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Query: ME1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ME1 0 0.428

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ME1 Ubiquitylation K512 0.582 -0.154 _DVSLK(gl)IAEK_
ME1 Ubiquitylation K422 -0.582 _AECSAEQCYK(gl)ITK_
ME1 Ubiquitylation K536 -1.965 _TATVYPEPQNK(gl)EAFVR_
ME1 Ubiquitylation K516 0.190 _IAEK(gl)IVK_

Background Information for ME1:


Pubmed-ME1 »
Uniprot-ME1 »
Biogrid-ME1 »
ProteomicsDB-ME1 »

Tumorportal-ME1 »
COSMIC-ME1 »
GenomeRNAi-ME1 »
Genecards-ME1


Protein-protein Interactions for ME1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EFNB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCRL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FTH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYPD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFYA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OAZ3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAC14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZSCAN12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ME1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Malic_OxRdtase IPR001891 0
Category members Malic_N_dom IPR012301 0
Category members Malic_NAD-bd IPR012302 0


Protein complexes (CORUM database) featuring ME1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ME1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0051287 NAD binding Database 1.6
Category members Pathway Pathway_16 KEGG_PYRUVATE_METABOLISM 0 1.34
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0051262 protein tetramerization Database 0.6
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0043531 ADP binding Database 0.27
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0009055 electron carrier activity Database 0.02
Category members GO Category GO:0009725 response to hormone Database 0.01
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_43 KEGG_PPAR_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0004470 malic enzyme activity Database 0
Category members GO Category GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity Database 0
Category members GO Category GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity Database 0
Category members GO Category GO:0006108 malate metabolic process Database 0
Category members GO Category GO:0006741 NADP biosynthetic process Database 0
Category members GO Category GO:0008948 oxaloacetate decarboxylase activity Database 0
Category members GO Category GO:0009743 response to carbohydrate Database 0
Category members GO Category GO:0030145 manganese ion binding Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050661 NADP binding Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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