members Pathway Pathway_902 BIOCARTA_41BB_PATHWAY 0 0
Category members Pathway Pathway_998 BIOCARTA_AT1R_PATHWAY 0 0
Category members Pathway Pathway_999 SA_B_CELL_RECEPTOR_COMPLEXES 0 0
Category members GO Category GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding Database 0
Category members GO Category GO:0001076 RNA polymerase II transcription factor binding transcription factor activity Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006970 response to osmotic stress Database 0
Category members GO Category GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway Database 0
Category members GO Category GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway Database 0
Category members GO Category GO:0045444 fat cell differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0051403 stress-activated MAPK cascade Database 0
Category members GO Category GO:0060612 adipose tissue development Database 0


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