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Query: MED16

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MED16 1 -1.092 -0.070 -0.120 -0.498 0.991 1.893 -1.924 -1.039

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MED16 Ubiquitylation K817 -0.515 _TTAVK(gl)QWEQR_
MED16 Ubiquitylation K252 -0.659 _VCVSVVSEK(gl)CR_
MED16 Ubiquitylation K158 -0.972 _SGASSFGEK(gl)FSR_
MED16 Ubiquitylation K796 -1.345 _LHLGACPTEECK(gl)ACTR_

Background Information for MED16:


Pubmed-MED16 »
Uniprot-MED16 »
Biogrid-MED16 »
ProteomicsDB-MED16 »

Tumorportal-MED16 »
COSMIC-MED16 »
GenomeRNAi-MED16 »
Genecards-MED16


Protein-protein Interactions for MED16
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AURKA Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK8 Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FOSL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait MED12 Cat. description Hein, Mann, Cell 2015
Category members IP bait MED22 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2G Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAJC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MED16
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52


Protein complexes (CORUM database) featuring MED16
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 230 Mediator complex Database 0.76
Category members Corum 535 TRAP complex Database 0.76
Category members Corum 300 PC2 complex Database 0.53
Category members Corum 66 TRAP complex Database 0.46
Category members Corum 5450 Mediator complex Database 0.45
Category members Corum 301 SMCC complex Database 0.45
Category members Corum 547 SMCC complex Database 0.31
Category members Corum 441 TFTC-type histone acetyl transferase complex Database 0.2
Category members Corum 909 ARC92-Mediator complex Database 0.13
Category members Corum 910 CRSP-Mediator 2 complex Database 0.08
Category members Corum 548 DRIP complex Database 0.08
Category members Corum 549 DRIP complex Database 0.08


Categories featuring MED16
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0016592 mediator complex Database 0.53
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0003712 transcription cofactor activity Database 0.21
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members GO Category GO:0030375 thyroid hormone receptor coactivator activity Database 0.06
Category members GO Category GO:0046966 thyroid hormone receptor binding Database 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0030518 intracellular steroid hormone receptor signaling pathway Database 0
Category members GO Category GO:0042809 vitamin D receptor binding Database 0


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