bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: ARHGEF12

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ARHGEF12 0 2.378 -0.650 0.190

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ARHGEF12 Phosphorylation S190 1.083 _ITS(ph)PVLMGEENNVVHNQK_
ARHGEF12 Phosphorylation S341 1.105 0.912 _SETIQDTDTQSLVGS(ph)PSTR_
ARHGEF12 Phosphorylation S1288 0.339 0.153 _TAS(ph)QGPQTDSVIQNSENIK_
ARHGEF12 Phosphorylation T1286 0.415 0.112 _T(ph)ASQGPQTDSVIQNSENIK_
ARHGEF12 Phosphorylation S309 -0.158 -0.113 _TDCSSGDASRPSSDNADS(ph)PK_
ARHGEF12 Phosphorylation S637 -0.340 -0.384 _HLSTPSSVS(ph)PEPQDSAK_
ARHGEF12 Phosphorylation T736 -0.667 -0.391 _VTEHGT(ph)PKPFR_
ARHGEF12 Phosphorylation S635 -0.423 _HLSTPSS(ph)VSPEPQDSAK_

Background Information for ARHGEF12:


Pubmed-ARHGEF12 »
Uniprot-ARHGEF12 »
Biogrid-ARHGEF12 »
ProteomicsDB-ARHGEF12 »

Tumorportal-ARHGEF12 »
COSMIC-ARHGEF12 »
GenomeRNAi-ARHGEF12 »
Genecards-ARHGEF12


Protein-protein Interactions for ARHGEF12
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ESPL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NIPSNAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1984 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYO6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRMT61A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ARHGEF12
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PDZ IPR001478 0.15
Category members PH_domain IPR001849 0.14
Category members Regulat_G_prot_signal_superfam IPR016137 0.05
Category members DH-domain IPR000219 0.05
Category members RGS-like_dom IPR015212 0


Protein complexes (CORUM database) featuring ARHGEF12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ARHGEF12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members Pathway Pathway_240 BIOCARTA_PAR1_PATHWAY 0 1.11
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_677 BIOCARTA_MYOSIN_PATHWAY 0 0.53
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members GO Category GO:0035023 regulation of Rho protein signal transduction Database 0.17
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1140 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 0 0.1
Category members Pathway Pathway_1172 PID_RHOA_REG_PATHWAY 0 0.09
Category members GO Category GO:0001664 G-protein coupled receptor binding Database 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0005089 Rho guanyl-nucleotide exchange factor activity Database 0.08
Category members GO Category GO:0038032 termination of G-protein coupled receptor signaling pathway Database 0.05
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members Pathway Pathway_1032 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 0 0
Category members Pathway Pathway_1035 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 0 0
Category members Pathway Pathway_519 REACTOME_SIGNALING_BY_RHO_GTPASES 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0


.

© Copyright Svejstrup Laboratory 2015