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Query: TRIO

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TRIO 0 1.999 -0.690 0.810 0.256 0.123

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TRIO Phosphorylation S1723 0.798 _S(ph)SMEMEGIFNHK_
TRIO Phosphorylation S1724 0.798 _S(ph)SMEMEGIFNHK_
TRIO Phosphorylation S2459 0.534 _AGAAS(ph)PLNS(ph)PLSSAVPSLGK_
TRIO Phosphorylation S2455 0.012 -0.418 _AGAAS(ph)PLNSPLSSAVPSLGK_

Background Information for TRIO:


Pubmed-TRIO »
Uniprot-TRIO »
Biogrid-TRIO »
ProteomicsDB-TRIO »

Tumorportal-TRIO »
COSMIC-TRIO »
GenomeRNAi-TRIO »
Genecards-TRIO


Protein-protein Interactions for TRIO
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MYC Cat. description Hein, Mann, Cell 2015
Category members IP bait PRDX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait STMN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZNF187 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZNF232 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TRIO
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members Ig-like_dom IPR007110 0.6
Category members Ig_sub IPR003599 0.43
Category members Ig_sub2 IPR003598 0.21
Category members PH_domain IPR001849 0.14
Category members Ig_I-set IPR013098 0.13
Category members DH-domain IPR000219 0.05
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members CRAL-TRIO_dom IPR001251 0
Category members SH3_domain IPR001452 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members LipoPS_kinase IPR010440 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring TRIO
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TRIO
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_548 BIOCARTA_RAC1_PATHWAY 0 0.3
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0035023 regulation of Rho protein signal transduction Database 0.17
Category members Pathway Pathway_1033 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING 0 0.14
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1140 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 0 0.1
Category members Pathway Pathway_1172 PID_RHOA_REG_PATHWAY 0 0.09
Category members GO Category GO:0005089 Rho guanyl-nucleotide exchange factor activity Database 0.08
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_486 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 0 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1157 PID_RAC1_REG_PATHWAY 0 0
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_519 REACTOME_SIGNALING_BY_RHO_GTPASES 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members Pathway Pathway_640 PID_NETRIN_PATHWAY 0 0
Category members Pathway Pathway_692 REACTOME_NETRIN1_SIGNALING 0 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway Database 0
Category members GO Category GO:0009103 lipopolysaccharide biosynthetic process Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0016773 phosphotransferase activity, alcohol group as acceptor Database 0


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