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Query: FADS1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FADS1 0 1.757 -0.870 0.300

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FADS1 Ubiquitylation K251 1.457 _ILSVELGK(gl)QK_
FADS1 Ubiquitylation K106 0.142 _NK(gl)ELTDEFR_

Background Information for FADS1:


Pubmed-FADS1 »
Uniprot-FADS1 »
Biogrid-FADS1 »
ProteomicsDB-FADS1 »

Tumorportal-FADS1 »
COSMIC-FADS1 »
GenomeRNAi-FADS1 »
Genecards-FADS1


Protein-protein Interactions for FADS1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC22 Cat. description Hein, Mann, Cell 2015
Category members IP bait FADS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GABRE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRPR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTH1R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC18A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TACR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMCO3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FADS1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cyt_B5-like_heme/steroid-bd IPR001199 1.28
Category members Fatty_acid/sphinglp_desaturase IPR012171 0.17
Category members Fatty_acid_desaturase-1 IPR005804 0


Protein complexes (CORUM database) featuring FADS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FADS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_144 KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS 0 0.13
Category members Pathway Pathway_143 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM 0 0.07
Category members GO Category GO:0033559 unsaturated fatty acid metabolic process Database 0.07
Category members GO Category GO:0036109 alpha-linolenic acid metabolic process Database 0.07
Category members GO Category GO:0006636 unsaturated fatty acid biosynthetic process Database 0.07
Category members GO Category GO:0009744 response to sucrose Database 0.04
Category members GO Category GO:0005506 iron ion binding Database 0.04
Category members GO Category GO:0020037 heme binding Database 0.04
Category members GO Category GO:0009267 cellular response to starvation Database 0.03
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members GO Category GO:0000248 C-5 sterol desaturase activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0006633 fatty acid biosynthetic process Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0007584 response to nutrient Database 0
Category members GO Category GO:0008654 phospholipid biosynthetic process Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Database 0
Category members GO Category GO:0019369 arachidonic acid metabolic process Database 0
Category members GO Category GO:0032868 response to insulin Database 0
Category members GO Category GO:0033189 response to vitamin A Database 0
Category members GO Category GO:0043651 linoleic acid metabolic process Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0045595 regulation of cell differentiation Database 0
Category members GO Category GO:0046456 icosanoid biosynthetic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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