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Query: ARHGEF6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ARHGEF6 0 1.609 0.570 -0.210

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ARHGEF6 Phosphorylation S415 0.662 0.947 _M(ox)S(ph)GFIYQGK_
ARHGEF6 Phosphorylation S600 0.797 _S(ph)TAALEEDAQILK_
ARHGEF6 Phosphorylation T601 0.797 _S(ph)TAALEEDAQILK_
ARHGEF6 Phosphorylation S684 0.068 -0.061 _KDS(ph)IPQVLLPEEEKLIIEETR_
ARHGEF6 Phosphorylation S225 -0.163 -0.076 _SSERPLS(ph)PK_

Background Information for ARHGEF6:


Pubmed-ARHGEF6 »
Uniprot-ARHGEF6 »
Biogrid-ARHGEF6 »
ProteomicsDB-ARHGEF6 »

Tumorportal-ARHGEF6 »
COSMIC-ARHGEF6 »
GenomeRNAi-ARHGEF6 »
Genecards-ARHGEF6


Protein-protein Interactions for ARHGEF6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARHGEF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARHGEF7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GIT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ICAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPXN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCKIPSD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RABGGTB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYNC Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ARHGEF6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members CH-domain IPR001715 0.63
Category members SM22_calponin IPR003096 0.45
Category members PH_domain IPR001849 0.14
Category members CAMSAP_CH IPR022613 0.13
Category members SH3_2 IPR011511 0.08
Category members DH-domain IPR000219 0.05
Category members SH3_domain IPR001452 0


Protein complexes (CORUM database) featuring ARHGEF6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5499 PARVB-ARHGEF6 complex Database 0.21
Category members Corum 5498 ILK-PARVB-ARHGEF6 complex Database 0.17


Categories featuring ARHGEF6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members Pathway Pathway_240 BIOCARTA_PAR1_PATHWAY 0 1.11
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0030032 lamellipodium assembly Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_677 BIOCARTA_MYOSIN_PATHWAY 0 0.53
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members GO Category GO:0043547 positive regulation of GTPase activity Database 0.21
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members Pathway Pathway_923 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS 0 0.18
Category members GO Category GO:0035023 regulation of Rho protein signal transduction Database 0.17
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_1140 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 0 0.1
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0005089 Rho guanyl-nucleotide exchange factor activity Database 0.08
Category members Pathway Pathway_293 PID_CDC42_REG_PATHWAY 0 0.05
Category members Disease phenotype X-linked_non-syndromic_intellectual_disability X-linked non-syndromic intellectual disability Database 0.01
Category members Pathway Pathway_1157 PID_RAC1_REG_PATHWAY 0 0
Category members Pathway Pathway_519 REACTOME_SIGNALING_BY_RHO_GTPASES 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members Pathway Pathway_925 REACTOME_CELL_JUNCTION_ORGANIZATION 0 0
Category members GO Category GO:0007254 JNK cascade Database 0


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