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Query: ITSN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ITSN1 0 5.240 -0.670 0.610
ITSN1 0 5.240 -0.670 0.610 0.287 0.672

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ITSN1 Phosphorylation S315 0.675 0.750 _SGS(ph)GISVISSTSVDQR_
ITSN1 Phosphorylation S978 1.075 0.684 _STS(ph)MDSGSSESPASLK_
ITSN1 Ubiquitylation K569 0.570 _DSLVTLK(gl)R_
ITSN1 Phosphorylation S313 0.882 0.188 _S(ph)GSGISVISSTSVDQR_
ITSN1 Ubiquitylation K583 0.151 _NMQFSNTPDSGVSLLHK(gl)K_
ITSN1 Phosphorylation S889 -0.357 -0.319 _TVSPGSVS(ph)PIHGQGQVVENLK_
ITSN1 Ubiquitylation K584 -0.412 _NMQFSNTPDSGVSLLHKK(gl)_
ITSN1 Phosphorylation S904 -0.681 -0.729 _SAFTPATATGSSPS(ph)PVLGQGEK_
ITSN1 Phosphorylation S203 -0.497 -0.811 _AQS(ph)FDVASVPPVAEWAVPQSSR_
ITSN1 Ubiquitylation K596 1.277 _LK(gl)EQLDALEK_

Background Information for ITSN1:


Pubmed-ITSN1 »
Uniprot-ITSN1 »
Biogrid-ITSN1 »
ProteomicsDB-ITSN1 »

Tumorportal-ITSN1 »
COSMIC-ITSN1 »
GenomeRNAi-ITSN1 »
Genecards-ITSN1


Protein-protein Interactions for ITSN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RAD18 Cat. description Hein, Mann, Cell 2015
Category members IP bait TFG Cat. description Hein, Mann, Cell 2015
Category members IP bait ALOX5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DTX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LSR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCKIPSD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NECAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RUNDC3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ITSN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members PH_domain IPR001849 0.14
Category members SH3_2 IPR011511 0.08
Category members DH-domain IPR000219 0.05
Category members C2_dom IPR000008 0
Category members EPS15_homology IPR000261 0
Category members SH3_domain IPR001452 0
Category members EF_hand_dom IPR002048 0
Category members Spectrin_alpha_SH3 IPR013315 0


Protein complexes (CORUM database) featuring ITSN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ITSN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0032947 protein complex scaffold Database 0.82
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0042327 positive regulation of phosphorylation Database 0.52
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0019209 kinase activator activity Database 0.29
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0035023 regulation of Rho protein signal transduction Database 0.17
Category members Pathway Pathway_629 PID_EPHB_FWD_PATHWAY 0 0.14
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_1140 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 0 0.1
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0005089 Rho guanyl-nucleotide exchange factor activity Database 0.08
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0048488 synaptic vesicle endocytosis Database 0.05
Category members Pathway Pathway_293 PID_CDC42_REG_PATHWAY 0 0.05
Category members GO Category GO:0070064 proline-rich region binding Database 0.01
Category members Pathway Pathway_519 REACTOME_SIGNALING_BY_RHO_GTPASES 0 0
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0030139 endocytic vesicle Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0


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