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Query: SMAD4

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMAD4 0 0.091 0.420 -0.390 0.020 0.556 -0.485

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for SMAD4:


Pubmed-SMAD4 »
Uniprot-SMAD4 »
Biogrid-SMAD4 »
ProteomicsDB-SMAD4 »

Tumorportal-SMAD4 »
COSMIC-SMAD4 »
GenomeRNAi-SMAD4 »
Genecards-SMAD4


Protein-protein Interactions for SMAD4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LHX4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMAD4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SMAD_FHA_domain IPR008984 0.86
Category members SMAD_dom_Dwarfin-type IPR001132 0
Category members MAD_homology1_Dwarfin-type IPR003619 0
Category members MAD_homology_MH1 IPR013019 0
Category members Interferon_reg_factor-3 IPR019471 0


Protein complexes (CORUM database) featuring SMAD4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3739 SKI-SMAD2-SMAD4 pentameric complex Database 0.33
Category members Corum 3753 CREBBP-SMAD2-SMAD4 pentameric complex Database 0.33
Category members Corum 2707 SMAD3-SMAD4-FOXO3-FOXG1 complex Database 0.32
Category members Corum 3206 SMAD4-SKI-NCOR complex Database 0.31
Category members Corum 2706 SMAD3-SMAD4-SP1 complex Database 0.11
Category members Corum 2708 SMAD3-SMAD4-cJUN complex Database 0.11
Category members Corum 2754 JUND-FOSB-SMAD3-SMAD4 complex Database 0.11
Category members Corum 2760 SMAD3-SMAD4-FOXO3 complex Database 0.11
Category members Corum 2829 RSmad complex Database 0.06
Category members Corum 2761 SMAD3-SMAD4-FOXO1 complex Database 0.05
Category members Corum 2762 SMAD3-SMAD4-FOXO4 complex Database 0.04
Category members Corum 1474 SMAD3/4-E2F4/5-p107-DP1 complex Database 0
Category members Corum 2692 SMAD3-SMAD4-cJun-cFos complex Database 0
Category members Corum 2705 SMAD3-SMAD4-CTCF protein-DNA complex Database 0
Category members Corum 2834 SMAD4-SMAD2-SMAD3 complex Database 0
Category members Corum 3038 SMAD2-SMAD4-FAST1 complex Database 0
Category members Corum 3740 SKI-SMAD3-SMAD4 pentameric complex Database 0
Category members Corum 3754 CREBBP-SMAD3-SMAD4 pentameric complex Database 0
Category members Corum 3959 SMAD3-SMAD4-cSKI, TGF(beta)-dependent Database 0


Categories featuring SMAD4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_995 PID_ALK1_PATHWAY 0 0.69
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members GO Category GO:0007498 mesoderm development Database 0.58
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Disease phenotype COLORECTAL_CANCER COLORECTAL CANCER Database 0.29
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation Database 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members GO Category GO:0030509 BMP signaling pathway Database 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0010718 positive regulation of epithelial to mesenchymal transition Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_941 BIOCARTA_WNT_PATHWAY 0 0.08
Category members Pathway Pathway_808 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION 0 0.08
Category members Pathway Pathway_823 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY 0 0.07
Category members Disease phenotype Familial_pancreatic_carcinoma Familial pancreatic carcinoma Database 0.06
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0009952 anterior/posterior pattern specification Database 0.06
Category members GO Category GO:0007492 endoderm development Database 0.06
Category members GO Category GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway Database 0.06
Category members GO Category GO:0030513 positive regulation of BMP signaling pathway Database 0.05
Category members Pathway Pathway_1131 PID_SMAD2_3PATHWAY 0 0.04
Category members Disease phenotype HEREDITARY_HEMORRHAGIC_TELANGIECTASIA HEREDITARY HEMORRHAGIC TELANGIECTASIA Database 0.04
Category members Pathway Pathway_1128 BIOCARTA_TGFB_PATHWAY 0 0.04
Category members Pathway Pathway_1211 REACTOME_SIGNALING_BY_BMP 0 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048663 neuron fate commitment Database 0.02
Category members GO Category GO:0005518 collagen binding Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1044 BIOCARTA_NTHI_PATHWAY 0 0
Category members Pathway Pathway_1133 PID_BMP_PATHWAY 0 0
Category members Pathway Pathway_1209 PID_ALK2_PATHWAY 0 0
Category members Pathway Pathway_1210 REACTOME_SIGNALING_BY_NODAL 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_637 BIOCARTA_CTCF_PATHWAY 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members Pathway Pathway_903 BIOCARTA_TOB1_PATHWAY 0 0
Category members Disease phenotype Generalized_juvenile_polyposis/juvenile_polyposis_coli Generalized juvenile polyposis/juvenile polyposis coli Database 0
Category members GO Category GO:0000987 core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0000988 protein binding transcription factor activity Database 0
Category members GO Category GO:0001076 RNA polymerase II transcription factor binding transcription factor activity Database 0
Category members GO Category GO:0001085 RNA polymerase II transcription factor binding Database 0
Category members GO Category GO:0001658 branching involved in ureteric bud morphogenesis Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001702 gastrulation with mouth forming second Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation Database 0
Category members GO Category GO:0003279 cardiac septum development Database 0
Category members GO Category GO:0003360 brainstem development Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007183 SMAD protein complex assembly Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0014033 neural crest cell differentiation Database 0
Category members GO Category GO:0017015 regulation of transforming growth factor beta receptor signaling pathway Database 0
Category members GO Category GO:0032444 activin responsive factor complex Database 0
Category members GO Category GO:0032525 somite rostral/caudal axis specification Database 0
Category members GO Category GO:0032909 regulation of transforming growth factor beta2 production Database 0
Category members GO Category GO:0036302 atrioventricular canal development Database 0
Category members GO Category GO:0042118 endothelial cell activation Database 0
Category members GO Category GO:0042177 negative regulation of protein catabolic process Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048729 tissue morphogenesis Database 0
Category members GO Category GO:0048733 sebaceous gland development Database 0
Category members GO Category GO:0048859 formation of anatomical boundary Database 0
Category members GO Category GO:0051098 regulation of binding Database 0
Category members GO Category GO:0060391 positive regulation of SMAD protein import into nucleus Database 0
Category members GO Category GO:0060395 SMAD protein signal transduction Database 0
Category members GO Category GO:0060548 negative regulation of cell death Database 0
Category members GO Category GO:0060956 endocardial cell differentiation Database 0
Category members GO Category GO:0070411 I-SMAD binding Database 0
Category members GO Category GO:0070412 R-SMAD binding Database 0
Category members GO Category GO:0071141 SMAD protein complex Database 0


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