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Query: MED1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MED1 1 2.680 0.780 -0.520 -1.530 -0.219

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MED1 Phosphorylation S664 3.368 _DNPAQDFSTLYGSS(ph)PLER_
MED1 Phosphorylation S1156 0.829 1.055 _NSSQSGGKPGSS(ph)PITK_
MED1 Phosphorylation S1223 1.061 1.013 _AKS(ph)PISSGSGGSHM(ox)SGTSSSSGM(ox)K_
MED1 Phosphorylation S1192 -0.792 _PSSLM(ox)NPSLSKPNIS(ph)PSHSRPPGGSDK_
MED1 Phosphorylation T1051 -1.201 -1.247 _SQT(ph)PPGVATPPIPK_
MED1 Phosphorylation T1057 -1.294 _SQT(ph)PPGVAT(ph)PPIPK_
MED1 Phosphorylation S771 -1.422 _LSS(ph)SDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLR_
MED1 Phosphorylation S1155 0.689 _NSSQSGGKPGS(ph)SPITK_
MED1 Phosphorylation S1433 -0.191 _NYGS(ph)PLISGSTPK_

Background Information for MED1:


Pubmed-MED1 »
Uniprot-MED1 »
Biogrid-MED1 »
ProteomicsDB-MED1 »

Tumorportal-MED1 »
COSMIC-MED1 »
GenomeRNAi-MED1 »
Genecards-MED1


Protein-protein Interactions for MED1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK8 Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MED12 Cat. description Hein, Mann, Cell 2015
Category members IP bait MED22 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2F Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2G Cat. description Hein, Mann, Cell 2015
Category members IP bait SMEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BIRC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NR1I3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCL1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MED1
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring MED1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2601 P-TEFb-BRD4-TRAP220 complex Database 1.23
Category members Corum 230 Mediator complex Database 0.76
Category members Corum 535 TRAP complex Database 0.76
Category members Corum 2600 BRD4 complex Database 0.63
Category members Corum 66 TRAP complex Database 0.46
Category members Corum 2639 HES1 promoter-Notch enhancer complex Database 0.45
Category members Corum 5450 Mediator complex Database 0.45
Category members Corum 301 SMCC complex Database 0.45
Category members Corum 867 TRAP-SMCC mediator complex Database 0.31
Category members Corum 547 SMCC complex Database 0.31
Category members Corum 441 TFTC-type histone acetyl transferase complex Database 0.2
Category members Corum 909 ARC92-Mediator complex Database 0.13
Category members Corum 548 DRIP complex Database 0.08
Category members Corum 549 DRIP complex Database 0.08
Category members Corum 232 ARC complex Database 0.05
Category members Corum 228 SMCC complex Database 0.01
Category members Corum 217 CRSP complex Database 0
Category members Corum 218 CRSP complex Database 0
Category members Corum 2626 CCNC-CDK8-MED1-MED6-MED7 xcomplex Database 0
Category members Corum 284 CRSP complex Database 0
Category members Corum 287 ARC-L complex Database 0
Category members Corum 288 ARC complex Database 0


Categories featuring MED1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members GO Category GO:0036033 mediator complex binding Database 1.23
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members GO Category GO:0016922 ligand-dependent nuclear receptor binding Database 0.89
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0006356 regulation of transcription from RNA polymerase I promoter Database 0.73
Category members Pathway Pathway_748 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION 0 0.66
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members GO Category GO:0016592 mediator complex Database 0.53
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0030224 monocyte differentiation Database 0.45
Category members GO Category GO:0035257 nuclear hormone receptor binding Database 0.44
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members Pathway Pathway_1176 BIOCARTA_PITX2_PATHWAY 0 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway Database 0.25
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_945 BIOCARTA_VDR_PATHWAY 0 0.22
Category members GO Category GO:0003712 transcription cofactor activity Database 0.21
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0035162 embryonic hemopoiesis Database 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity Database 0.12
Category members GO Category GO:0001047 core promoter binding Database 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0060745 mammary gland branching involved in pregnancy Database 0.11
Category members GO Category GO:0033598 mammary gland epithelial cell proliferation Database 0.09
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members GO Category GO:0071383 cellular response to steroid hormone stimulus Database 0.08
Category members GO Category GO:0001104 RNA polymerase II transcription cofactor activity Database 0.08
Category members GO Category GO:0070562 regulation of vitamin D receptor signaling pathway Database 0.07
Category members GO Category GO:0042789 mRNA transcription from RNA polymerase II promoter Database 0.07
Category members GO Category GO:0030375 thyroid hormone receptor coactivator activity Database 0.06
Category members GO Category GO:0042975 peroxisome proliferator activated receptor binding Database 0.05
Category members GO Category GO:0043010 camera-type eye development Database 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members GO Category GO:0033160 positive regulation of protein import into nucleus, translocation Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0035855 megakaryocyte development Database 0.02
Category members GO Category GO:0042974 retinoic acid receptor binding Database 0.02
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members GO Category GO:0046966 thyroid hormone receptor binding Database 0
Category members Pathway Pathway_156 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION 0 0
Category members Pathway Pathway_365 BIOCARTA_CARM_ER_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_755 PID_RXR_VDR_PATHWAY 0 0
Category members Pathway Pathway_929 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY 0 0
Category members Pathway Pathway_939 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION 0 0
Category members Pathway Pathway_940 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA 0 0
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001892 embryonic placenta development Database 0
Category members GO Category GO:0002088 lens development in camera-type eye Database 0
Category members GO Category GO:0003222 ventricular trabecula myocardium morphogenesis Database 0
Category members GO Category GO:0003406 retinal pigment epithelium development Database 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0006590 thyroid hormone generation Database 0
Category members GO Category GO:0006702 androgen biosynthetic process Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007595 lactation Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010839 negative regulation of keratinocyte proliferation Database 0
Category members GO Category GO:0030216 keratinocyte differentiation Database 0
Category members GO Category GO:0030331 estrogen receptor binding Database 0
Category members GO Category GO:0030518 intracellular steroid hormone receptor signaling pathway Database 0
Category members GO Category GO:0031490 chromatin DNA binding Database 0
Category members GO Category GO:0032993 protein-DNA complex Database 0
Category members GO Category GO:0033601 positive regulation of mammary gland epithelial cell proliferation Database 0
Category members GO Category GO:0035050 embryonic heart tube development Database 0
Category members GO Category GO:0035116 embryonic hindlimb morphogenesis Database 0
Category members GO Category GO:0035357 peroxisome proliferator activated receptor signaling pathway Database 0
Category members GO Category GO:0035729 cellular response to hepatocyte growth factor stimulus Database 0
Category members GO Category GO:0042809 vitamin D receptor binding Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0045444 fat cell differentiation Database 0
Category members GO Category GO:0045618 positive regulation of keratinocyte differentiation Database 0
Category members GO Category GO:0048821 erythrocyte development Database 0
Category members GO Category GO:0048822 enucleate erythrocyte development Database 0
Category members GO Category GO:0050693 LBD domain binding Database 0
Category members GO Category GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway Database 0
Category members GO Category GO:0060744 mammary gland branching involved in thelarche Database 0
Category members GO Category GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation Database 0
Category members GO Category GO:0070318 positive regulation of G0 to G1 transition Database 0
Category members GO Category GO:0070371 ERK1 and ERK2 cascade Database 0
Category members GO Category GO:0071364 cellular response to epidermal growth factor stimulus Database 0


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