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Query: E2F4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
E2F4 0 -3.813 0.930 -0.810

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
E2F4 Phosphorylation S16 -2.158 -1.655 _(ac)AEAGPQAPPPPGTPS(ph)R_
E2F4 Phosphorylation T14 -2.100 _(ac)AEAGPQAPPPPGT(ph)PSR_

Background Information for E2F4:


Pubmed-E2F4 »
Uniprot-E2F4 »
Biogrid-E2F4 »
ProteomicsDB-E2F4 »

Tumorportal-E2F4 »
COSMIC-E2F4 »
GenomeRNAi-E2F4 »
Genecards-E2F4


Protein-protein Interactions for E2F4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GMNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1984 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POMC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFDP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFDP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in E2F4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members E2F_TDP IPR003316 0.45


Protein complexes (CORUM database) featuring E2F4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5117 pRb2/p130-multimolecular complex (DNMT1, E2F4, SuV39H1, HDAC1, RBL2) Database 0.23
Category members Corum 5159 E2F4-p107-cyclinE complex Database 0.02
Category members Corum 1474 SMAD3/4-E2F4/5-p107-DP1 complex Database 0
Category members Corum 1661 E2F4-p107-cyclinA complex Database 0
Category members Corum 2975 SMAD3-E2F4/5-p107-DP1 complex Database 0
Category members Corum 5099 RB1(hypophosphorylated)-E2F4 complex Database 0
Category members Corum 5118 pRb2/p130-multimolecular complex (RB2, E2F4, HDAC1, SUV39H1, P300) Database 0
Category members Corum 5160 E2F4-p130 complex Database 0
Category members Corum 5596 LINC complex, quiescent cells Database 0


Categories featuring E2F4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Database 0.34
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_1171 SA_REG_CASCADE_OF_CYCLIN_EXPR 0 0.1
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_808 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION 0 0.08
Category members GO Category GO:0008361 regulation of cell size Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members Pathway Pathway_1097 BIOCARTA_ETS_PATHWAY 0 0
Category members Pathway Pathway_869 REACTOME_G0_AND_EARLY_G1 0 0
Category members GO Category GO:0002064 epithelial cell development Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006884 cell volume homeostasis Database 0
Category members GO Category GO:0008015 blood circulation Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0042384 cilium assembly Database 0


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