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Query: EP300

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EP300 0 -0.467 -1.210 1.320 -1.089 -1.694 -0.723

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EP300 Phosphorylation S2328 -1.092 0.725 _PQSQPPHSSPS(ph)PR_
EP300 Phosphorylation S1726 0.994 0.627 _LGLGLDDESNNQQAAATQS(ph)PGDSRR_
EP300 Phosphorylation S1038 -0.672 -0.349 _TEIKEEEDQPSTSATQSS(ph)PAPGQSK_

Background Information for EP300:


Pubmed-EP300 »
Uniprot-EP300 »
Biogrid-EP300 »
ProteomicsDB-EP300 »

Tumorportal-EP300 »
COSMIC-EP300 »
GenomeRNAi-EP300 »
Genecards-EP300


Protein-protein Interactions for EP300
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EP300 Cat. description Hein, Mann, Cell 2015
Category members IP bait C3orf62 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTGF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPATA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EP300
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Bromodomain IPR001487 1.43
Category members Znf_FYVE_PHD IPR011011 1.23
Category members Znf_TAZ IPR000197 0.33
Category members KIX_dom IPR003101 0.33
Category members DUF902_CREBbp IPR010303 0.33
Category members Histone_H3-K56_AcTrfase_RTT109 IPR013178 0.33
Category members Nuc_rcpt_coact_CREBbp IPR014744 0.33
Category members Nuc_rcpt_coact IPR009110 0.16
Category members Znf_ZZ IPR000433 0.01


Protein complexes (CORUM database) featuring EP300
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 570 p300-CBP-p270-SWI/SNF complex Database 0.62
Category members Corum 2639 HES1 promoter-Notch enhancer complex Database 0.45
Category members Corum 4 Multisubunit ACTR coactivator complex Database 0.31
Category members Corum 1158 p33ING1b-p300 complex Database 0.13
Category members Corum 571 p300-CBP-p270 complex Database 0.1
Category members Corum 98 p300-MDM2-p53 protein complex Database 0.1
Category members Corum 1831 PIAS3-SMAD3-P300 complex Database 0.07
Category members Corum 1160 ING1-p300-PCNA complex Database 0
Category members Corum 1471 pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300) Database 0
Category members Corum 2638 HES1 promoter corepressor complex Database 0
Category members Corum 2641 p300/CBP-PCAF-MyoD complex Database 0
Category members Corum 2642 SMAD1-P300 complex Database 0
Category members Corum 5118 pRb2/p130-multimolecular complex (RB2, E2F4, HDAC1, SUV39H1, P300) Database 0
Category members Corum 5260 TCF4-CTNNB1-SUMO1-EP300-HADAC6 complex Database 0
Category members Corum 5261 TCF4-CTNNB1-EP300 complex Database 0
Category members Corum 5375 EGR-EP300 complex Database 0


