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Query: HSPB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSPB1 0 -16.424 0.710 -0.660 -0.632

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSPB1 Phosphorylation S82 1.036 0.723 _QLS(ph)SGVSEIR_
HSPB1 Ubiquitylation K198 -1.654 _AQLGGPEAAK(gl)SDETAAK_

Background Information for HSPB1:


Pubmed-HSPB1 »
Uniprot-HSPB1 »
Biogrid-HSPB1 »
ProteomicsDB-HSPB1 »

Tumorportal-HSPB1 »
COSMIC-HSPB1 »
GenomeRNAi-HSPB1 »
Genecards-HSPB1


Protein-protein Interactions for HSPB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG3 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015
Category members IP bait CRYAB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPB6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSPB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HSP20-like_chaperone IPR008978 0.18
Category members Alpha-crystallin/HSP IPR001436 0
Category members a-crystallin/Hsp20_dom IPR002068 0


Protein complexes (CORUM database) featuring HSPB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HSPB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0000502 proteasome complex Database 3.17
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members Pathway Pathway_776 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 0 1.45
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0006986 response to unfolded protein Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_444 PID_P38_MK2_PATHWAY 0 0.42
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_54 BIOCARTA_MTA3_PATHWAY 0 0.36
Category members Pathway Pathway_983 ST_P38_MAPK_PATHWAY 0 0.34
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members GO Category GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling Database 0.17
Category members GO Category GO:0008426 protein kinase C inhibitor activity Database 0.15
Category members GO Category GO:0043536 positive regulation of blood vessel endothelial cell migration Database 0.09
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0032731 positive regulation of interleukin-1 beta production Database 0.08
Category members GO Category GO:0035924 cellular response to vascular endothelial growth factor stimulus Database 0.06
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04
Category members GO Category GO:0043292 contractile fiber Database 0.04
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members Pathway Pathway_1017 BIOCARTA_HSP27_PATHWAY 0 0
Category members Pathway Pathway_422 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_436 KEGG_VEGF_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members Disease phenotype Distal_hereditary_motor_neuropathy_type_2 Distal hereditary motor neuropathy type 2 Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0042535 positive regulation of tumor necrosis factor biosynthetic process Database 0


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