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REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION
(Pathway_90)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
SMARCD3 2 0.790 -0.310 0.206 1.501 1.642
NFYA 1 2.320 -0.640
ABCB4 1 -0.790 1.130 2.195
MED24 1 -1.120 1.330 -0.351 -0.190 0.792 -0.333
MED17 1 0.700 -0.990 -1.647 1.651 -0.170 -0.346
MED26 1 0.500 -1.120
MED23 1 0.740 -0.420 0.242 1.739 -1.089 0.014
HMGCS1 1 -1.450 3.080 -0.209 0.030
ACADM 1 -0.780 0.040 0.342 1.733 -1.179 1.338 1.228
MED20 1 2.740 -1.100 -0.895
MED1 1 0.780 -0.520 -1.530 -0.219
MED4 1 -1.480 2.730
NCOA2 1 -0.210 -0.230
CPT2 1 -0.880 2.130 -0.156 1.567 1.079
MED8 1 -0.200 -0.330 -3.450
MED30 1 2.100 -1.330
MED16 1 -0.070 -0.120 -0.498 0.991 1.893 -1.924 -1.039
MED14 1 -0.700 0.420 -2.483 0.951 1.842 -1.302 -0.509
CREBBP 0 0.840 -0.950 -3.889 -1.071
TEAD3 0 0.130 -0.570
TEAD3 0 0.130 -0.570
MED29 0 0.440 -0.570
ME1 0
SREBF1 0 0.540 -0.490
SREBF1 0 0.540 -0.490
TEAD2 0 0.050 -0.130
FDFT1 0 -0.960 0.750 -0.161 -0.107 -0.241 -0.023 0.147
NCOA1 0 1.240 -0.460
EP300 0 -1.210 1.320 -1.089 -1.694 -0.723
TBL1X 0 -0.240 -0.140 0.090 -3.400 0.909 0.103 0.241
NRF1 0 -0.381 0.350 0.053
CCNC 0 0.760 -0.860
HMGCR 0 0.240 0.010
APOA1 0 0.850 -0.420 -3.959
NFYB 0 -1.100 1.620 0.915
MED13L 0 -0.540 0.950
NCOA3 0 0.000 -0.330
MED18 0
MED10 0
MED6 0 0.150 -0.220 -2.260
TGS1 0 0.840 -0.360
YAP1 0 1.010 -0.370
MED9 0 -0.470 -0.150
NCOR1 0 -0.820 1.130 -0.827 -0.215 0.037
TIAM2 0 -0.270 0.280
TIAM2 0 -0.190 -0.090
FADS1 0 -0.870 0.300
ACSL1 0 -1.550 2.430 -0.319 0.348 -0.094
ACSL1 0 -1.090 1.870 -0.319 0.348 -0.094
PPARGC1B 0 0.740 -0.460
MED27 0 -0.870 1.300 -3.189
ACOX1 0 0.460 -0.300
MED11 0
HDAC3 0 -0.790 1.070
ESRRA 0 -0.770 0.700 0.047 0.181
TBL1XR1 0 -0.370 0.750 0.090 -3.400 0.909 0.103 0.241
MED12 0 -0.180 -0.500 -1.501 -0.491
TEAD1 0 -0.020 0.420
TEAD1 0 -0.020 0.420
TEAD4 0 0.390 -0.180
TXNRD1 0 -0.400 -0.200
NCOA6 0 -0.430 0.770 -0.167 0.096
SREBF2 0 0.120 -0.140

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ABCB4 Ubiquitylation K271 1.459 _TVIAFGGQK(gl)K_
ABCB4 Ubiquitylation K272 1.009 _TVIAFGGQKK(gl)_
ABCB4 Ubiquitylation K279 -0.087 0.047 _YNK(gl)NLEEAKR_
ABCB4 Ubiquitylation K617 0.890 _GNHDELMK(gl)EK_
ABCB4 Ubiquitylation K826 -0.613 0.002 _LANDAAQVK(gl)GAIGSR_
ABCB4 Ubiquitylation K1093 -1.090 _FYDPLAGK(gl)VLLDGK_
ACOX1 Phosphorylation S26 -0.372 _DSASFNPELLTHILDGS(ph)PEK_
