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Query: TXNRD1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TXNRD1 0 -0.420 -0.400 -0.200

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TXNRD1 Ubiquitylation K580 -0.043 -0.178 _IICNTK(gl)DNER_

Background Information for TXNRD1:


Pubmed-TXNRD1 »
Uniprot-TXNRD1 »
Biogrid-TXNRD1 »
ProteomicsDB-TXNRD1 »

Tumorportal-TXNRD1 »
COSMIC-TXNRD1 »
GenomeRNAi-TXNRD1 »
Genecards-TXNRD1


Protein-protein Interactions for TXNRD1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDO1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDIA6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXNRD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TXNRD1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Thioredoxin-like_fold IPR012336 0.16
Category members Glutaredoxin IPR002109 0.06
Category members Pyr_OxRdtase_NAD-bd_dom IPR001327 0.03
Category members Pyridine_nuc-diS_OxRdtase_2 IPR000103 0
Category members Hg_reductase IPR000815 0
Category members GIDA-rel IPR002218 0
Category members mOase_FAD-bd IPR002938 0
Category members FAD_bind_dom IPR003953 0
Category members Pyr_nucl-diS_OxRdtase_dimer IPR004099 0
Category members CHP00275_HI0933-like IPR004792 0
Category members Thioredoxin/glutathione_Rdtase IPR006338 0
Category members FAD_pyr_nucl-diS_OxRdtase IPR013027 0
Category members FAD/NAD-linked_Rdtase_dimer IPR016156 0
Category members Pyr_nucl-diS_OxRdtase_FAD/NAD IPR023753 0


Protein complexes (CORUM database) featuring TXNRD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TXNRD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0010942 positive regulation of cell death Database 0.82
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0010269 response to selenium ion Database 0.65
Category members GO Category GO:0051262 protein tetramerization Database 0.6
Category members GO Category GO:0008033 tRNA processing Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0050660 flavin adenine dinucleotide binding Database 0.12
Category members GO Category GO:0001707 mesoderm formation Database 0.11
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0045454 cell redox homeostasis Database 0.05
Category members GO Category GO:0009055 electron carrier activity Database 0.02
Category members GO Category GO:0048678 response to axon injury Database 0.01
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_274 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members GO Category GO:0001890 placenta development Database 0
Category members GO Category GO:0004791 thioredoxin-disulfide reductase activity Database 0
Category members GO Category GO:0006749 glutathione metabolic process Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0015035 protein disulfide oxidoreductase activity Database 0
Category members GO Category GO:0015949 nucleobase-containing small molecule interconversion Database 0
Category members GO Category GO:0016174 NAD(P)H oxidase activity Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor Database 0
Category members GO Category GO:0042744 hydrogen peroxide catabolic process Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0045340 mercury ion binding Database 0
Category members GO Category GO:0050661 NADP binding Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0070995 NADPH oxidation Database 0
Category members GO Category GO:0071280 cellular response to copper ion Database 0
Category members GO Category GO:0071455 cellular response to hyperoxia Database 0


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