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Query: ZFYVE9

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ZFYVE9 0 1.899 -0.930 0.760

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ZFYVE9 Ubiquitylation K543 1.139 _GNEATEGSGLLLNSTGDLMK(gl)K_
ZFYVE9 Ubiquitylation K544 1.139 _GNEATEGSGLLLNSTGDLMK(gl)K_
ZFYVE9 Ubiquitylation K622 0.886 _NKNDILGKAK(gl)_

Background Information for ZFYVE9:


Pubmed-ZFYVE9 »
Uniprot-ZFYVE9 »
Biogrid-ZFYVE9 »
ProteomicsDB-ZFYVE9 »

Tumorportal-ZFYVE9 »
COSMIC-ZFYVE9 »
GenomeRNAi-ZFYVE9 »
Genecards-ZFYVE9


Protein-protein Interactions for ZFYVE9
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SMAD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait DEFA6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCKIPSD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMAD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ZFYVE9
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_FYVE_PHD IPR011011 1.23
Category members Znf_FYVE_SARA/endofin IPR017165 0.05
Category members DUF3480 IPR022557 0.05
Category members Znf_FYVE IPR000306 0
Category members Znf_FYVE-rel IPR017455 0


Protein complexes (CORUM database) featuring ZFYVE9
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1827 PML-SMAD2/3-SARA complex Database 0.01


Categories featuring ZFYVE9
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_816 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 0 0.23
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members GO Category GO:0007184 SMAD protein import into nucleus Database 0.08
Category members Pathway Pathway_1128 BIOCARTA_TGFB_PATHWAY 0 0.04
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0005545 1-phosphatidylinositol binding Database 0
Category members GO Category GO:0007183 SMAD protein complex assembly Database 0
Category members GO Category GO:0008236 serine-type peptidase activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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