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Query: TGFBR1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TGFBR1 0 1.003 -0.260 0.020

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TGFBR1 Ubiquitylation K502 0.553 0.430 _TLSQLSQQEGIK(gl)M_
TGFBR1 Ubiquitylation K449 -0.991 _VVCEQK(gl)LRPNIPNR_

Background Information for TGFBR1:


Pubmed-TGFBR1 »
Uniprot-TGFBR1 »
Biogrid-TGFBR1 »
ProteomicsDB-TGFBR1 »

Tumorportal-TGFBR1 »
COSMIC-TGFBR1 »
GenomeRNAi-TGFBR1 »
Genecards-TGFBR1


Protein-protein Interactions for TGFBR1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EPHA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait NLGN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TGFBR1 Cat. description Hein, Mann, Cell 2015


Protein Domains in TGFBR1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Activin_rcpt IPR000472 0
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Quinolinate_PRibosylTrfase_C IPR002638 0
Category members TGF_beta_rcpt_GS IPR003605 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring TGFBR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1779 TGF-beta-receptor-PAR6 complex Database 0
Category members Corum 1828 TGF-beta receptor I-Axin-SMAD3 complex Database 0
Category members Corum 3027 TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex Database 0
Category members Corum 3028 TGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex Database 0
Category members Corum 5735 TGF-beta receptor-SMAD3 complex Database 0


Categories featuring TGFBR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members Pathway Pathway_792 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION 0 0.75
Category members Pathway Pathway_995 PID_ALK1_PATHWAY 0 0.69
Category members GO Category GO:0005923 tight junction Database 0.69
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0051272 positive regulation of cellular component movement Database 0.46
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_816 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 0 0.23
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation Database 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members GO Category GO:0008354 germ cell migration Database 0.21
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0000186 activation of MAPKK activity Database 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members GO Category GO:0009952 anterior/posterior pattern specification Database 0.06
Category members GO Category GO:0043393 regulation of protein binding Database 0.04
Category members GO Category GO:0043235 receptor complex Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_1128 BIOCARTA_TGFB_PATHWAY 0 0.04
Category members GO Category GO:0048663 neuron fate commitment Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0018107 peptidyl-threonine phosphorylation Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0030199 collagen fibril organization Database 0.01
Category members GO Category GO:0048701 embryonic cranial skeleton morphogenesis Database 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1044 BIOCARTA_NTHI_PATHWAY 0 0
Category members Pathway Pathway_1160 PID_INTEGRIN5_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_637 BIOCARTA_CTCF_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_718 PID_GLYPICAN_1PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members Pathway Pathway_903 BIOCARTA_TOB1_PATHWAY 0 0
Category members Disease phenotype Familial_thoracic_aortic_aneurysm_and_aortic_dissection Familial thoracic aortic aneurysm and aortic dissection Database 0
Category members Disease phenotype Loeys-Dietz_syndrome Loeys-Dietz syndrome Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0001824 blastocyst development Database 0
Category members GO Category GO:0001837 epithelial to mesenchymal transition Database 0
Category members GO Category GO:0001937 negative regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0002088 lens development in camera-type eye Database 0
Category members GO Category GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity Database 0
Category members GO Category GO:0004675 transmembrane receptor protein serine/threonine kinase activity Database 0
Category members GO Category GO:0005024 transforming growth factor beta-activated receptor activity Database 0
Category members GO Category GO:0005025 transforming growth factor beta receptor activity, type I Database 0
Category members GO Category GO:0005114 type II transforming growth factor beta receptor binding Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009435 NAD biosynthetic process Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0019838 growth factor binding Database 0
Category members GO Category GO:0030307 positive regulation of cell growth Database 0
Category members GO Category GO:0031396 regulation of protein ubiquitination Database 0
Category members GO Category GO:0032331 negative regulation of chondrocyte differentiation Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0043542 endothelial cell migration Database 0
Category members GO Category GO:0046332 SMAD binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048538 thymus development Database 0
Category members GO Category GO:0048705 skeletal system morphogenesis Database 0
Category members GO Category GO:0048762 mesenchymal cell differentiation Database 0
Category members GO Category GO:0048844 artery morphogenesis Database 0
Category members GO Category GO:0048870 cell motility Database 0
Category members GO Category GO:0050431 transforming growth factor beta binding Database 0
Category members GO Category GO:0051491 positive regulation of filopodium assembly Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0
Category members GO Category GO:0060017 parathyroid gland development Database 0
Category members GO Category GO:0060037 pharyngeal system development Database 0
Category members GO Category GO:0060389 pathway-restricted SMAD protein phosphorylation Database 0
Category members GO Category GO:0060391 positive regulation of SMAD protein import into nucleus Database 0
Category members GO Category GO:0070022 transforming growth factor beta receptor homodimeric complex Database 0
Category members GO Category GO:0070411 I-SMAD binding Database 0
Category members GO Category GO:0070723 response to cholesterol Database 0


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