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Query: TGFB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TGFB1 0 0.493 -0.550 1.050

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TGFB1 Ubiquitylation K50 -0.557 _GQILSK(gl)LR_

Background Information for TGFB1:


Pubmed-TGFB1 »
Uniprot-TGFB1 »
Biogrid-TGFB1 »
ProteomicsDB-TGFB1 »

Tumorportal-TGFB1 »
COSMIC-TGFB1 »
GenomeRNAi-TGFB1 »
Genecards-TGFB1


Protein-protein Interactions for TGFB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DEFA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLA2G10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TGFB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TGFB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cystine-knot_cytokine IPR029034 0.52
Category members TGF-b_C IPR001839 0.35
Category members TGF-b_N IPR001111 0.17
Category members TGF-beta IPR016319 0


Protein complexes (CORUM database) featuring TGFB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2342 ITGAV-ITGB8-MMP14-TGFB1 complex Database 0
Category members Corum 3026 TGF-beta receptor II-TGF-beta1 complex Database 0
Category members Corum 3027 TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex Database 0
Category members Corum 3042 TGF-beta-receptor II-TGF-beta1 complex Database 0


Categories featuring TGFB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0019058 viral life cycle Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0008083 growth factor activity Database 2.34
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0045786 negative regulation of cell cycle Database 0.93
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members Pathway Pathway_792 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION 0 0.75
Category members GO Category GO:0031334 positive regulation of protein complex assembly Database 0.69
Category members Pathway Pathway_995 PID_ALK1_PATHWAY 0 0.69
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0005796 Golgi lumen Database 0.64
Category members GO Category GO:0030334 regulation of cell migration Database 0.61
Category members GO Category GO:0005578 proteinaceous extracellular matrix Database 0.53
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0050679 positive regulation of epithelial cell proliferation Database 0.5
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members GO Category GO:0000060 protein import into nucleus, translocation Database 0.42
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0048535 lymph node development Database 0.32
Category members Pathway Pathway_1132 KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 0 0.3
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0032930 positive regulation of superoxide anion generation Database 0.27
Category members GO Category GO:0007093 mitotic cell cycle checkpoint Database 0.27
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_816 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 0 0.23
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation Database 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0008354 germ cell migration Database 0.21
Category members GO Category GO:0031065 positive regulation of histone deacetylation Database 0.21
Category members Pathway Pathway_710 PID_UPA_UPAR_PATHWAY 0 0.2
Category members GO Category GO:0050680 negative regulation of epithelial cell proliferation Database 0.19
Category members GO Category GO:0007565 female pregnancy Database 0.19
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0042552 myelination Database 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members GO Category GO:0002062 chondrocyte differentiation Database 0.13
Category members GO Category GO:0045599 negative regulation of fat cell differentiation Database 0.13
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0005902 microvillus Database 0.13
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members GO Category GO:0010718 positive regulation of epithelial to mesenchymal transition Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0070306 lens fiber cell differentiation Database 0.13
Category members GO Category GO:0071158 positive regulation of cell cycle arrest Database 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0030141 secretory granule Database 0.11
Category members GO Category GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity Database 0.1
Category members GO Category GO:0045216 cell-cell junction organization Database 0.1
Category members GO Category GO:0032570 response to progesterone Database 0.1
Category members GO Category GO:0043536 positive regulation of blood vessel endothelial cell migration Database 0.09
Category members Pathway Pathway_1022 PID_SYNDECAN_2_PATHWAY 0 0.08
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0007184 SMAD protein import into nucleus Database 0.08
Category members GO Category GO:0006796 phosphate-containing compound metabolic process Database 0.07
Category members GO Category GO:0009314 response to radiation Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0007492 endoderm development Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Disease phenotype CYSTIC_FIBROSIS CYSTIC FIBROSIS Database 0.04
Category members GO Category GO:0001933 negative regulation of protein phosphorylation Database 0.04
Category members Pathway Pathway_1128 BIOCARTA_TGFB_PATHWAY 0 0.04
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members GO Category GO:0008156 negative regulation of DNA replication Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0042110 T cell activation Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members GO Category GO:0045930 negative regulation of mitotic cell cycle Database 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1054 BIOCARTA_IL1R_PATHWAY 0 0
Category members Pathway Pathway_1124 BIOCARTA_ERYTH_PATHWAY 0 0
Category members Pathway Pathway_1127 SA_MMP_CYTOKINE_CONNECTION 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_424 KEGG_LEISHMANIA_INFECTION 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_476 PID_SYNDECAN_1_PATHWAY 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_637 BIOCARTA_CTCF_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_718 PID_GLYPICAN_1PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_755 PID_RXR_VDR_PATHWAY 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members Pathway Pathway_895 BIOCARTA_INFLAM_PATHWAY 0 0
Category members Pathway Pathway_899 BIOCARTA_NKT_PATHWAY 0 0
Category members Pathway Pathway_903 BIOCARTA_TOB1_PATHWAY 0 0
Category members Pathway Pathway_904 PID_IL12_STAT4_PATHWAY 0 0
Category members Pathway Pathway_909 PID_IL27_PATHWAY 0 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001763 morphogenesis of a branching structure Database 0
Category members GO Category GO:0001775 cell activation Database 0
Category members GO Category GO:0001837 epithelial to mesenchymal transition Database 0
Category members GO Category GO:0002028 regulation of sodium ion transport Database 0
Category members GO Category GO:0002244 hematopoietic progenitor cell differentiation Database 0
