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Query: TRAF2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TRAF2 1 0.868 -0.570 0.540

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TRAF2 Ubiquitylation K27 -0.253 2.194 _TLLGTK(gl)LEAK_
TRAF2 Ubiquitylation K176 -1.233 1.022 _APCCGADVK(gl)AHHEVCPK_
TRAF2 Ubiquitylation K207 0.147 0.918 _FQDHVK(gl)TCGK_
TRAF2 Ubiquitylation K119 0.519 _GTLK(gl)EYESCHEGR_
TRAF2 Ubiquitylation K481 0.478 _MEAK(gl)DSYVRDDAIFIK_
TRAF2 Ubiquitylation K481 -0.507 0.417 _MEAK(gl)NSYVR_
TRAF2 Phosphorylation T7 -0.822 -1.190 _(ac)AAASVT(ph)PPGSLELLQPGFSK_

Background Information for TRAF2:


Pubmed-TRAF2 »
Uniprot-TRAF2 »
Biogrid-TRAF2 »
ProteomicsDB-TRAF2 »

Tumorportal-TRAF2 »
COSMIC-TRAF2 »
GenomeRNAi-TRAF2 »
Genecards-TRAF2


Protein-protein Interactions for TRAF2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ADAMTS4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DIABLO Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAJB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EDA2R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR107 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LTBR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RABGEF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM9B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDYHV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WNT3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFAND6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TRAF2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TNF_rcpt--assoc_TRAF IPR012227 0.05
Category members Znf_TRAF IPR001293 0
Category members Znf_RING IPR001841 0
Category members MATH IPR002083 0
Category members TRAF-like IPR008974 0
Category members Znf_C3HC4_RING-type IPR018957 0


Protein complexes (CORUM database) featuring TRAF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5212 Kinase maturation complex 2 Database 0.18
Category members Corum 2744 TRAF2-MALT1 complex Database 0
Category members Corum 5210 TANK-TRAF2-TRAF3 complex Database 0
Category members Corum 5529 TRAF2-cIAP1/BIRC2 complex Database 0
Category members Corum 5531 Tumor necrosis factor receptor 1 signaling complex Database 0
Category members Corum 5540 TRAF2-TRADD complex Database 0
Category members Corum 5541 Ternary complex (TRAF2, FADD, TRADD) Database 0


Categories featuring TRAF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_608 SIG_CD40PATHWAYMAP 0 0.89
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0043623 cellular protein complex assembly Database 0.45
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members GO Category GO:0030163 protein catabolic process Database 0.38
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0046328 regulation of JNK cascade Database 0.22
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0051865 protein autoubiquitination Database 0.18
Category members Pathway Pathway_596 PID_TRAIL_PATHWAY 0 0.17
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members GO Category GO:0007250 activation of NF-kappaB-inducing kinase activity Database 0.17
Category members Pathway Pathway_1082 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0.16
Category members GO Category GO:0070207 protein homotrimerization Database 0.16
Category members Pathway Pathway_1015 PID_HIV_NEF_PATHWAY 0 0.15
Category members GO Category GO:0051023 regulation of immunoglobulin secretion Database 0.13
Category members GO Category GO:0050870 positive regulation of T cell activation Database 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0005164 tumor necrosis factor receptor binding Database 0.08
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members GO Category GO:0032743 positive regulation of interleukin-2 production Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0002726 positive regulation of T cell cytokine production Database 0.05
Category members Pathway Pathway_1162 BIOCARTA_SODD_PATHWAY 0 0.04
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members GO Category GO:0034351 negative regulation of glial cell apoptotic process Database 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1020 BIOCARTA_DEATH_PATHWAY 0 0
Category members Pathway Pathway_1021 ST_TUMOR_NECROSIS_FACTOR_PATHWAY 0 0
Category members Pathway Pathway_1045 BIOCARTA_TNFR2_PATHWAY 0 0
Category members Pathway Pathway_1046 BIOCARTA_STRESS_PATHWAY 0 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1049 BIOCARTA_TALL1_PATHWAY 0 0
Category members Pathway Pathway_1098 PID_P38_MKK3_6PATHWAY 0 0
Category members Pathway Pathway_1165 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_483 KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_737 BIOCARTA_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_902 BIOCARTA_41BB_PATHWAY 0 0
Category members Pathway Pathway_954 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION 0 0
Category members Pathway Pathway_986 PID_CD40_PATHWAY 0 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005174 CD40 receptor binding Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0009898 cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0031435 mitogen-activated protein kinase kinase kinase binding Database 0
Category members GO Category GO:0031996 thioesterase binding Database 0
Category members GO Category GO:0033209 tumor necrosis factor-mediated signaling pathway Database 0
Category members GO Category GO:0035631 CD40 receptor complex Database 0
Category members GO Category GO:0043507 positive regulation of JUN kinase activity Database 0
Category members GO Category GO:0046625 sphingolipid binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0
Category members GO Category GO:0070534 protein K63-linked ubiquitination Database 0


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