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Query: SREBF1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SREBF1 0 -0.976 0.540 -0.490

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SREBF1 Ubiquitylation K579 -1.649 0.673 _K(gl)QADLDLAR_
SREBF1 Ubiquitylation K321 -0.637 _LAAGSK(gl)APASAQSR_

Background Information for SREBF1:


Pubmed-SREBF1 »
Uniprot-SREBF1 »
Biogrid-SREBF1 »
ProteomicsDB-SREBF1 »

Tumorportal-SREBF1 »
COSMIC-SREBF1 »
GenomeRNAi-SREBF1 »
Genecards-SREBF1


Protein-protein Interactions for SREBF1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SREBF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SREBF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bHLH_dom IPR011598 0.32


Protein complexes (CORUM database) featuring SREBF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SREBF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0033762 response to glucagon Database 0.35
Category members GO Category GO:0071398 cellular response to fatty acid Database 0.35
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0031065 positive regulation of histone deacetylation Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0032570 response to progesterone Database 0.1
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members GO Category GO:0050796 regulation of insulin secretion Database 0.06
Category members GO Category GO:0008610 lipid biosynthetic process Database 0.05
Category members GO Category GO:0009267 cellular response to starvation Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_156 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_755 PID_RXR_VDR_PATHWAY 0 0
Category members Pathway Pathway_959 SA_CASPASE_CASCADE 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0010867 positive regulation of triglyceride biosynthetic process Database 0
Category members GO Category GO:0012507 ER to Golgi transport vesicle membrane Database 0
Category members GO Category GO:0019217 regulation of fatty acid metabolic process Database 0
Category members GO Category GO:0032094 response to food Database 0
Category members GO Category GO:0032526 response to retinoic acid Database 0
Category members GO Category GO:0032810 sterol response element binding Database 0
Category members GO Category GO:0033993 response to lipid Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0045542 positive regulation of cholesterol biosynthetic process Database 0
Category members GO Category GO:0046676 negative regulation of insulin secretion Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0051591 response to cAMP Database 0
Category members GO Category GO:0070542 response to fatty acid Database 0


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