ACOX1 Ubiquitylation K122 -0.820 _EK(gl)WLLSSK_
ACSL1 Ubiquitylation K386 -0.432 _IFGQANTTLK(gl)R_
ACSL1 Ubiquitylation K521 -2.563 _GPNVFQGYLK(gl)DPAK_
CCNC Ubiquitylation K117 0.126 _LIAAATSVLK(gl)TR_
CPT2 Ubiquitylation K189 -0.819 _SDTITFK(gl)R_
CPT2 Ubiquitylation K510 -0.730 _TETIRPASVYTK(gl)R_
CREBBP Phosphorylation S2093 0.037 0.097 _SIS(ph)PSALQDLLR_
EP300 Phosphorylation S1038 -0.672 -0.349 _TEIKEEEDQPSTSATQSS(ph)PAPGQSK_
EP300 Phosphorylation S1726 0.994 0.627 _LGLGLDDESNNQQAAATQS(ph)PGDSRR_
EP300 Phosphorylation S2328 -1.092 0.725 _PQSQPPHSSPS(ph)PR_
FADS1 Ubiquitylation K106 0.142 _NK(gl)ELTDEFR_
FADS1 Ubiquitylation K251 1.457 _ILSVELGK(gl)QK_
FDFT1 Ubiquitylation K41 -0.022 _MDQDSLSSSLK(gl)TCYK_
FDFT1 Ubiquitylation K45 -0.877 -0.339 _TCYK(gl)YLNQTSR_
FDFT1 Ubiquitylation K115 -0.424 _FMESK(gl)EKDR_
FDFT1 Ubiquitylation K213 -0.200 _ANSMGLFLQK(gl)TNIIR_
FDFT1 Ubiquitylation K358 -2.436 -0.946 _IPDSDPSSSK(gl)TR_
HDAC3 Phosphorylation S424 -0.354 _GPEENYSRPEAPNEFYDGDHDNDKES(ph)DVEI_
HMGCR Ubiquitylation K142 -0.522 _ASTLAK(gl)FALSSNSQDEVR_
HMGCR Ubiquitylation K248 -3.854 -2.107 _VLEEEENK(gl)PNPVTQR_
HMGCR Ubiquitylation K299 -1.680 -0.460 _VSLGLDENVSK(gl)R_
HMGCR Ubiquitylation K363 -1.750 _NPITSPVVTQKK(gl)_
HMGCR Ubiquitylation K381 -0.848 _NNQK(gl)CDSVEEETGINR_
HMGCR Ubiquitylation K401 -3.050 _KVEVIK(gl)PLVAETDTPNR_
HMGCR Ubiquitylation K502 -1.382 _K(gl)LSEPSSLQYLPYR_
HMGCR Ubiquitylation K633 -1.104 _LQK(gl)LHTSIAGR_
HMGCR Ubiquitylation K662 -1.291 _SGDAMGMNMISK(gl)GTEK_
HMGCR Ubiquitylation K704 -1.716 _GK(gl)SVVCEAVIPAK(gl)VVR_
HMGCR Ubiquitylation K715 -1.982 _SVVCEAVIPAK(gl)VVR_
HMGCR Ubiquitylation K873 -1.345 _SK(gl)INLQDLQGACTKK_
HMGCR Ubiquitylation K885 -1.690 _SKINLQDLQGACTK(gl)K_
HMGCR Ubiquitylation K886 -1.325 _INLQDLQGACTKK(gl)_
HMGCS1 Phosphorylation S4 -1.161 -1.052 _PGS(ph)LPLNAEACWPK_
HMGCS1 Ubiquitylation K100 -0.673 _LEVGTETIIDK(gl)SK_
HMGCS1 Ubiquitylation K102 -1.761 -0.427 _LEVGTETIIDKSK(gl)_
HMGCS1 Ubiquitylation K273 -0.550 -0.790 _LVQK(gl)SLAR_
HMGCS1 Ubiquitylation K321 -0.588 -0.833 _AFMK(gl)ASSELFSQK_
HMGCS1 Ubiquitylation K330 -0.934 _ASSELFSQK(gl)TK_
HMGCS1 Ubiquitylation K332 -0.326 _ASSELFSQKTK(gl)_
HMGCS1 Ubiquitylation K409 -0.898 _ITASLCDLK(gl)SR_
HMGCS1 Ubiquitylation K428 -1.720 _TGVAPDVFAENMK(gl)LR_
HMGCS1 Phosphorylation S495 -1.763 -1.842 _RPTPNDDTLDEGVGLVHSNIATEHIPS(ph)PAKK_
ME1 Ubiquitylation K422 -0.582 _AECSAEQCYK(gl)ITK_