Categories featuring EP300
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0000785 chromatin Database 2.59
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members GO Category GO:0016573 histone acetylation Database 1.24
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members Pathway Pathway_118 PID_FOXO_PATHWAY 0 0.97
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members GO Category GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Database 0.83
Category members GO Category GO:0010942 positive regulation of cell death Database 0.82
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members Pathway Pathway_748 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION 0 0.66
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0004402 histone acetyltransferase activity Database 0.56
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members Pathway Pathway_753 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN 0 0.35
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members Pathway Pathway_744 PID_HDAC_CLASSIII_PATHWAY 0 0.34
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia Database 0.32
Category members GO Category GO:0001102 RNA polymerase II activating transcription factor binding Database 0.31
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members Pathway Pathway_1176 BIOCARTA_PITX2_PATHWAY 0 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0043923 positive regulation by host of viral transcription Database 0.27
Category members GO Category GO:0051059 NF-kappaB binding Database 0.25
Category members Pathway Pathway_891 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION 0 0.24
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members Pathway Pathway_945 BIOCARTA_VDR_PATHWAY 0 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members GO Category GO:0003712 transcription cofactor activity Database 0.21
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members GO Category GO:0034612 response to tumor necrosis factor Database 0.21
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members GO Category GO:0031324 negative regulation of cellular metabolic process Database 0.18
Category members Pathway Pathway_759 BIOCARTA_P53HYPOXIA_PATHWAY 0 0.18
Category members GO Category GO:0016746 transferase activity, transferring acyl groups Database 0.17
Category members Pathway Pathway_948 BIOCARTA_CARM1_PATHWAY 0 0.17
Category members GO Category GO:0000123 histone acetyltransferase complex Database 0.15
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0003823 antigen binding Database 0.13
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0051019 mitogen-activated protein kinase binding Database 0.13
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members Pathway Pathway_537 PID_IFNG_PATHWAY 0 0.11
Category members GO Category GO:0001047 core promoter binding Database 0.11
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0018076 N-terminal peptidyl-lysine acetylation Database 0.1
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_113 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 0 0.08
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members GO Category GO:0042975 peroxisome proliferator activated receptor binding Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0016407 acetyltransferase activity Database 0.05
Category members Pathway Pathway_1226 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY 0 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0033160 positive regulation of protein import into nucleus, translocation Database 0.04
Category members GO Category GO:0051384 response to glucocorticoid Database 0.04
Category members GO Category GO:0001159 core promoter proximal region DNA binding Database 0.04
Category members Pathway Pathway_1128 BIOCARTA_TGFB_PATHWAY 0 0.04
Category members GO Category GO:0031325 positive regulation of cellular metabolic process Database 0.04
Category members GO Category GO:0065004 protein-DNA complex assembly Database 0.03
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0018393 internal peptidyl-lysine acetylation Database 0.01
Category members Pathway Pathway_639 BIOCARTA_HER2_PATHWAY 0 0.01
Category members Pathway Pathway_1047 BIOCARTA_RELA_PATHWAY 0 0.01
Category members GO Category GO:0070301 cellular response to hydrogen peroxide Database 0
Category members Pathway Pathway_1044 BIOCARTA_NTHI_PATHWAY 0 0
Category members Pathway Pathway_1144 BIOCARTA_MEF2D_PATHWAY 0 0
Category members Pathway Pathway_1165 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION 0 0
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Pathway Pathway_156 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION 0 0
Category members Pathway Pathway_186 PID_HNF3A_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_365 BIOCARTA_CARM_ER_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_407 BIOCARTA_HIF_PATHWAY 0 0
Category members Pathway Pathway_440 PID_FRA_PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_582 BIOCARTA_IL7_PATHWAY 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_940 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA 0 0
Category members Pathway Pathway_946 PID_RETINOIC_ACID_PATHWAY 0 0
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0001085 RNA polymerase II transcription factor binding Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001756 somitogenesis Database 0
Category members GO Category GO:0004468 lysine N-acetyltransferase activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007519 skeletal muscle tissue development Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010560 positive regulation of glycoprotein biosynthetic process Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0030307 positive regulation of cell growth Database 0
Category members GO Category GO:0031490 chromatin DNA binding Database 0
Category members GO Category GO:0032025 response to cobalt ion Database 0
Category members GO Category GO:0032092 positive regulation of protein binding Database 0
Category members GO Category GO:0032526 response to retinoic acid Database 0
Category members GO Category GO:0032967 positive regulation of collagen biosynthetic process Database 0
Category members GO Category GO:0032993 protein-DNA complex Database 0
Category members GO Category GO:0033613 activating transcription factor binding Database 0
Category members GO Category GO:0035259 glucocorticoid receptor binding Database 0
Category members GO Category GO:0043388 positive regulation of DNA binding Database 0
Category members GO Category GO:0043425 bHLH transcription factor binding Database 0
Category members GO Category GO:0043491 protein kinase B signaling Database 0
Category members GO Category GO:0043967 histone H4 acetylation Database 0
Category members GO Category GO:0045727 positive regulation of translation Database 0
Category members GO Category GO:0045773 positive regulation of axon extension Database 0
Category members GO Category GO:0045793 positive regulation of cell size Database 0
Category members GO Category GO:0045862 positive regulation of proteolysis Database 0
Category members GO Category GO:0046332 SMAD binding Database 0
Category members GO Category GO:0048565 digestive tract development Database 0
Category members GO Category GO:0050714 positive regulation of protein secretion Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0
Category members GO Category GO:0060298 positive regulation of sarcomere organization Database 0
Category members GO Category GO:0060765 regulation of androgen receptor signaling pathway Database 0
Category members GO Category GO:0070542 response to fatty acid Database 0
Category members GO Category GO:0071407 cellular response to organic cyclic compound Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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