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Query: RAPGEF2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAPGEF2 0 1.033 -0.860 1.560

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAPGEF2 Phosphorylation S1022 0.043 -0.570 _SETS(ph)PVAPR_
RAPGEF2 Phosphorylation S1080 -0.612 _DLPPFGINS(ph)PQALK_

Background Information for RAPGEF2:


Pubmed-RAPGEF2 »
Uniprot-RAPGEF2 »
Biogrid-RAPGEF2 »
ProteomicsDB-RAPGEF2 »

Tumorportal-RAPGEF2 »
COSMIC-RAPGEF2 »
GenomeRNAi-RAPGEF2 »
Genecards-RAPGEF2


Protein-protein Interactions for RAPGEF2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC132 Cat. description Hein, Mann, Cell 2015
Category members IP bait MSN Cat. description Hein, Mann, Cell 2015
Category members IP bait RACGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAPGEF2 Cat. description Hein, Mann, Cell 2015


Protein Domains in RAPGEF2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members PDZ IPR001478 0.15
Category members Ras-assoc IPR000159 0
Category members cNMP-bd_dom IPR000595 0
Category members Ras-like_Gua-exchang_fac_N IPR000651 0
Category members RASGEF_cat_dom IPR001895 0
Category members cNMP-bd-like IPR018490 0
Category members Ras_GEF_dom IPR023578 0


Protein complexes (CORUM database) featuring RAPGEF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring RAPGEF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0007218 neuropeptide signaling pathway Database 0.45
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0050699 WW domain binding Database 0.36
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0030165 PDZ domain binding Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0032320 positive regulation of Ras GTPase activity Database 0.26
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members GO Category GO:0048167 regulation of synaptic plasticity Database 0.14
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0005770 late endosome Database 0.09
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0061028 establishment of endothelial barrier Database 0.06
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0045860 positive regulation of protein kinase activity Database 0.06
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0005088 Ras guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0017034 Rap guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0019933 cAMP-mediated signaling Database 0
Category members GO Category GO:0019992 diacylglycerol binding Database 0
Category members GO Category GO:0021591 ventricular system development Database 0
Category members GO Category GO:0021884 forebrain neuron development Database 0
Category members GO Category GO:0030552 cAMP binding Database 0
Category members GO Category GO:0031547 brain-derived neurotrophic factor receptor signaling pathway Database 0
Category members GO Category GO:0031697 beta-1 adrenergic receptor binding Database 0
Category members GO Category GO:0032092 positive regulation of protein binding Database 0
Category members GO Category GO:0032486 Rap protein signal transduction Database 0
Category members GO Category GO:0032854 positive regulation of Rap GTPase activity Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0038180 nerve growth factor signaling pathway Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043950 positive regulation of cAMP-mediated signaling Database 0
Category members GO Category GO:0046582 Rap GTPase activator activity Database 0
Category members GO Category GO:0050774 negative regulation of dendrite morphogenesis Database 0
Category members GO Category GO:0071320 cellular response to cAMP Database 0
Category members GO Category GO:0071321 cellular response to cGMP Database 0


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