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Query: MEF2C

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MEF2C 0 2.020 -0.980 1.550

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MEF2C Phosphorylation S406 0.272 0.338 _SEPVS(ph)PPRDR_
MEF2C Phosphorylation S240 0.008 0.302 _NS(ph)PGLLVSPGNLNK_
MEF2C Ubiquitylation K23 -0.140 _QVTFTK(gl)R_

Background Information for MEF2C:


Pubmed-MEF2C »
Uniprot-MEF2C »
Biogrid-MEF2C »
ProteomicsDB-MEF2C »

Tumorportal-MEF2C »
COSMIC-MEF2C »
GenomeRNAi-MEF2C »
Genecards-MEF2C


Protein-protein Interactions for MEF2C
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MEF2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MEF2C
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TF_MADSbox IPR002100 0
Category members HJURP_C IPR022102 0


Protein complexes (CORUM database) featuring MEF2C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MEF2C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0010694 positive regulation of alkaline phosphatase activity Database 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0030224 monocyte differentiation Database 0.45
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0055005 ventricular cardiac myofibril assembly Database 0.32
Category members Pathway Pathway_1143 PID_HDAC_CLASSII_PATHWAY 0 0.3
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0061337 cardiac conduction Database 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members GO Category GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding Database 0.21
Category members Pathway Pathway_1001 REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 0 0.2
Category members GO Category GO:0050680 negative regulation of epithelial cell proliferation Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0060297 regulation of sarcomere organization Database 0.17
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members GO Category GO:0002062 chondrocyte differentiation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members GO Category GO:0035690 cellular response to drug Database 0.1
Category members GO Category GO:0042692 muscle cell differentiation Database 0.1
Category members GO Category GO:0060045 positive regulation of cardiac muscle cell proliferation Database 0.09
Category members GO Category GO:0002634 regulation of germinal center formation Database 0.08
Category members GO Category GO:0001947 heart looping Database 0.08
Category members GO Category GO:0042100 B cell proliferation Database 0.08
Category members GO Category GO:0030017 sarcomere Database 0.06
Category members GO Category GO:0021542 dentate gyrus development Database 0.06
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_996 REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 0 0.05
Category members GO Category GO:0001958 endochondral ossification Database 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0010613 positive regulation of cardiac muscle hypertrophy Database 0.04
Category members GO Category GO:0034146 toll-like receptor 5 signaling pathway Database 0.04
Category members GO Category GO:0034166 toll-like receptor 10 signaling pathway Database 0.04
Category members GO Category GO:0051149 positive regulation of muscle cell differentiation Database 0.04
Category members GO Category GO:0003138 primary heart field specification Database 0.04
Category members GO Category GO:0003185 sinoatrial valve morphogenesis Database 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members GO Category GO:0035984 cellular response to trichostatin A Database 0.04
Category members GO Category GO:0060025 regulation of synaptic activity Database 0.04
Category members GO Category GO:0048703 embryonic viscerocranium morphogenesis Database 0.02
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0001782 B cell homeostasis Database 0.02
Category members GO Category GO:0034134 toll-like receptor 2 signaling pathway Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0048704 embryonic skeletal system morphogenesis Database 0
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1006 PID_MAPK_TRK_PATHWAY 0 0
Category members Pathway Pathway_1038 REACTOME_MYOGENESIS 0 0
Category members Pathway Pathway_1063 REACTOME_ERK_MAPK_TARGETS 0 0
Category members Pathway Pathway_1065 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION 0 0
Category members Pathway Pathway_365 BIOCARTA_CARM_ER_PATHWAY 0 0
Category members Pathway Pathway_422 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_570 BIOCARTA_ERK5_PATHWAY 0 0
Category members Pathway Pathway_574 BIOCARTA_HDAC_PATHWAY 0 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members Pathway Pathway_938 BIOCARTA_PGC1A_PATHWAY 0 0
Category members Pathway Pathway_998 BIOCARTA_AT1R_PATHWAY 0 0
Category members GO Category GO:0000002 mitochondrial genome maintenance Database 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity Database 0
Category members GO Category GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0000987 core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0001046 core promoter sequence-specific DNA binding Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0001974 blood vessel remodeling Database 0
Category members GO Category GO:0002467 germinal center formation Database 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0003139 secondary heart field specification Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0003211 cardiac ventricle formation Database 0
Category members GO Category GO:0003680 AT DNA binding Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006959 humoral immune response Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007517 muscle organ development Database 0
Category members GO Category GO:0007519 skeletal muscle tissue development Database 0
Category members GO Category GO:0007521 muscle cell fate determination Database 0
Category members GO Category GO:0007611 learning or memory Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0014033 neural crest cell differentiation Database 0
Category members GO Category GO:0014898 cardiac muscle hypertrophy in response to stress Database 0
Category members GO Category GO:0014902 myotube differentiation Database 0
Category members GO Category GO:0030182 neuron differentiation Database 0
Category members GO Category GO:0030220 platelet formation Database 0
Category members GO Category GO:0030279 negative regulation of ossification Database 0
Category members GO Category GO:0030318 melanocyte differentiation Database 0
Category members GO Category GO:0030501 positive regulation of bone mineralization Database 0
Category members GO Category GO:0030890 positive regulation of B cell proliferation Database 0
Category members GO Category GO:0031667 response to nutrient levels Database 0
Category members GO Category GO:0033197 response to vitamin E Database 0
Category members GO Category GO:0033613 activating transcription factor binding Database 0
Category members GO Category GO:0035051 cardiocyte differentiation Database 0
Category members GO Category GO:0035198 miRNA binding Database 0
Category members GO Category GO:0035914 skeletal muscle cell differentiation Database 0
Category members GO Category GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway Database 0
Category members GO Category GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway Database 0
Category members GO Category GO:0045165 cell fate commitment Database 0
Category members GO Category GO:0045652 regulation of megakaryocyte differentiation Database 0
Category members GO Category GO:0045663 positive regulation of myoblast differentiation Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0045669 positive regulation of osteoblast differentiation Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0048311 mitochondrion distribution Database 0
Category members GO Category GO:0048643 positive regulation of skeletal muscle tissue development Database 0
Category members GO Category GO:0048666 neuron development Database 0
Category members GO Category GO:0050853 B cell receptor signaling pathway Database 0
Category members GO Category GO:0051145 smooth muscle cell differentiation Database 0
Category members GO Category GO:0051403 stress-activated MAPK cascade Database 0
Category members GO Category GO:0055007 cardiac muscle cell differentiation Database 0
Category members GO Category GO:0055012 ventricular cardiac muscle cell differentiation Database 0
Category members GO Category GO:0060536 cartilage morphogenesis Database 0
Category members GO Category GO:0061333 renal tubule morphogenesis Database 0
Category members GO Category GO:0071222 cellular response to lipopolysaccharide Database 0
Category members GO Category GO:0071277 cellular response to calcium ion Database 0
Category members GO Category GO:0071300 cellular response to retinoic acid Database 0
Category members GO Category GO:0071333 cellular response to glucose stimulus Database 0
Category members GO Category GO:0071363 cellular response to growth factor stimulus Database 0
Category members GO Category GO:0071374 cellular response to parathyroid hormone stimulus Database 0
Category members GO Category GO:0071407 cellular response to organic cyclic compound Database 0


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