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Query: DAXX

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DAXX 0 2.196 0.430 -1.030
DAXX 0 2.196 0.430 -1.030 -0.712 0.311

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DAXX Phosphorylation S495 0.727 0.865 _DGDKS(ph)PMSSLQISNEK_
DAXX Ubiquitylation K255 1.051 -0.046 _LCELK(gl)DCSSLTGR_
DAXX Phosphorylation S702 -0.432 -0.620 _VDSPSHGLVTSSLCIPS(ph)PAR_
DAXX Phosphorylation S688 -0.111 -0.664 _VDS(ph)PSHGLVTSSLCIPSPAR_
DAXX Phosphorylation S671 -0.877 -1.038 _ICTLPSPPS(ph)PLASLAPVADSSTR_
DAXX Phosphorylation S178 -1.839 -1.808 _KLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQS(ph)PR_
DAXX Phosphorylation S33 -2.344 -2.634 _(ac)ATANSIIVLDDDDEDEAAAQPGPSHPLPNAAS(ph)PGAEAPSSSEPHGAR_
DAXX Phosphorylation S675 -0.654 _KICTLPSPPSPLAS(ph)LAPVADSSTR_
DAXX Phosphorylation S690 -0.048 _VDS(ph)PSHGLVTSSLCIPSPAR_
DAXX Ubiquitylation K289 -0.127 _LINK(gl)PGPDTFPDYGDVLR_
DAXX Ubiquitylation K390 0.502 _LDEVISK(gl)YAMLQDK_

Background Information for DAXX:


Pubmed-DAXX »
Uniprot-DAXX »
Biogrid-DAXX »
ProteomicsDB-DAXX »

Tumorportal-DAXX »
COSMIC-DAXX »
GenomeRNAi-DAXX »
Genecards-DAXX


Protein-protein Interactions for DAXX
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATRX Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DAXX Cat. description Hein, Mann, Cell 2015
Category members IP bait ARHGAP22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CASQ2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPIN2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DAXX
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring DAXX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2839 ATRX-DAXX complex Database 0.25
Category members Corum 2843 ATRX-DAXX complex Database 0.25
Category members Corum 1243 Ubiquitin E3 ligase (SPOP, DAXX, CUL3) Database 0.04
Category members Corum 1490 DAXX-DNMT1-DMAP1 complex Database 0.04
Category members Corum 2842 DAXX-Axin-p53-HIPK2 complex Database 0
Category members Corum 3170 Daxx-Axin-p53 complex Database 0


Categories featuring DAXX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0000792 heterochromatin Database 5.45
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members GO Category GO:0031072 heat shock protein binding Database 1.59
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0000281 mitotic cytokinesis Database 0.77
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_1015 PID_HIV_NEF_PATHWAY 0 0.15
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members GO Category GO:0007257 activation of JUN kinase activity Database 0.08
Category members Pathway Pathway_1062 BIOCARTA_PML_PATHWAY 0 0.06
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1017 BIOCARTA_HSP27_PATHWAY 0 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members GO Category GO:0005057 receptor signaling protein activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors Database 0
Category members GO Category GO:0031396 regulation of protein ubiquitination Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


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