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Query: HDAC3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HDAC3 0 0.716 -0.790 1.070

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HDAC3 Phosphorylation S424 -0.354 _GPEENYSRPEAPNEFYDGDHDNDKES(ph)DVEI_

Background Information for HDAC3:


Pubmed-HDAC3 »
Uniprot-HDAC3 »
Biogrid-HDAC3 »
ProteomicsDB-HDAC3 »

Tumorportal-HDAC3 »
COSMIC-HDAC3 »
GenomeRNAi-HDAC3 »
Genecards-HDAC3


Protein-protein Interactions for HDAC3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC88A Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait AKD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C4orf26 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C6orf141 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CARD8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCT7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait F9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HNRPLL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYZL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFPL4B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBL1Y Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRMT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZSCAN5A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HDAC3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members His_deacetylse_1 IPR003084 0.12
Category members His_deacetylse IPR000286 0
Category members His_deacetylse_dom IPR023801 0


Protein complexes (CORUM database) featuring HDAC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5614 Emerin complex 32 Database 1.48
Category members Corum 1413 NCOR1 complex Database 0.65
Category members Corum 1505 NCOR2 complex Database 0.15
Category members Corum 741 NCOR-HDAC3 complex Database 0.13
Category members Corum 5426 ANCO1-HDAC3 complex Database 0.04
Category members Corum 1188 SMRT core complex Database 0
Category members Corum 15 NCOR complex Database 0
Category members Corum 2183 Kaiso-NCOR complex Database 0
Category members Corum 5609 Emerin regulatory complex Database 0
Category members Corum 58 SMRT complex Database 0
Category members Corum 752 SMRT core complex Database 0


Categories featuring HDAC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0045786 negative regulation of cell cycle Database 0.93
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0005876 spindle microtubule Database 0.68
Category members Pathway Pathway_748 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION 0 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members GO Category GO:0040014 regulation of multicellular organism growth Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_1143 PID_HDAC_CLASSII_PATHWAY 0 0.3
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0051225 spindle assembly Database 0.25
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members GO Category GO:0032922 circadian regulation of gene expression Database 0.21
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members Pathway Pathway_381 BIOCARTA_RARRXR_PATHWAY 0 0.08
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_1047 BIOCARTA_RELA_PATHWAY 0 0.01
Category members Pathway Pathway_156 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION 0 0
Category members Pathway Pathway_365 BIOCARTA_CARM_ER_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_940 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA 0 0
Category members Pathway Pathway_946 PID_RETINOIC_ACID_PATHWAY 0 0
Category members GO Category GO:0000118 histone deacetylase complex Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0004407 histone deacetylase activity Database 0
Category members GO Category GO:0006476 protein deacetylation Database 0
Category members GO Category GO:0007346 regulation of mitotic cell cycle Database 0
Category members GO Category GO:0016575 histone deacetylation Database 0
Category members GO Category GO:0030332 cyclin binding Database 0
Category members GO Category GO:0031490 chromatin DNA binding Database 0
Category members GO Category GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) Database 0
Category members GO Category GO:0033558 protein deacetylase activity Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0046329 negative regulation of JNK cascade Database 0
Category members GO Category GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) Database 0
Category members GO Category GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) Database 0


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