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Query: HMGCS1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HMGCS1 1 0.261 -1.450 3.080 -0.209 0.030

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HMGCS1 Ubiquitylation K102 -1.761 -0.427 _LEVGTETIIDKSK(gl)_
HMGCS1 Ubiquitylation K100 -0.673 _LEVGTETIIDK(gl)SK_
HMGCS1 Ubiquitylation K273 -0.550 -0.790 _LVQK(gl)SLAR_
HMGCS1 Ubiquitylation K321 -0.588 -0.833 _AFMK(gl)ASSELFSQK_
HMGCS1 Ubiquitylation K409 -0.898 _ITASLCDLK(gl)SR_
HMGCS1 Ubiquitylation K330 -0.934 _ASSELFSQK(gl)TK_
HMGCS1 Phosphorylation S4 -1.161 -1.052 _PGS(ph)LPLNAEACWPK_
HMGCS1 Ubiquitylation K428 -1.720 _TGVAPDVFAENMK(gl)LR_
HMGCS1 Phosphorylation S495 -1.763 -1.842 _RPTPNDDTLDEGVGLVHSNIATEHIPS(ph)PAKK_
HMGCS1 Ubiquitylation K332 -0.326 _ASSELFSQKTK(gl)_

Background Information for HMGCS1:


Pubmed-HMGCS1 »
Uniprot-HMGCS1 »
Biogrid-HMGCS1 »
ProteomicsDB-HMGCS1 »

Tumorportal-HMGCS1 »
COSMIC-HMGCS1 »
GenomeRNAi-HMGCS1 »
Genecards-HMGCS1


Protein-protein Interactions for HMGCS1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK5R1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FSD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBD5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFYA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OR10H3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OR5F1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1R14C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC22A5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HMGCS1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Thiolase-like IPR016039 0.26
Category members HMG_CoA_synthase_euk IPR010122 0.22
Category members HMG_CoA_synth_N IPR013528 0.22
Category members HMG_CoA_synt_C_dom IPR013746 0.22


Protein complexes (CORUM database) featuring HMGCS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HMGCS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0016853 isomerase activity Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0004421 hydroxymethylglutaryl-CoA synthase activity Database 0.22
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members Pathway Pathway_39 PID_HNF3B_PATHWAY 0 0.08
Category members Pathway Pathway_19 KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION 0 0.04
Category members GO Category GO:0010243 response to organonitrogen compound Database 0.02
Category members GO Category GO:0009725 response to hormone Database 0.01
Category members Pathway Pathway_149 KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS 0 0
Category members Pathway Pathway_164 REACTOME_CHOLESTEROL_BIOSYNTHESIS 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_46 KEGG_BUTANOATE_METABOLISM 0 0
Category members GO Category GO:0001101 response to acid Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0006695 cholesterol biosynthetic process Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0008144 drug binding Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0008299 isoprenoid biosynthetic process Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0014074 response to purine-containing compound Database 0
Category members GO Category GO:0033197 response to vitamin E Database 0
Category members GO Category GO:0034698 response to gonadotropin Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0070723 response to cholesterol Database 0
Category members GO Category GO:0071372 cellular response to follicle-stimulating hormone stimulus Database 0
Category members GO Category GO:0071397 cellular response to cholesterol Database 0
Category members GO Category GO:0071407 cellular response to organic cyclic compound Database 0


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