ME1 Ubiquitylation K512 0.582 -0.154 _DVSLK(gl)IAEK_
ME1 Ubiquitylation K516 0.190 _IAEK(gl)IVK_
ME1 Ubiquitylation K536 -1.965 _TATVYPEPQNK(gl)EAFVR_
MED1 Phosphorylation S664 3.368 _DNPAQDFSTLYGSS(ph)PLER_
MED1 Phosphorylation S771 -1.422 _LSS(ph)SDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLR_
MED1 Phosphorylation T1051 -1.201 -1.247 _SQT(ph)PPGVATPPIPK_
MED1 Phosphorylation T1057 -1.294 _SQT(ph)PPGVAT(ph)PPIPK_
MED1 Phosphorylation S1155 0.689 _NSSQSGGKPGS(ph)SPITK_
MED1 Phosphorylation S1156 0.829 1.055 _NSSQSGGKPGSS(ph)PITK_
MED1 Phosphorylation S1192 -0.792 _PSSLM(ox)NPSLSKPNIS(ph)PSHSRPPGGSDK_
MED1 Phosphorylation S1223 1.061 1.013 _AKS(ph)PISSGSGGSHM(ox)SGTSSSSGM(ox)K_
MED1 Phosphorylation S1433 -0.191 _NYGS(ph)PLISGSTPK_
MED10 Ubiquitylation K4 -1.822 -1.288 _(ac)AEK(gl)FDHLEEHLEK_
MED10 Ubiquitylation K53 -0.830 0.455 _LNFIVTGLQDIDK(gl)CR_
MED10 Ubiquitylation K82 -1.856 -0.301 _NPQLYTK(gl)ECLER_
MED10 Ubiquitylation K91 0.241 _ALAK(gl)NEQVK_
MED10 Ubiquitylation K98 -1.357 _GK(gl)IDTMKK_
MED10 Ubiquitylation K104 -0.971 _GKIDTMKK(gl)_
MED10 Ubiquitylation K106 0.002 _FK(gl)SLLIQELSK_
MED11 Ubiquitylation K103 -0.026 _LK(gl)LSDVAR_
MED12 Ubiquitylation K429 -0.439 _EIEQQIK(gl)ER_
MED12 Ubiquitylation K531 -0.272 _AMVVAKLLEK(gl)_
MED12 Phosphorylation S635 -1.278 -0.801 _GDLAFGAPGPRPPS(ph)PFDDPADDPEHK_
MED12 Ubiquitylation K1001 -1.092 _VK(gl)NTIYCNVEPSESNMR_
MED12 Ubiquitylation K1661 -1.781 _DVITCEPQGSLIDTK(gl)GNK_
MED12 Ubiquitylation K1682 -0.745 _EGLQVSTK(gl)QK_
MED12 Ubiquitylation K1684 -0.960 _EGLQVSTK(gl)QK_
MED13L Phosphorylation S817 -0.258 _AGSSSLTQVTDLAPSLHDLDNIFDNS(ph)DDDELGAVSPALR_
MED13L Phosphorylation S923 0.430 0.314 _MEVEDGLGS(ph)PKPEEIKDFSYVHK_
MED14 Ubiquitylation K176 -0.354 _DK(gl)IIPPDPITK_
MED14 Ubiquitylation K487 0.044 _SVNDDMK(gl)R_
MED14 Ubiquitylation K699 -0.410 _GITEETQK(gl)ALDR_
MED14 Phosphorylation S986 -1.229 -1.699 _SVNEDDNPPS(ph)PIGGDM(ox)MDSLISQLQPPPQQQPFPK_
MED14 Ubiquitylation K1256 -1.340 _VALSPK(gl)TNQTLQLK_
MED16 Ubiquitylation K158 -0.972 _SGASSFGEK(gl)FSR_
MED16 Ubiquitylation K252 -0.659 _VCVSVVSEK(gl)CR_
MED16 Ubiquitylation K796 -1.345 _LHLGACPTEECK(gl)ACTR_
MED16 Ubiquitylation K817 -0.515 _TTAVK(gl)QWEQR_
MED18 Ubiquitylation K103 0.627 _YLGQPEMGDK(gl)NR_
MED20 Ubiquitylation K106 -0.176 _GFFQSAK(gl)ASK_
MED20 Ubiquitylation K202 -0.568 _K(gl)QQQVPVAGIR_
MED23 Ubiquitylation K471 -1.404 _NK(gl)SLQMNDYK_
