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Query: HMGCR

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HMGCR 0 -2.139 0.240 0.010

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HMGCR Ubiquitylation K299 -1.680 -0.460 _VSLGLDENVSK(gl)R_
HMGCR Ubiquitylation K142 -0.522 _ASTLAK(gl)FALSSNSQDEVR_
HMGCR Ubiquitylation K381 -0.848 _NNQK(gl)CDSVEEETGINR_
HMGCR Ubiquitylation K633 -1.104 _LQK(gl)LHTSIAGR_
HMGCR Ubiquitylation K662 -1.291 _SGDAMGMNMISK(gl)GTEK_
HMGCR Ubiquitylation K886 -1.325 _INLQDLQGACTKK(gl)_
HMGCR Ubiquitylation K873 -1.345 _SK(gl)INLQDLQGACTKK_
HMGCR Ubiquitylation K502 -1.382 _K(gl)LSEPSSLQYLPYR_
HMGCR Ubiquitylation K885 -1.690 _SKINLQDLQGACTK(gl)K_
HMGCR Ubiquitylation K704 -1.716 _GK(gl)SVVCEAVIPAK(gl)VVR_
HMGCR Ubiquitylation K363 -1.750 _NPITSPVVTQKK(gl)_
HMGCR Ubiquitylation K715 -1.982 _SVVCEAVIPAK(gl)VVR_
HMGCR Ubiquitylation K248 -3.854 -2.107 _VLEEEENK(gl)PNPVTQR_
HMGCR Ubiquitylation K401 -3.050 _KVEVIK(gl)PLVAETDTPNR_

Background Information for HMGCR:


Pubmed-HMGCR »
Uniprot-HMGCR »
Biogrid-HMGCR »
ProteomicsDB-HMGCR »

Tumorportal-HMGCR »
COSMIC-HMGCR »
GenomeRNAi-HMGCR »
Genecards-HMGCR


Protein-protein Interactions for HMGCR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CD209 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GABRA6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR114 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCNS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTGIR Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HMGCR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SSD IPR000731 0.17
Category members Patched IPR003392 0.09


Protein complexes (CORUM database) featuring HMGCR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HMGCR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0051262 protein tetramerization Database 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Database 0.29
Category members GO Category GO:0048661 positive regulation of smooth muscle cell proliferation Database 0.24
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0010666 positive regulation of cardiac muscle cell apoptotic process Database 0.11
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members GO Category GO:0008158 hedgehog receptor activity Database 0.04
Category members GO Category GO:0005778 peroxisomal membrane Database 0.01
Category members Pathway Pathway_149 KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS 0 0
Category members Pathway Pathway_164 REACTOME_CHOLESTEROL_BIOSYNTHESIS 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members GO Category GO:0006695 cholesterol biosynthetic process Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0007584 response to nutrient Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0008299 isoprenoid biosynthetic process Database 0
Category members GO Category GO:0008542 visual learning Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0010664 negative regulation of striated muscle cell apoptotic process Database 0
Category members GO Category GO:0015936 coenzyme A metabolic process Database 0
Category members GO Category GO:0032874 positive regulation of stress-activated MAPK cascade Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043407 negative regulation of MAP kinase activity Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0045445 myoblast differentiation Database 0
Category members GO Category GO:0045908 negative regulation of vasodilation Database 0
Category members GO Category GO:0048643 positive regulation of skeletal muscle tissue development Database 0
Category members GO Category GO:0050661 NADP binding Database 0
Category members GO Category GO:0050662 coenzyme binding Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0061045 negative regulation of wound healing Database 0
Category members GO Category GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus Database 0
Category members GO Category GO:0070402 NADPH binding Database 0


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