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REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK
(Pathway_1140)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
ARHGEF18 1 -2.120 3.490
ARHGEF2 1 -0.650 0.360 -0.121 -0.287 0.319 0.984 0.013
ARHGEF11 1 -1.250 1.080
AKAP13 1 -0.260 0.000
BAD 0 -0.660 1.190
TRIO 0 -0.690 0.810 0.256 0.123
PLEKHG2 0 0.720 -1.130
MCF2 0 -1.610 1.980
FGD1 0 -0.610 1.420
ARHGEF17 0 -0.350 -0.300
ECT2 0 0.620 -0.960 -0.787
SOS1 0 0.500 -0.620 -0.570
ARHGEF6 0 0.570 -0.210
ARHGEF6 0 0.570 -0.210
ARHGEF16 0 1.070 -1.120
RAC1 0 -0.580 1.580 0.486 -0.364 -0.568
TIAM2 0 -0.270 0.280
TIAM2 0 -0.190 -0.090
OBSCN 0 -0.680 0.510
OBSCN 0 -0.170 0.030
OBSCN 0 1.520 -0.830
TIAM1 0 -0.620 0.220
ABR 0 -1.000 1.510
NET1 0 -0.590 -0.370
ARHGEF12 0 -0.650 0.190
ITSN1 0 -0.670 0.610
ITSN1 0 -0.670 0.610 0.287 0.672

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ABR Phosphorylation S72 -1.041 -1.433 _SQGGGDGVS(ph)PTPPEGLAPGVEAGK_
AKAP13 Phosphorylation S1407 0.033 _ENWCTIEPCPDAASLLAS(ph)KQSPECENFLDVGLGR_
AKAP13 Phosphorylation S1645 0.260 0.639 _VDS(ph)LVSLSEEDLESDQR_
AKAP13 Phosphorylation S1650 1.957 1.098 _VDSLVSLS(ph)EEDLESDQR_
AKAP13 Phosphorylation S1879 -0.267 -0.048 _S(ph)AVLLVDETATTPIFANR_
AKAP13 Phosphorylation S1932 0.162 0.318 _FLSHS(ph)TDSLNK_
AKAP13 Phosphorylation S2401 -0.038 _DMAECSTPLPEDCS(ph)PTHSPR_
AKAP13 Phosphorylation S2564 0.644 0.859 _S(ph)LSRPSSLIEQEK_
AKAP13 Phosphorylation S2566 0.600 0.289 _SLS(ph)RPSSLIEQEK_
AKAP13 Phosphorylation S2712 -1.063 _IPSFFPSPEEPPS(ph)PSAPSIAK_
AKAP13 Phosphorylation S2721 1.298 1.110 _S(ph)GSLDSELSVSPK_
AKAP13 Phosphorylation S2731 -0.105 0.196 _SGSLDSELSVS(ph)PK_
ARHGEF11 Phosphorylation S216 1.512 _LSLDS(ph)QEGDSGLDSGTER_
ARHGEF11 Phosphorylation S556 0.780 0.048 _SSSQSTFHIPLS(ph)PVEVKPGNVR_
ARHGEF11 Phosphorylation T668 -1.878 _SLENPT(ph)PPFT(ph)PK_
ARHGEF11 Phosphorylation S1155 -0.647 -0.776 _HQVLLEDPEQEGS(ph)AEEEELGVLPCPSTSLDGENR_
ARHGEF11 Phosphorylation T1292 0.389 0.509 _T(ph)RNSGIWESPELDR_
ARHGEF11 Phosphorylation S1295 0.556 0.668 _TRNS(ph)GIWESPELDR_
ARHGEF11 Phosphorylation S1458 1.017 2.592 _SLGGESS(ph)GGTTPVGSFHTEAAR_
ARHGEF11 Phosphorylation S1480 -0.293 _WTDGSLS(ph)PPAKEPLASDSR_
ARHGEF12 Phosphorylation S190 1.083 _ITS(ph)PVLMGEENNVVHNQK_
ARHGEF12 Phosphorylation S309 -0.158 -0.113 _TDCSSGDASRPSSDNADS(ph)PK_
ARHGEF12 Phosphorylation S341 1.105 0.912 _SETIQDTDTQSLVGS(ph)PSTR_
ARHGEF12 Phosphorylation S635 -0.423 _HLSTPSS(ph)VSPEPQDSAK_
ARHGEF12 Phosphorylation S637 -0.340 -0.384 _HLSTPSSVS(ph)PEPQDSAK_
