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Query: SOS1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SOS1 0 -0.386 0.500 -0.620 -0.570

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SOS1 Phosphorylation S1166 0.097 -0.094 _RPESAPAES(ph)SPSK_
SOS1 Phosphorylation S1082 0.278 _IPESETESTASAPNS(ph)PR_

Background Information for SOS1:


Pubmed-SOS1 »
Uniprot-SOS1 »
Biogrid-SOS1 »
ProteomicsDB-SOS1 »

Tumorportal-SOS1 »
COSMIC-SOS1 »
GenomeRNAi-SOS1 »
Genecards-SOS1


Protein-protein Interactions for SOS1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CRKL Cat. description Hein, Mann, Cell 2015
Category members IP bait GRB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SOS1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PH_domain IPR001849 0.14
Category members Histone_core_D IPR007125 0.12
Category members DH-domain IPR000219 0.05
Category members Histone-fold IPR009072 0.01
Category members Ras-like_Gua-exchang_fac_N IPR000651 0
Category members RASGEF_cat_dom IPR001895 0
Category members Ras_GEF_dom IPR023578 0


Protein complexes (CORUM database) featuring SOS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2480 CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) Database 0
Category members Corum 2547 PLC-gamma-1-SLP-76-SOS1-LAT complex Database 0
Category members Corum 2893 BCR-ABL (p210 fusion protein)-GRB2-SOS1 complex Database 0
Category members Corum 2917 Grb2-Sos complex, Fc receptor gamma-R1 stimulated Database 0
Category members Corum 2922 LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated Database 0


