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Query: MED23

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MED23 1 0.200 0.740 -0.420 0.242 1.739 -1.089 0.014

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MED23 Ubiquitylation K679 -0.706 _FLSDPK(gl)TVLSAESEELNR_
MED23 Ubiquitylation K1088 -0.793 _LVDTMAGK(gl)SPGPFPNCDWR_
MED23 Ubiquitylation K471 -1.404 _NK(gl)SLQMNDYK_

Background Information for MED23:


Pubmed-MED23 »
Uniprot-MED23 »
Biogrid-MED23 »
ProteomicsDB-MED23 »

Tumorportal-MED23 »
COSMIC-MED23 »
GenomeRNAi-MED23 »
Genecards-MED23


Protein-protein Interactions for MED23
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCNC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NR1I3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCN3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MED23
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring MED23
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 230 Mediator complex Database 0.76
Category members Corum 5450 Mediator complex Database 0.45
Category members Corum 441 TFTC-type histone acetyl transferase complex Database 0.2
Category members Corum 909 ARC92-Mediator complex Database 0.13
Category members Corum 900 Mediator complex 2 Database 0.12
Category members Corum 910 CRSP-Mediator 2 complex Database 0.08
Category members Corum 548 DRIP complex Database 0.08
Category members Corum 549 DRIP complex Database 0.08
Category members Corum 232 ARC complex Database 0.05
Category members Corum 898 Mediator complex 1 Database 0.04
Category members Corum 217 CRSP complex Database 0
Category members Corum 218 CRSP complex Database 0
Category members Corum 229 NAT complex Database 0
Category members Corum 284 CRSP complex Database 0
Category members Corum 287 ARC-L complex Database 0
Category members Corum 288 ARC complex Database 0
Category members Corum 895 hMediator complex (MED23, CDK8, CCNC, MED7) Database 0
Category members Corum 896 hMediator complex (MED23, CDK8, CCNC) Database 0


Categories featuring MED23
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0016592 mediator complex Database 0.53
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Disease phenotype Autosomal_recessive_non-syndromic_intellectual_disability Autosomal recessive non-syndromic intellectual disability Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0


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