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Query: SREBF2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SREBF2 0 -1.432 0.120 -0.140

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SREBF2 Ubiquitylation K579 -1.649 0.673 _K(gl)QADLDLAR_
SREBF2 Ubiquitylation K782 -0.435 _SAAK(gl)ESLYCAQR_
SREBF2 Phosphorylation S469 -0.456 _VKDEPDS(ph)PPVALGMVDR_
SREBF2 Ubiquitylation K386 -0.496 _YLQQVNHK(gl)LR_
SREBF2 Ubiquitylation K340 -0.521 _TTHNIIEK(gl)R_
SREBF2 Ubiquitylation K865 -0.540 _SSVLK(gl)SALGPDIICR_
SREBF2 Ubiquitylation K660 -0.584 _RATPATEAGFEDEAK(gl)TSAR_
SREBF2 Ubiquitylation K778 -0.770 _SWSVK(gl)SAAK_
SREBF2 Ubiquitylation K1067 -1.490 _TTQSTK(gl)HGEVDAWPGQR_
SREBF2 Ubiquitylation K822 -1.768 _AIESLVKPQAKK(gl)_

Background Information for SREBF2:


Pubmed-SREBF2 »
Uniprot-SREBF2 »
Biogrid-SREBF2 »
ProteomicsDB-SREBF2 »

Tumorportal-SREBF2 »
COSMIC-SREBF2 »
GenomeRNAi-SREBF2 »
Genecards-SREBF2


Protein-protein Interactions for SREBF2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CGRRF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRND Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-DPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NRG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC4A8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMCO3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNRF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SREBF2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bHLH_dom IPR011598 0.32


Protein complexes (CORUM database) featuring SREBF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SREBF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0032937 SREBP-SCAP-Insig complex Database 0.09
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members GO Category GO:0010886 positive regulation of cholesterol storage Database 0.05
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_959 SA_CASPASE_CASCADE 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0012507 ER to Golgi transport vesicle membrane Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0055098 response to low-density lipoprotein particle Database 0
Category members GO Category GO:0070888 E-box binding Database 0


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