Categories featuring SOS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members Pathway Pathway_636 PID_PI3K_PLC_TRK_PATHWAY 0 1.85
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_583 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR 0 0.68
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_509 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 0 0.62
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members Pathway Pathway_528 REACTOME_SIGNALING_BY_FGFR_MUTANTS 0 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_408 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 0 0.32
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members Pathway Pathway_535 SIG_BCR_SIGNALING_PATHWAY 0 0.24
Category members Pathway Pathway_433 PID_ER_NONGENOMIC_PATHWAY 0 0.23
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members Disease phenotype NOONAN_SYNDROME NOONAN SYNDROME Database 0.19
Category members Pathway Pathway_534 BIOCARTA_GLEEVEC_PATHWAY 0 0.18
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members Pathway Pathway_705 PID_CD8_TCR_PATHWAY 0 0.17
Category members GO Category GO:0035023 regulation of Rho protein signal transduction Database 0.17
Category members Pathway Pathway_686 BIOCARTA_BCR_PATHWAY 0 0.16
Category members Pathway Pathway_685 PID_RAS_PATHWAY 0 0.14
Category members Pathway Pathway_694 REACTOME_SIGNALLING_TO_ERKS 0 0.13
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_532 PID_ERBB2_ERBB3_PATHWAY 0 0.13
Category members Pathway Pathway_546 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0 0.13
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members Pathway Pathway_1140 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 0 0.1
Category members Pathway Pathway_601 PID_IL2_1PATHWAY 0 0.1
Category members Pathway Pathway_578 BIOCARTA_EGF_PATHWAY 0 0.09
Category members Pathway Pathway_584 BIOCARTA_TPO_PATHWAY 0 0.08
Category members Pathway Pathway_503 REACTOME_IL_RECEPTOR_SHC_SIGNALING 0 0.08
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members GO Category GO:0005089 Rho guanyl-nucleotide exchange factor activity Database 0.08
Category members Pathway Pathway_1005 ST_ERK1_ERK2_MAPK_PATHWAY 0 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members Pathway Pathway_600 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_518 ST_G_ALPHA_I_PATHWAY 0 0.05
Category members Pathway Pathway_653 BIOCARTA_MET_PATHWAY 0 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members Pathway Pathway_1115 REACTOME_SOS_MEDIATED_SIGNALLING 0 0.04
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members Pathway Pathway_543 BIOCARTA_TCR_PATHWAY 0 0.03
Category members Pathway Pathway_630 BIOCARTA_PDGF_PATHWAY 0 0.03
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members Pathway Pathway_617 BIOCARTA_TFF_PATHWAY 0 0.02
Category members Pathway Pathway_639 BIOCARTA_HER2_PATHWAY 0 0.01
Category members Pathway Pathway_932 REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 0 0.01
Category members Pathway Pathway_1010 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 0 0
Category members Pathway Pathway_1031 REACTOME_SIGNALING_BY_ROBO_RECEPTOR 0 0
Category members Pathway Pathway_1058 REACTOME_SIGNAL_ATTENUATION 0 0
Category members Pathway Pathway_1066 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING 0 0
Category members Pathway Pathway_1070 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 0 0
Category members Pathway Pathway_1071 BIOCARTA_SPRY_PATHWAY 0 0
Category members Pathway Pathway_1072 BIOCARTA_ERK_PATHWAY 0 0
Category members Pathway Pathway_1073 KEGG_DORSO_VENTRAL_AXIS_FORMATION 0 0
Category members Pathway Pathway_1077 BIOCARTA_IL2_PATHWAY 0 0
Category members Pathway Pathway_1079 BIOCARTA_IL6_PATHWAY 0 0
Category members Pathway Pathway_1088 REACTOME_SHC_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_1091 REACTOME_FRS2_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_1095 BIOCARTA_IL3_PATHWAY 0 0
Category members Pathway Pathway_1108 REACTOME_SHC_RELATED_EVENTS 0 0
Category members Pathway Pathway_1109 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ 0 0
Category members Pathway Pathway_1111 REACTOME_SHC_MEDIATED_SIGNALLING 0 0
Category members Pathway Pathway_1112 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING 0 0
Category members Pathway Pathway_1113 REACTOME_REGULATION_OF_KIT_SIGNALING 0 0
Category members Pathway Pathway_1114 REACTOME_SIGNALLING_TO_RAS 0 0
Category members Pathway Pathway_1148 REACTOME_ACTIVATION_OF_RAC 0 0
Category members Pathway Pathway_1157 PID_RAC1_REG_PATHWAY 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_212 BIOCARTA_IGF1R_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_249 BIOCARTA_CREB_PATHWAY 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_387 ST_T_CELL_SIGNAL_TRANSDUCTION 0 0
Category members Pathway Pathway_410 ST_INTERLEUKIN_4_PATHWAY 0 0
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_500 PID_FCER1_PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_506 REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 0 0
Category members Pathway Pathway_512 REACTOME_IL_2_SIGNALING 0 0
Category members Pathway Pathway_515 ST_B_CELL_ANTIGEN_RECEPTOR 0 0
Category members Pathway Pathway_519 REACTOME_SIGNALING_BY_RHO_GTPASES 0 0
Category members Pathway Pathway_522 PID_KIT_PATHWAY 0 0
Category members Pathway Pathway_530 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_531 PID_PDGFRA_PATHWAY 0 0
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members Pathway Pathway_539 PID_LYMPH_ANGIOGENESIS_PATHWAY 0 0
Category members Pathway Pathway_540 PID_BCR_5PATHWAY 0 0
Category members Pathway Pathway_553 BIOCARTA_PTEN_PATHWAY 0 0
Category members Pathway Pathway_556 BIOCARTA_TRKA_PATHWAY 0 0
Category members Pathway Pathway_567 PID_IL2_STAT5_PATHWAY 0 0
Category members Pathway Pathway_569 PID_GMCSF_PATHWAY 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_577 BIOCARTA_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_585 PID_IL2_PI3K_PATHWAY 0 0
Category members Pathway Pathway_586 REACTOME_TIE2_SIGNALING 0 0
Category members Pathway Pathway_588 SA_TRKA_RECEPTOR 0 0
Category members Pathway Pathway_591 BIOCARTA_IL2RB_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_597 BIOCARTA_FCER1_PATHWAY 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_616 BIOCARTA_GH_PATHWAY 0 0
Category members Pathway Pathway_619 SA_PTEN_PATHWAY 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members Pathway Pathway_627 BIOCARTA_NGF_PATHWAY 0 0
Category members Pathway Pathway_632 BIOCARTA_IGF1_PATHWAY 0 0
Category members Pathway Pathway_633 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 0 0
Category members Pathway Pathway_643 PID_RET_PATHWAY 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_652 PID_IL6_7_PATHWAY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_657 PID_FGF_PATHWAY 0 0
Category members Pathway Pathway_659 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS 0 0
Category members Pathway Pathway_693 BIOCARTA_PYK2_PATHWAY 0 0
Category members Pathway Pathway_700 BIOCARTA_EPO_PATHWAY 0 0
Category members Pathway Pathway_703 PID_EPO_PATHWAY 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_930 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 0 0
Category members Pathway Pathway_931 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING 0 0
Category members Pathway Pathway_998 BIOCARTA_AT1R_PATHWAY 0 0
Category members Pathway Pathway_999 SA_B_CELL_RECEPTOR_COMPLEXES 0 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0005088 Ras guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0005100 Rho GTPase activator activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0032321 positive regulation of Rho GTPase activity Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway Database 0
Category members GO Category GO:0051057 positive regulation of small GTPase mediated signal transduction Database 0


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