MED23 Ubiquitylation K679 -0.706 _FLSDPK(gl)TVLSAESEELNR_
MED23 Ubiquitylation K1088 -0.793 _LVDTMAGK(gl)SPGPFPNCDWR_
MED24 Phosphorylation S862 1.164 0.238 _LLS(ph)SNEDDANILSS(ph)PTDR_
MED24 Phosphorylation S863 2.413 _LLSS(ph)NEDDANILSS(ph)PTDR_
MED24 Phosphorylation S873 0.174 0.861 _LLSSNEDDANILSS(ph)PTDR_
MED26 Phosphorylation S7 -0.245 -0.270 _(ac)TAAPAS(ph)PQQIR_
MED26 Phosphorylation S361 1.616 _AGLS(ph)PAEPLLSR_
MED26 Phosphorylation S447 -0.042 _EPVRADS(ph)PVHMEQQSR_
MED27 Ubiquitylation K145 -0.804 _SANQMGVSAK(gl)R_
MED27 Ubiquitylation K275 1.039 0.452 _SYIK(gl)LFQAPCQR_
MED29 Ubiquitylation K82 -1.387 -0.029 _YK(gl)MLIPQLK_
MED29 Ubiquitylation K114 -0.415 _VAAQNLIQNTNIDNGQK(gl)SSDGPIQR_
MED29 Ubiquitylation K205 -0.300 _DIHTALLDCANK(gl)VTGK_
MED29 Ubiquitylation K209 -2.067 _VTGK(gl)TPAPPAGPGGTL_
MED30 Phosphorylation S2 -0.188 -0.097 _(ac)S(ph)TPPLAASGMAPGPFAGPQAQQAAR_
MED30 Phosphorylation T3 -0.188 -0.624 _(ac)ST(ph)PPLAASGMAPGPFAGPQAQQAAR_
MED4 Ubiquitylation K112 0.878 _DSDIQQLQK(gl)QLK_
MED4 Ubiquitylation K150 -0.369 _KGAISSEEIIK(gl)YAHR_
MED6 Ubiquitylation K51 -0.146 _TCNNEVVK(gl)MQR_
MED8 Phosphorylation S82 1.556 1.306 _NQVIIPLVLS(ph)PDRDEDLM(ox)R_
MED9 Ubiquitylation K134 -1.629 _TKNELLQK(gl)YK_
NCOA1 Phosphorylation S22 0.503 0.810 _KGS(ph)PCDTLASSTEK_
NCOA2 Phosphorylation S699 -0.159 -0.104 _LLQDSSS(ph)PVDLAK_
NCOA2 Phosphorylation S771 1.654 0.621 _LDS(ph)KTDPASNTK_
NCOA3 Phosphorylation S861 -0.217 -0.429 _AVS(ph)LDSPVSVGSSPPVK_
NCOA3 Phosphorylation S870 -0.416 -0.360 _AVS(ph)LDSPVSVGS(ph)SPPVK_
NCOA3 Phosphorylation S1333 -0.364 _VSS(ph)PPNAMMSSR_
NCOR1 Phosphorylation S1195 -0.029 0.716 _MPIEDS(ph)SPEKGREEAASK_
NCOR1 Phosphorylation S1196 0.087 0.141 _MPIEDSS(ph)PEKGR_
NCOR1 Phosphorylation S1472 0.700 0.536 _AQLS(ph)PGIYDDTSAR_
NCOR1 Phosphorylation S1977 -0.959 -0.974 _YETPSDAIEVIS(ph)PASSPAPPQEK_
NCOR1 Ubiquitylation K1998 -2.086 _LQTYQPEVVK(gl)ANQAENDPTR_
NCOR1 Phosphorylation S2120 0.148 0.154 _VS(ph)PENLVDK_
NCOR1 Phosphorylation S2151 -1.006 -0.922 _SHVSSEPYEPIS(ph)PPQVPVVHEK_
NCOR1 Phosphorylation S2184 0.120 0.226 _S(ph)PGSISYLPSFFTK_
NCOR1 Phosphorylation S2187 0.396 _SPGS(ph)ISYLPSFFTK_
NFYA Phosphorylation S326 -0.045 _EKDS(ph)PHMQDPNQADEEAMTQIIR_
NRF1 Phosphorylation S136 -0.407 -0.047 _VGQQAIVLCIS(ph)PSKPNPVFK_
NRF1 Ubiquitylation K267 -0.444 _TIVK(gl)NCYK_
PPARGC1B Phosphorylation S524 0.617 _ELGS(ph)PTDEDSGQDQQLLR_
SREBF1 Ubiquitylation K321 -0.637 _LAAGSK(gl)APASAQSR_
