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Query: NCOA2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NCOA2 1 2.275 -0.210 -0.230

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NCOA2 Phosphorylation S771 1.654 0.621 _LDS(ph)KTDPASNTK_
NCOA2 Phosphorylation S699 -0.159 -0.104 _LLQDSSS(ph)PVDLAK_

Background Information for NCOA2:


Pubmed-NCOA2 »
Uniprot-NCOA2 »
Biogrid-NCOA2 »
ProteomicsDB-NCOA2 »

Tumorportal-NCOA2 »
COSMIC-NCOA2 »
GenomeRNAi-NCOA2 »
Genecards-NCOA2


Protein-protein Interactions for NCOA2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AFF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAGEA10 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBE2K Cat. description Hein, Mann, Cell 2015
Category members IP bait MAGEA10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NR1I3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLA Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NCOA2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bHLH_dom IPR011598 0.32
Category members PAS_fold IPR013767 0.27
Category members PAS IPR000014 0.23
Category members Nuc_rcpt_coact IPR009110 0.16
Category members DUF1518 IPR010011 0
Category members Nuc_rcpt_coact_Ncoa-typ IPR014920 0
Category members SRC-1 IPR014935 0
Category members Nuclear_rcpt_coactivator IPR017426 0


Protein complexes (CORUM database) featuring NCOA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2728 SRC-1 complex Database 0.2
Category members Corum 2727 SRC-3 complex Database 0.1


Categories featuring NCOA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members Pathway Pathway_1260 PID_ERB_GENOMIC_PATHWAY 0 1.04
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members GO Category GO:0016922 ligand-dependent nuclear receptor binding Database 0.89
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members Pathway Pathway_748 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION 0 0.66
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members GO Category GO:0004402 histone acetyltransferase activity Database 0.56
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0035257 nuclear hormone receptor binding Database 0.44
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_945 BIOCARTA_VDR_PATHWAY 0 0.22
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity Database 0.12
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_381 BIOCARTA_RARRXR_PATHWAY 0 0.08
Category members GO Category GO:0030375 thyroid hormone receptor coactivator activity Database 0.06
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_156 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_939 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION 0 0
Category members Pathway Pathway_940 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA 0 0
Category members Pathway Pathway_946 PID_RETINOIC_ACID_PATHWAY 0 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0


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