Category members GO Category GO:0002248 connective tissue replacement involved in inflammatory response wound healing Database 0
Category members GO Category GO:0002513 tolerance induction to self antigen Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0005114 type II transforming growth factor beta receptor binding Database 0
Category members GO Category GO:0006611 protein export from nucleus Database 0
Category members GO Category GO:0006754 ATP biosynthetic process Database 0
Category members GO Category GO:0006874 cellular calcium ion homeostasis Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007182 common-partner SMAD protein phosphorylation Database 0
Category members GO Category GO:0007183 SMAD protein complex assembly Database 0
Category members GO Category GO:0007406 negative regulation of neuroblast proliferation Database 0
Category members GO Category GO:0007435 salivary gland morphogenesis Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009611 response to wounding Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0010575 positive regulation vascular endothelial growth factor production Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010742 macrophage derived foam cell differentiation Database 0
Category members GO Category GO:0010763 positive regulation of fibroblast migration Database 0
Category members GO Category GO:0010800 positive regulation of peptidyl-threonine phosphorylation Database 0
Category members GO Category GO:0010936 negative regulation of macrophage cytokine production Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0016049 cell growth Database 0
Category members GO Category GO:0016202 regulation of striated muscle tissue development Database 0
Category members GO Category GO:0017015 regulation of transforming growth factor beta receptor signaling pathway Database 0
Category members GO Category GO:0019049 evasion or tolerance of host defenses by virus Database 0
Category members GO Category GO:0022408 negative regulation of cell-cell adhesion Database 0
Category members GO Category GO:0030214 hyaluronan catabolic process Database 0
Category members GO Category GO:0030217 T cell differentiation Database 0
Category members GO Category GO:0030279 negative regulation of ossification Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0030501 positive regulation of bone mineralization Database 0
Category members GO Category GO:0030879 mammary gland development Database 0
Category members GO Category GO:0031093 platelet alpha granule lumen Database 0
Category members GO Category GO:0031536 positive regulation of exit from mitosis Database 0
Category members GO Category GO:0031663 lipopolysaccharide-mediated signaling pathway Database 0
Category members GO Category GO:0032270 positive regulation of cellular protein metabolic process Database 0
Category members GO Category GO:0032355 response to estradiol Database 0
Category members GO Category GO:0032740 positive regulation of interleukin-17 production Database 0
Category members GO Category GO:0032801 receptor catabolic process Database 0
Category members GO Category GO:0032943 mononuclear cell proliferation Database 0
Category members GO Category GO:0032967 positive regulation of collagen biosynthetic process Database 0
Category members GO Category GO:0033280 response to vitamin D Database 0
Category members GO Category GO:0034616 response to laminar fluid shear stress Database 0
Category members GO Category GO:0035066 positive regulation of histone acetylation Database 0
Category members GO Category GO:0035307 positive regulation of protein dephosphorylation Database 0
Category members GO Category GO:0040007 growth Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0042130 negative regulation of T cell proliferation Database 0
Category members GO Category GO:0042307 positive regulation of protein import into nucleus Database 0
Category members GO Category GO:0042482 positive regulation of odontogenesis Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043011 myeloid dendritic cell differentiation Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043029 T cell homeostasis Database 0
Category members GO Category GO:0043406 positive regulation of MAP kinase activity Database 0
Category members GO Category GO:0043491 protein kinase B signaling Database 0
Category members GO Category GO:0043537 negative regulation of blood vessel endothelial cell migration Database 0
Category members GO Category GO:0043932 ossification involved in bone remodeling Database 0
Category members GO Category GO:0045066 regulatory T cell differentiation Database 0
Category members GO Category GO:0045662 negative regulation of myoblast differentiation Database 0
Category members GO Category GO:0046732 active induction of host immune response by virus Database 0
Category members GO Category GO:0048298 positive regulation of isotype switching to IgA isotypes Database 0
Category members GO Category GO:0048565 digestive tract development Database 0
Category members GO Category GO:0048642 negative regulation of skeletal muscle tissue development Database 0
Category members GO Category GO:0048839 inner ear development Database 0
Category members GO Category GO:0050714 positive regulation of protein secretion Database 0
Category members GO Category GO:0050765 negative regulation of phagocytosis Database 0
Category members GO Category GO:0050777 negative regulation of immune response Database 0
Category members GO Category GO:0050868 negative regulation of T cell activation Database 0
Category members GO Category GO:0050921 positive regulation of chemotaxis Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0051098 regulation of binding Database 0
Category members GO Category GO:0051101 regulation of DNA binding Database 0
Category members GO Category GO:0051152 positive regulation of smooth muscle cell differentiation Database 0
Category members GO Category GO:0051280 negative regulation of release of sequestered calcium ion into cytosol Database 0
Category members GO Category GO:0051781 positive regulation of cell division Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0
Category members GO Category GO:0060325 face morphogenesis Database 0
Category members GO Category GO:0060364 frontal suture morphogenesis Database 0
Category members GO Category GO:0060389 pathway-restricted SMAD protein phosphorylation Database 0
Category members GO Category GO:0060391 positive regulation of SMAD protein import into nucleus Database 0
Category members GO Category GO:0060744 mammary gland branching involved in thelarche Database 0
Category members GO Category GO:0060762 regulation of branching involved in mammary gland duct morphogenesis Database 0
Category members GO Category GO:0061035 regulation of cartilage development Database 0
Category members GO Category GO:0070723 response to cholesterol Database 0
Category members GO Category GO:0071363 cellular response to growth factor stimulus Database 0
Category members GO Category GO:0071407 cellular response to organic cyclic compound Database 0


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