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Query: HDAC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HDAC1 1 8.867 -1.980 4.450
HDAC1 1 8.867 -1.980 4.450 -0.122 0.307 0.969 0.094 0.191

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HDAC1 Phosphorylation S409 1.326 1.144 _ISICS(ph)SDKR_
HDAC1 Phosphorylation S410 1.326 1.144 _ISICS(ph)SDKR_
HDAC1 Ubiquitylation K89 0.749 -0.241 _SIRPDNMSEYSK(gl)QMQR_
HDAC1 Ubiquitylation K66 -0.593 _ANAEEMTK(gl)YHSDDYIK_
HDAC1 Ubiquitylation K412 0.642 -0.744 _ISICSSDK(gl)R_
HDAC1 Phosphorylation S393 -1.133 -1.144 _M(ox)LPHAPGVQM(ox)QAIPEDAIPEES(ph)GDEDEDDPDKR_
HDAC1 Ubiquitylation K74 0.620 -1.473 _YHSDDYIK(gl)FLR_
HDAC1 Ubiquitylation K50 0.036 _K(gl)MEIYRPHK_

Background Information for HDAC1:


Pubmed-HDAC1 »
Uniprot-HDAC1 »
Biogrid-HDAC1 »
ProteomicsDB-HDAC1 »

Tumorportal-HDAC1 »
COSMIC-HDAC1 »
GenomeRNAi-HDAC1 »
Genecards-HDAC1


Protein-protein Interactions for HDAC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK2AP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ELMSAN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM60A Cat. description Hein, Mann, Cell 2015
Category members IP bait GATAD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HMG20A Cat. description Hein, Mann, Cell 2015
Category members IP bait L3MBTL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAX Cat. description Hein, Mann, Cell 2015
Category members IP bait MBD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYC Cat. description Hein, Mann, Cell 2015
Category members IP bait PHF12 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAP30 Cat. description Hein, Mann, Cell 2015
Category members IP bait SIN3A Cat. description Hein, Mann, Cell 2015
Category members IP bait SIN3B Cat. description Hein, Mann, Cell 2015
Category members IP bait ZMYND8 Cat. description Hein, Mann, Cell 2015
Category members IP bait BRMS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf87 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C22orf31 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C9orf41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDYL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYBRD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait E2F6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM60A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GATAD2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GATAD2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HMG20A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HMG20B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ING2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBD3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MORF4L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCGF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHF20L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBBP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RING1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RYBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF219 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HDAC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members His_deacetylse_1 IPR003084 0.12
Category members His_deacetylse IPR000286 0
Category members His_deacetylse_dom IPR023801 0


