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Query: MED12

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MED12 0 -4.343 -0.180 -0.500 -1.501 -0.491

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MED12 Ubiquitylation K531 -0.272 _AMVVAKLLEK(gl)_
MED12 Ubiquitylation K429 -0.439 _EIEQQIK(gl)ER_
MED12 Ubiquitylation K1682 -0.745 _EGLQVSTK(gl)QK_
MED12 Phosphorylation S635 -1.278 -0.801 _GDLAFGAPGPRPPS(ph)PFDDPADDPEHK_
MED12 Ubiquitylation K1684 -0.960 _EGLQVSTK(gl)QK_
MED12 Ubiquitylation K1001 -1.092 _VK(gl)NTIYCNVEPSESNMR_
MED12 Ubiquitylation K1661 -1.781 _DVITCEPQGSLIDTK(gl)GNK_

Background Information for MED12:


Pubmed-MED12 »
Uniprot-MED12 »
Biogrid-MED12 »
ProteomicsDB-MED12 »

Tumorportal-MED12 »
COSMIC-MED12 »
GenomeRNAi-MED12 »
Genecards-MED12


Protein-protein Interactions for MED12
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK8 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait MED12 Cat. description Hein, Mann, Cell 2015
Category members IP bait MED22 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCAPH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MED12
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Mediator_Med12 IPR019035 0
Category members Mediator_Med12_catenin-bd IPR021989 0
Category members Mediator_Med12_LCEWAV IPR021990 0


Protein complexes (CORUM database) featuring MED12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 230 Mediator complex Database 0.76
Category members Corum 535 TRAP complex Database 0.76
Category members Corum 2600 BRD4 complex Database 0.63
Category members Corum 66 TRAP complex Database 0.46
Category members Corum 301 SMCC complex Database 0.45
Category members Corum 547 SMCC complex Database 0.31
Category members Corum 441 TFTC-type histone acetyl transferase complex Database 0.2
Category members Corum 909 ARC92-Mediator complex Database 0.13
Category members Corum 548 DRIP complex Database 0.08
Category members Corum 549 DRIP complex Database 0.08
Category members Corum 232 ARC complex Database 0.05
Category members Corum 287 ARC-L complex Database 0
Category members Corum 288 ARC complex Database 0


Categories featuring MED12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members GO Category GO:0014044 Schwann cell development Database 0.62
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0016592 mediator complex Database 0.53
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0003712 transcription cofactor activity Database 0.21
Category members GO Category GO:0014003 oligodendrocyte development Database 0.21
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity Database 0.12
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members GO Category GO:0001104 RNA polymerase II transcription cofactor activity Database 0.08
Category members Disease phenotype X-linked_intellectual_disability_with_marfanoid_habitus X-linked intellectual disability with marfanoid habitus Database 0.05
Category members GO Category GO:0060071 Wnt signaling pathway, planar cell polarity pathway Database 0.02
Category members Disease phenotype X-linked_non-syndromic_intellectual_disability X-linked non-syndromic intellectual disability Database 0.01
Category members GO Category GO:0046966 thyroid hormone receptor binding Database 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members GO Category GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding Database 0
Category members GO Category GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0030178 negative regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0030518 intracellular steroid hormone receptor signaling pathway Database 0
Category members GO Category GO:0042809 vitamin D receptor binding Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0


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