SREBF1 Ubiquitylation K579 -1.649 0.673 _K(gl)QADLDLAR_
SREBF2 Ubiquitylation K340 -0.521 _TTHNIIEK(gl)R_
SREBF2 Ubiquitylation K386 -0.496 _YLQQVNHK(gl)LR_
SREBF2 Phosphorylation S469 -0.456 _VKDEPDS(ph)PPVALGMVDR_
SREBF2 Ubiquitylation K579 -1.649 0.673 _K(gl)QADLDLAR_
SREBF2 Ubiquitylation K660 -0.584 _RATPATEAGFEDEAK(gl)TSAR_
SREBF2 Ubiquitylation K778 -0.770 _SWSVK(gl)SAAK_
SREBF2 Ubiquitylation K782 -0.435 _SAAK(gl)ESLYCAQR_
SREBF2 Ubiquitylation K822 -1.768 _AIESLVKPQAKK(gl)_
SREBF2 Ubiquitylation K865 -0.540 _SSVLK(gl)SALGPDIICR_
SREBF2 Ubiquitylation K1067 -1.490 _TTQSTK(gl)HGEVDAWPGQR_
TBL1X Ubiquitylation K102 -0.183 _DK(gl)LAQQQAAAAAAAAAAASQQGSAK_
TBL1XR1 Ubiquitylation K102 -0.183 _DK(gl)LAQQQAAAAAAAAAAASQQGSAK_
TEAD1 Phosphorylation S11 0.569 _(ac)MEPSSWSGSES(ph)PAENMER_
TEAD1 Ubiquitylation K50 1.259 0.615 _IILSDEGK(gl)MYGR_
TEAD1 Ubiquitylation K262 -0.150 _VCSFGK(gl)QVVEK_
TEAD2 Ubiquitylation K50 1.259 0.615 _IILSDEGK(gl)MYGR_
TEAD2 Ubiquitylation K262 -0.150 _VCSFGK(gl)QVVEK_
TEAD3 Phosphorylation S26 0.469 0.760 _(ac)ASNSWNASS(ph)SPGEAR_
TEAD3 Phosphorylation S27 0.325 0.153 _(ac)ASNSWNASSS(ph)PGEAREDGPEGLDK_
TEAD3 Ubiquitylation K50 1.259 0.615 _IILSDEGK(gl)MYGR_
TEAD3 Phosphorylation S182 -0.156 _FS(ph)PPSPLPQAVFSTSSR_
TEAD3 Ubiquitylation K262 -0.150 _VCSFGK(gl)QVVEK_
TEAD4 Ubiquitylation K50 1.259 0.615 _IILSDEGK(gl)MYGR_
TEAD4 Ubiquitylation K262 -0.150 _VCSFGK(gl)QVVEK_
TGS1 Phosphorylation S89 0.022 _GIGLDESELDS(ph)EAELMR_
TIAM2 Phosphorylation S447 -0.196 -1.197 _YS(ph)PTLASETSPVPEAR_
TIAM2 Phosphorylation T449 -0.489 _YSPT(ph)LASETSPVPEAR_
TIAM2 Phosphorylation S452 -0.571 _YSPT(ph)LAS(ph)ETSPVPEAR_
TXNRD1 Ubiquitylation K580 -0.043 -0.178 _IICNTK(gl)DNER_
YAP1 Phosphorylation S61 -0.064 0.017 _GDS(ph)ETDLEALFNAVMNPK_
YAP1 Phosphorylation T63 -0.159 -0.257 _GDSET(ph)DLEALFNAVM(ox)NPK_
YAP1 Phosphorylation T110 0.467 _QAST(ph)DAGTAGALTPQHVR_
YAP1 Phosphorylation S127 -1.544 _AHS(ph)SPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLR_
YAP1 Phosphorylation S131 -1.256 -1.096 _AHSSPAS(ph)LQLGAVSPGTLTPTGVVSGPAATPTAQHLR_
YAP1 Ubiquitylation K315 -0.002 _LQQLQMEK(gl)ER_
YAP1 Ubiquitylation K321 -1.043 _LK(gl)QQELLR_
YAP1 Ubiquitylation K342 -0.589 _NINPSTANSPK(gl)CQELALR_
YAP1 Phosphorylation S367 0.272 _SQLPTLEQDGGTQNPVSS(ph)PGMSQELR_
YAP1 Phosphorylation S397 -0.200 _DES(ph)TDSGLSM(ox)SSYSVPR_


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