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Query: APOA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
APOA1 0 -3.959 0.850 -0.420 -3.959

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for APOA1:


Pubmed-APOA1 »
Uniprot-APOA1 »
Biogrid-APOA1 »
ProteomicsDB-APOA1 »

Tumorportal-APOA1 »
COSMIC-APOA1 »
GenomeRNAi-APOA1 »
Genecards-APOA1


Protein-protein Interactions for APOA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CEP135 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAPSS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ALDH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX19B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX31 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GDPD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GOT1L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPK6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UPF3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VCAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF558 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in APOA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ApoA1_A4_E IPR000074 0


Protein complexes (CORUM database) featuring APOA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring APOA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_90 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 0 0.88
Category members Pathway Pathway_920 REACTOME_AMYLOIDS 0 0.68
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0030325 adrenal gland development Database 0.52
Category members GO Category GO:0006656 phosphatidylcholine biosynthetic process Database 0.45
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0018206 peptidyl-methionine modification Database 0.3
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0007603 phototransduction, visible light Database 0.25
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members GO Category GO:0030300 regulation of intestinal cholesterol absorption Database 0.18
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Disease phenotype AMYLOIDOSIS_FAMILIAL_VISCERAL AMYLOIDOSIS FAMILIAL VISCERAL Database 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0001523 retinoid metabolic process Database 0.1
Category members GO Category GO:0002740 negative regulation of cytokine secretion involved in immune response Database 0.1
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members Pathway Pathway_39 PID_HNF3B_PATHWAY 0 0.08
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0015485 cholesterol binding Database 0.04
Category members GO Category GO:0001932 regulation of protein phosphorylation Database 0.04
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0008211 glucocorticoid metabolic process Database 0.04
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_43 KEGG_PPAR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_490 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 0 0
Category members Pathway Pathway_491 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT 0 0
Category members Pathway Pathway_492 REACTOME_LIPOPROTEIN_METABOLISM 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_716 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT 0 0
Category members Pathway Pathway_757 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS 0 0
Category members Pathway Pathway_758 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT 0 0
Category members Disease phenotype APOLIPOPROTEIN_A-I_DEFICIENCY APOLIPOPROTEIN A-I DEFICIENCY Database 0
Category members Disease phenotype HYPOALPHALIPOPROTEINEMIA_PRIMARY HYPOALPHALIPOPROTEINEMIA PRIMARY Database 0
Category members Disease phenotype TANGIER_DISEASE TANGIER DISEASE Database 0
Category members GO Category GO:0001540 beta-amyloid binding Database 0
Category members GO Category GO:0001935 endothelial cell proliferation Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0005319 lipid transporter activity Database 0
Category members GO Category GO:0005543 phospholipid binding Database 0
Category members GO Category GO:0005548 phospholipid transporter activity Database 0
Category members GO Category GO:0005788 endoplasmic reticulum lumen Database 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0006695 cholesterol biosynthetic process Database 0
Category members GO Category GO:0006869 lipid transport Database 0
Category members GO Category GO:0007584 response to nutrient Database 0
Category members GO Category GO:0008035 high-density lipoprotein particle binding Database 0
Category members GO Category GO:0008289 lipid binding Database 0
Category members GO Category GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway Database 0
Category members GO Category GO:0010873 positive regulation of cholesterol esterification Database 0
Category members GO Category GO:0014012 peripheral nervous system axon regeneration Database 0
Category members GO Category GO:0015914 phospholipid transport Database 0
Category members GO Category GO:0017127 cholesterol transporter activity Database 0
Category members GO Category GO:0018158 protein oxidation Database 0
Category members GO Category GO:0019915 lipid storage Database 0
Category members GO Category GO:0030139 endocytic vesicle Database 0
Category members GO Category GO:0030301 cholesterol transport Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0032489 regulation of Cdc42 protein signal transduction Database 0
Category members GO Category GO:0033344 cholesterol efflux Database 0
Category members GO Category GO:0033700 phospholipid efflux Database 0
Category members GO Category GO:0034115 negative regulation of heterotypic cell-cell adhesion Database 0
Category members GO Category GO:0034190 apolipoprotein receptor binding Database 0
Category members GO Category GO:0034191 apolipoprotein A-I receptor binding Database 0
Category members GO Category GO:0034361 very-low-density lipoprotein particle Database 0
Category members GO Category GO:0034364 high-density lipoprotein particle Database 0
Category members GO Category GO:0034366 spherical high-density lipoprotein particle Database 0
Category members GO Category GO:0034375 high-density lipoprotein particle remodeling Database 0
Category members GO Category GO:0034380 high-density lipoprotein particle assembly Database 0
Category members GO Category GO:0034384 high-density lipoprotein particle clearance Database 0
Category members GO Category GO:0034774 secretory granule lumen Database 0
Category members GO Category GO:0042157 lipoprotein metabolic process Database 0
Category members GO Category GO:0042158 lipoprotein biosynthetic process Database 0
Category members GO Category GO:0042632 cholesterol homeostasis Database 0
Category members GO Category GO:0043534 blood vessel endothelial cell migration Database 0
Category members GO Category GO:0043691 reverse cholesterol transport Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0050713 negative regulation of interleukin-1 beta secretion Database 0
Category members GO Category GO:0050728 negative regulation of inflammatory response Database 0
Category members GO Category GO:0051345 positive regulation of hydrolase activity Database 0
Category members GO Category GO:0051346 negative regulation of hydrolase activity Database 0
Category members GO Category GO:0051347 positive regulation of transferase activity Database 0
Category members GO Category GO:0055091 phospholipid homeostasis Database 0
Category members GO Category GO:0055102 lipase inhibitor activity Database 0
Category members GO Category GO:0060192 negative regulation of lipase activity Database 0
Category members GO Category GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity Database 0
Category members GO Category GO:0060761 negative regulation of response to cytokine stimulus Database 0
Category members GO Category GO:0070328 triglyceride homeostasis Database 0
Category members GO Category GO:0070508 cholesterol import Database 0


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