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Query: TIAM2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TIAM2 0 -0.405 -0.270 0.280
TIAM2 0 -0.405 -0.190 -0.090

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TIAM2 Phosphorylation T449 -0.489 _YSPT(ph)LASETSPVPEAR_
TIAM2 Phosphorylation S452 -0.571 _YSPT(ph)LAS(ph)ETSPVPEAR_
TIAM2 Phosphorylation S447 -0.196 -1.197 _YS(ph)PTLASETSPVPEAR_

Background Information for TIAM2:


Pubmed-TIAM2 »
Uniprot-TIAM2 »
Biogrid-TIAM2 »
ProteomicsDB-TIAM2 »

Tumorportal-TIAM2 »
COSMIC-TIAM2 »
GenomeRNAi-TIAM2 »
Genecards-TIAM2


Protein-protein Interactions for TIAM2
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in TIAM2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PDZ IPR001478 0.15
Category members PH_domain IPR001849 0.14
Category members HR1_rho-bd IPR011072 0.07
Category members DH-domain IPR000219 0.05
Category members Raf-like_ras-bd IPR003116 0


Protein complexes (CORUM database) featuring TIAM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TIAM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0030426 growth cone Database 1.61
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members GO Category GO:0043547 positive regulation of GTPase activity Database 0.21
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members GO Category GO:0035023 regulation of Rho protein signal transduction Database 0.17
Category members Pathway Pathway_1140 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 0 0.1
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0005089 Rho guanyl-nucleotide exchange factor activity Database 0.08
Category members GO Category GO:0030175 filopodium Database 0.05
Category members Pathway Pathway_1157 PID_RAC1_REG_PATHWAY 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_519 REACTOME_SIGNALING_BY_RHO_GTPASES 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members GO Category GO:0005057 receptor signaling protein activity Database 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0


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