ARHGEF12 Phosphorylation T736 -0.667 -0.391 _VTEHGT(ph)PKPFR_
ARHGEF12 Phosphorylation T1286 0.415 0.112 _T(ph)ASQGPQTDSVIQNSENIK_
ARHGEF12 Phosphorylation S1288 0.339 0.153 _TAS(ph)QGPQTDSVIQNSENIK_
ARHGEF16 Phosphorylation S6 1.170 _(ac)AQRHS(ph)DSSLEEK_
ARHGEF16 Phosphorylation S107 -0.357 0.678 _HQS(ph)FGAAVLSR_
ARHGEF16 Phosphorylation S230 0.538 0.191 _GLNTSQES(ph)DDDILDESSSPEGTQK_
ARHGEF17 Phosphorylation S420 0.033 -0.777 _SPS(ph)FGAGEGLLR_
ARHGEF17 Phosphorylation S764 0.611 _AATSEEPTGFSVDSNLLGSLS(ph)PK_
ARHGEF18 Phosphorylation S328 0.771 0.776 _QES(ph)LEEGSDR_
ARHGEF18 Phosphorylation S1103 -0.342 -0.217 _SLS(ph)PILPGR_
ARHGEF2 Phosphorylation S196 -0.074 0.190 _SVS(ph)TTNIAGHFNDESPLGLR_
ARHGEF2 Phosphorylation S208 -1.192 _SVSTTNIAGHFNDES(ph)PLGLR_
ARHGEF2 Phosphorylation S217 0.850 _ILS(ph)QSTDSLNMR_
ARHGEF2 Phosphorylation S219 0.334 0.620 _ILSQS(ph)TDSLNMR_
ARHGEF2 Ubiquitylation K397 -0.617 _LYK(gl)ELYAR_
ARHGEF2 Phosphorylation S689 2.510 1.206 _SES(ph)LESPR_
ARHGEF2 Phosphorylation S735 -0.212 _EPALPLEPDS(ph)GGNTSPGVTANGEAR_
ARHGEF2 Phosphorylation T739 -0.489 _EPALPLEPDSGGNT(ph)SPGVTANGEAR_
ARHGEF2 Phosphorylation S740 -0.461 -0.375 _EPALPLEPDSGGNTS(ph)PGVTANGEAR_
ARHGEF2 Phosphorylation S930 -0.782 -1.060 _S(ph)LPAGDALYLSFNPPQPSR_
ARHGEF2 Phosphorylation S976 0.649 0.809 _QELGS(ph)PEER_
ARHGEF6 Phosphorylation S225 -0.163 -0.076 _SSERPLS(ph)PK_
ARHGEF6 Phosphorylation S415 0.662 0.947 _M(ox)S(ph)GFIYQGK_
ARHGEF6 Phosphorylation S600 0.797 _S(ph)TAALEEDAQILK_
ARHGEF6 Phosphorylation T601 0.797 _S(ph)TAALEEDAQILK_
ARHGEF6 Phosphorylation S684 0.068 -0.061 _KDS(ph)IPQVLLPEEEKLIIEETR_
BAD Phosphorylation S74 -0.904 -0.452 _HS(ph)SYPAGTEDDEGM(ox)GEEPSPFR_
BAD Phosphorylation S75 -0.914 -0.660 _HSS(ph)YPAGTEDDEGMGEEPSPFR_
BAD Phosphorylation S97 0.056 _S(ph)RSAPPNLWAAQR_
BAD Phosphorylation S99 -0.299 0.161 _S(ph)APPNLWAAQR_
BAD Phosphorylation S118 1.277 1.089 _RM(ox)S(ph)DEFVDSFKK_
FGD1 Phosphorylation S48 -0.284 _RGS(ph)GSALGGPLDPQFVGPSDTSLGAAPGHR_
FGD1 Phosphorylation S50 -0.140 -0.134 _RGSGS(ph)ALGGPLDPQFVGPSDTSLGAAPGHR_
FGD1 Phosphorylation S82 -0.199 _VLPCGPS(ph)PQHHR_
FGD1 Phosphorylation S114 -0.776 -0.924 _S(ph)LSLDPGQSLEPHPEGPQR_
FGD1 Phosphorylation S116 -0.758 -0.450 _SLS(ph)LDPGQSLEPHPEGPQR_
FGD1 Phosphorylation S135 -0.194 _LRS(ph)DPGPPTETPSQRPSPLK_
FGD1 Phosphorylation S954 -0.708 -1.116 _GDTFCPGPTLSEDREMEEAPVAALGATAEPPES(ph)PQTR_
ITSN1 Phosphorylation S203 -0.497 -0.811 _AQS(ph)FDVASVPPVAEWAVPQSSR_
