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Query: ABCB4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ABCB4 1 5.673 -0.790 1.130 2.195

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ABCB4 Ubiquitylation K271 1.459 _TVIAFGGQK(gl)K_
ABCB4 Ubiquitylation K272 1.009 _TVIAFGGQKK(gl)_
ABCB4 Ubiquitylation K279 -0.087 0.047 _YNK(gl)NLEEAKR_
ABCB4 Ubiquitylation K826 -0.613 0.002 _LANDAAQVK(gl)GAIGSR_
ABCB4 Ubiquitylation K617 0.890 _GNHDELMK(gl)EK_
ABCB4 Ubiquitylation K1093 -1.090 _FYDPLAGK(gl)VLLDGK_

Background Information for ABCB4:


Pubmed-ABCB4 »
Uniprot-ABCB4 »
Biogrid-ABCB4 »
ProteomicsDB-ABCB4 »

Tumorportal-ABCB4 »
COSMIC-ABCB4 »
GenomeRNAi-ABCB4 »
Genecards-ABCB4


Protein-protein Interactions for ABCB4
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in ABCB4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members AAA+_ATPase IPR003593 0.38
Category members Zeta_toxin_domain IPR010488 0.33
Category members ABC1_TM_dom IPR011527 0.33
Category members ABC_ATPase_put IPR019195 0.32
Category members ABC_transporter-like IPR003439 0.15
Category members ABC_transptr_TM_dom IPR001140 0.06


Protein complexes (CORUM database) featuring ABCB4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ABCB4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0046581 intercellular canaliculus Database 0.15
Category members Pathway Pathway_756 KEGG_ABC_TRANSPORTERS 0 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0042626 ATPase activity, coupled to transmembrane movement of substances Database 0.09
Category members GO Category GO:0008559 xenobiotic-transporting ATPase activity Database 0.05
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_451 BIOCARTA_NUCLEARRS_PATHWAY 0 0
Category members Disease phenotype Intrahepatic_cholestasis_of_pregnancy Intrahepatic cholestasis of pregnancy Database 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0


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