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Query: NCOA3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NCOA3 0 -0.577 0.000 -0.330

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NCOA3 Phosphorylation S870 -0.416 -0.360 _AVS(ph)LDSPVSVGS(ph)SPPVK_
NCOA3 Phosphorylation S1333 -0.364 _VSS(ph)PPNAMMSSR_
NCOA3 Phosphorylation S861 -0.217 -0.429 _AVS(ph)LDSPVSVGSSPPVK_

Background Information for NCOA3:


Pubmed-NCOA3 »
Uniprot-NCOA3 »
Biogrid-NCOA3 »
ProteomicsDB-NCOA3 »

Tumorportal-NCOA3 »
COSMIC-NCOA3 »
GenomeRNAi-NCOA3 »
Genecards-NCOA3


Protein-protein Interactions for NCOA3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait STRN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM132A Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC5 Cat. description Hein, Mann, Cell 2015


Protein Domains in NCOA3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bHLH_dom IPR011598 0.32
Category members PAS_fold IPR013767 0.27
Category members PAS IPR000014 0.23
Category members Nuc_rcpt_coact IPR009110 0.16
Category members DUF1518 IPR010011 0
Category members Nuc_rcpt_coact_Ncoa-typ IPR014920 0
Category members SRC-1 IPR014935 0
Category members Nuclear_rcpt_coactivator IPR017426 0


Protein complexes (CORUM database) featuring NCOA3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 4 Multisubunit ACTR coactivator complex Database 0.31
Category members Corum 2727 SRC-3 complex Database 0.1
Category members Corum 2829 RSmad complex Database 0.06
Category members Corum 1054 ESR1-RELA-BCL3-NCOA3 complex Database 0
Category members Corum 2124 IKK-alpha--ER-alpha-AIB1 complex Database 0


Categories featuring NCOA3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members GO Category GO:0016573 histone acetylation Database 1.24
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members Pathway Pathway_1260 PID_ERB_GENOMIC_PATHWAY 0 1.04
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members GO Category GO:0016922 ligand-dependent nuclear receptor binding Database 0.89
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members Pathway Pathway_748 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION 0 0.66
Category members GO Category GO:0004402 histone acetyltransferase activity Database 0.56
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members GO Category GO:0035257 nuclear hormone receptor binding Database 0.44
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_945 BIOCARTA_VDR_PATHWAY 0 0.22
Category members Pathway Pathway_948 BIOCARTA_CARM1_PATHWAY 0 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_381 BIOCARTA_RARRXR_PATHWAY 0 0.08
Category members GO Category GO:0035264 multicellular organism growth Database 0.04
Category members GO Category GO:0046966 thyroid hormone receptor binding Database 0
Category members Pathway Pathway_156 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION 0 0
Category members Pathway Pathway_186 PID_HNF3A_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_939 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION 0 0
Category members Pathway Pathway_940 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA 0 0
Category members Pathway Pathway_946 PID_RETINOIC_ACID_PATHWAY 0 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0045618 positive regulation of keratinocyte differentiation Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0060068 vagina development Database 0
Category members GO Category GO:0060713 labyrinthine layer morphogenesis Database 0
Category members GO Category GO:0060744 mammary gland branching involved in thelarche Database 0


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