Protein complexes (CORUM database) featuring HDAC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 282 SNF2h-cohesin-NuRD complex Database 6.11
Category members Corum 778 LARC complex (LCR-associated remodeling complex) Database 5.04
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 739 SIN3-ING1b complex II Database 4.24
Category members Corum 659 MeCP1 complex Database 4.17
Category members Corum 685 MeCP1 complex Database 4.17
Category members Corum 714 BRM-SIN3A complex Database 4.02
Category members Corum 642 CtBP complex Database 3.6
Category members Corum 62 MeCP1 complex Database 3.53
Category members Corum 646 HDAC1-associated protein complex Database 3.34
Category members Corum 649 HDAC1-associated core complex cII Database 3.34
Category members Corum 61 Mi2/NuRD complex Database 2.87
Category members Corum 614 NRD complex (Nucleosome remodeling and deacetylation complex) Database 2.26
Category members Corum 888 MTA2 complex Database 2.24
Category members Corum 632 Anti-HDAC2 complex Database 2.11
Category members Corum 2721 HCF-1 complex Database 2.08
Category members Corum 3048 mSin3A complex Database 1.84
Category members Corum 691 SIN3-SAP25 complex Database 1.77
Category members Corum 743 SIN3-SAP25 complex Database 1.77
Category members Corum 591 SAP complex (Sin3-associated protein complex) Database 1.75
Category members Corum 1495 PID complex Database 1.68
Category members Corum 5614 Emerin complex 32 Database 1.48
Category members Corum 283 Sin3 complex Database 1.47
Category members Corum 54 SIN3 complex Database 1.47
Category members Corum 732 SIN3 complex Database 1.47
Category members Corum 738 SIN3-ING1b complex I Database 1.47
Category members Corum 596 SIN3-HDAC-SAP30-ARID4 complex Database 1.42
Category members Corum 695 SIN3-HDAC-SAP30-ARID4 complex Database 1.42
Category members Corum 698 SIN3-HDAC-SAP30-ARID4 complex Database 1.42
Category members Corum 643 CtBP core complex Database 1.41
Category members Corum 592 SAP complex (Sin3-associated protein complex) Database 1.33
Category members Corum 749 MeCP2-SIN3A-HDAC complex Database 1.25
Category members Corum 5184 SWI/SNF chromatin-remodeling complex Database 1.23
Category members Corum 634 XFIM complex Database 1.15
Category members Corum 49 DNMT3B complex Database 1.05
Category members Corum 5695 TIP5-DNMT-HDAC1 complex Database 0.98
Category members Corum 3167 NCOR-SIN3-HDAC-HESX1 complex Database 0.94
Category members Corum 2814 BRCA1-HDAC1-HDAC2 complex Database 0.85
Category members Corum 648 HDAC1-associated core complex cI Database 0.75
Category members Corum 2851 ING2 complex Database 0.74
Category members Corum 3053 mSin3A-HDAC1-HDAC2 complex Database 0.72
Category members Corum 3263 HERP1/HEY2-NCOR-SIN3A complex Database 0.68
Category members Corum 41 Mi-2/NuRD-MTA2 complex Database 0.67
Category members Corum 585 Mi2/NuRD-BCL6-MTA3 complex Database 0.67
Category members Corum 696 BRMS1-SIN3-HDAC complex Database 0.66
Category members Corum 633 anti-BHC110 complex Database 0.53
Category members Corum 636 BHC complex Database 0.53
Category members Corum 3156 CBF1-HDAC1-SMRT complex Database 0.52
Category members Corum 747 NCOR-SIN3-HDAC1 complex Database 0.52
Category members Corum 3269 RB1-HDAC1-BRG1 complex Database 0.49
Category members Corum 1492 BHC110 complex Database 0.39
Category members Corum 620 CoREST-HDAC complex Database 0.34
Category members Corum 871 BRAF53-BRCA2 complex Database 0.34
Category members Corum 1470 pRb2/p130-multimolecular complex (DNMT1, E2F5, SuV39H1, HDAC1, RBL2) Database 0.23
Category members Corum 5117 pRb2/p130-multimolecular complex (DNMT1, E2F4, SuV39H1, HDAC1, RBL2) Database 0.23
Category members Corum 1488 DNMT1-RB1-HDAC1-E2F1 complex Database 0.2
Category members Corum 3853 Rb-HDAC1 complex Database 0.2
Category members Corum 626 LSD1 complex Database 0.17
Category members Corum 1505 NCOR2 complex Database 0.15
Category members Corum 3961 SMAD3-cSKI-SIN3A-HDAC1 complex Database 0.08
Category members Corum 3149 NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex Database 0.04
Category members Corum 1159 p33ING1b-HDAC1 complex Database 0
Category members Corum 1471 pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300) Database 0
Category members Corum 3044 SKI-NCOR1-SIN3A-HDAC1 complex Database 0
Category members Corum 5118 pRb2/p130-multimolecular complex (RB2, E2F4, HDAC1, SUV39H1, P300) Database 0
Category members Corum 5609 Emerin regulatory complex Database 0
Category members Corum 5870 FE65-TSHZ3-HDAC1 complex Database 0


Categories featuring HDAC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_1254 PID_RANBP2_PATHWAY 0 1.33
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0016581 NuRD complex Database 1.15
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members GO Category GO:0045786 negative regulation of cell cycle Database 0.93
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members GO Category GO:0061198 fungiform papilla formation Database 0.68
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0070933 histone H4 deacetylation Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_54 BIOCARTA_MTA3_PATHWAY 0 0.36
Category members GO Category GO:0001103 RNA polymerase II repressing transcription factor binding Database 0.36
Category members GO Category GO:0016580 Sin3 complex Database 0.35
Category members GO Category GO:0060766 negative regulation of androgen receptor signaling pathway Database 0.35
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members Pathway Pathway_1176 BIOCARTA_PITX2_PATHWAY 0 0.29
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members Pathway Pathway_945 BIOCARTA_VDR_PATHWAY 0 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members GO Category GO:0060789 hair follicle placode formation Database 0.17
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0043922 negative regulation by host of viral transcription Database 0.12
Category members GO Category GO:0001047 core promoter binding Database 0.11
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_941 BIOCARTA_WNT_PATHWAY 0 0.08
Category members Pathway Pathway_808 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION 0 0.08
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members Pathway Pathway_823 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY 0 0.07
Category members GO Category GO:0001106 RNA polymerase II transcription corepressor activity Database 0.06
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_1144 BIOCARTA_MEF2D_PATHWAY 0 0
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_365 BIOCARTA_CARM_ER_PATHWAY 0 0
Category members Pathway Pathway_550 PID_IL3_PATHWAY 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_869 REACTOME_G0_AND_EARLY_G1 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_946 PID_RETINOIC_ACID_PATHWAY 0 0
Category members GO Category GO:0000118 histone deacetylase complex Database 0
Category members GO Category GO:0004407 histone deacetylase activity Database 0
Category members GO Category GO:0006476 protein deacetylation Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009913 epidermal cell differentiation Database 0
Category members GO Category GO:0010870 positive regulation of receptor biosynthetic process Database 0
Category members GO Category GO:0016575 histone deacetylation Database 0
Category members GO Category GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) Database 0
Category members GO Category GO:0033558 protein deacetylase activity Database 0
Category members GO Category GO:0033613 activating transcription factor binding Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0042733 embryonic digit morphogenesis Database 0
Category members GO Category GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) Database 0
Category members GO Category GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) Database 0
Category members GO Category GO:0061029 eyelid development in camera-type eye Database 0
Category members GO Category GO:0070932 histone H3 deacetylation Database 0


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