ITSN1 Phosphorylation S313 0.882 0.188 _S(ph)GSGISVISSTSVDQR_
ITSN1 Phosphorylation S315 0.675 0.750 _SGS(ph)GISVISSTSVDQR_
ITSN1 Ubiquitylation K569 0.570 _DSLVTLK(gl)R_
ITSN1 Ubiquitylation K583 0.151 _NMQFSNTPDSGVSLLHK(gl)K_
ITSN1 Ubiquitylation K584 -0.412 _NMQFSNTPDSGVSLLHKK(gl)_
ITSN1 Ubiquitylation K596 1.277 _LK(gl)EQLDALEK_
ITSN1 Phosphorylation S889 -0.357 -0.319 _TVSPGSVS(ph)PIHGQGQVVENLK_
ITSN1 Phosphorylation S904 -0.681 -0.729 _SAFTPATATGSSPS(ph)PVLGQGEK_
ITSN1 Phosphorylation S978 1.075 0.684 _STS(ph)MDSGSSESPASLK_
MCF2 Ubiquitylation K546 0.553 0.452 _(ac)VQM(ox)K(gl)TIQLK(gl)_
MCF2 Ubiquitylation K551 0.553 0.452 _(ac)VQM(ox)K(gl)TIQLK(gl)_
NET1 Phosphorylation S50 -0.104 -0.386 _RAS(ph)GLSTEGATGPSADTSGSELDGR_
NET1 Phosphorylation T82 -0.341 _GSSFT(ph)FLTPGPNWDFTLK_
NET1 Ubiquitylation K166 -2.339 _SPASAQK(gl)FSSR_
NET1 Ubiquitylation K223 -1.722 _GEQDLIEDLK(gl)LAR_
NET1 Ubiquitylation K310 -2.114 _ALLDQKK(gl)_
OBSCN Phosphorylation S1485 1.190 _LSFS(ph)SKVR_
OBSCN Phosphorylation S1486 0.964 1.070 _LSFSS(ph)KVR_
PLEKHG2 Phosphorylation S482 -0.019 -0.815 _RQS(ph)EPVKDPYVM(ox)FPQNAK_
PLEKHG2 Phosphorylation S610 -1.029 _GPS(ph)PLHVLEGLESSIAAEMPSIPCLTK_
PLEKHG2 Phosphorylation T1257 -1.223 _LESSDLT(ph)PPHS(ph)PPPSSR_
PLEKHG2 Phosphorylation S1261 -1.223 _LESSDLT(ph)PPHS(ph)PPPSSR_
RAC1 Ubiquitylation K115 -1.745 -0.215 _AK(gl)WYPEVR_
RAC1 Ubiquitylation K142 0.492 _LDLRDDK(gl)DTIEK_
RAC1 Ubiquitylation K152 0.099 -0.292 _K(gl)LTPITYPQGLAMAK_
RAC1 Ubiquitylation K166 -0.981 -0.655 _LTPITYPQGLAMAK(gl)EIGAVK_
RAC1 Ubiquitylation K172 1.026 0.412 _EIGAVK(gl)YLECSALTQR_
RAC1 Ubiquitylation K185 -0.113 0.578 _GLK(gl)TVFDEAIR_
RAC1 Ubiquitylation K202 -1.379 -1.447 _AVLCPPPVK(gl)KR_
RAC1 Ubiquitylation K203 -1.708 -1.447 _AVLCPPPVKK(gl)_
SOS1 Phosphorylation S1082 0.278 _IPESETESTASAPNS(ph)PR_
SOS1 Phosphorylation S1166 0.097 -0.094 _RPESAPAES(ph)SPSK_
TIAM1 Phosphorylation S231 0.453 0.331 _ANS(ph)LGDLYAQK_
TIAM1 Phosphorylation T1405 0.267 _T(ph)ESLPSSQQYVPFGGK_
TIAM1 Phosphorylation S1407 -0.862 -0.252 _TES(ph)LPSSQQYVPFGGK_
TIAM2 Phosphorylation S447 -0.196 -1.197 _YS(ph)PTLASETSPVPEAR_
TIAM2 Phosphorylation T449 -0.489 _YSPT(ph)LASETSPVPEAR_
TIAM2 Phosphorylation S452 -0.571 _YSPT(ph)LAS(ph)ETSPVPEAR_
TRIO Phosphorylation S1723 0.798 _S(ph)SMEMEGIFNHK_
TRIO Phosphorylation S1724 0.798 _S(ph)SMEMEGIFNHK_
TRIO Phosphorylation S2455 0.012 -0.418 _AGAAS(ph)PLNSPLSSAVPSLGK_
TRIO Phosphorylation S2459 0.534 _AGAAS(ph)PLNS(ph)PLSSAVPSLGK_


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