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Query: CCNC

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CCNC 0 0.126 0.760 -0.860

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CCNC Ubiquitylation K117 0.126 _LIAAATSVLK(gl)TR_

Background Information for CCNC:


Pubmed-CCNC »
Uniprot-CCNC »
Biogrid-CCNC »
ProteomicsDB-CCNC »

Tumorportal-CCNC »
COSMIC-CCNC »
GenomeRNAi-CCNC »
Genecards-CCNC


Protein-protein Interactions for CCNC
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK8 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LZIC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CCNC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cyclin_N IPR006671 0
Category members Cyclin-like IPR013763 0


Protein complexes (CORUM database) featuring CCNC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3065 RNA polymerase II complex, chromatin structure modifying Database 1.26
Category members Corum 3066 RNA polymerase II complex, chromatin structure modifying Database 0.92
Category members Corum 230 Mediator complex Database 0.76
Category members Corum 535 TRAP complex Database 0.76
Category members Corum 3064 RNA polymerase II complex, chromatin structure modifying Database 0.64
Category members Corum 3067 RNA polymerase II complex, incomplete (CDK8 complex), chromatin structure modifying Database 0.63
Category members Corum 301 SMCC complex Database 0.45
Category members Corum 3060 RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying Database 0.35
Category members Corum 547 SMCC complex Database 0.31
Category members Corum 3061 RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying Database 0.18
Category members Corum 898 Mediator complex 1 Database 0.04
Category members Corum 228 SMCC complex Database 0.01
Category members Corum 229 NAT complex Database 0
Category members Corum 2626 CCNC-CDK8-MED1-MED6-MED7 xcomplex Database 0
Category members Corum 287 ARC-L complex Database 0
Category members Corum 288 ARC complex Database 0
Category members Corum 895 hMediator complex (MED23, CDK8, CCNC, MED7) Database 0
Category members Corum 896 hMediator complex (MED23, CDK8, CCNC) Database 0


Categories featuring CCNC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016591 DNA-directed RNA polymerase II, holoenzyme Database 1.52
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0016592 mediator complex Database 0.53
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity Database 0.13
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_808 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION 0 0.08
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0


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