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Query: SP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SP1 0 3.335 0.404 0.333 0.650

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SP1 Phosphorylation S2 0.834 1.114 _(ac)S(ph)DQDHSMDEMTAVVK_
SP1 Phosphorylation S7 0.586 0.217 _(ac)SDQDHS(ph)MDEMTAVVK_
SP1 Phosphorylation S59 -0.217 -0.135 _SSSTGSSSSTGGGGQESQPS(ph)PLALLAATCSR_
SP1 Phosphorylation S56 -0.154 _SSSTGSSSSTGGGGQES(ph)QPSPLALLAATCSR_

Background Information for SP1:


Pubmed-SP1 »
Uniprot-SP1 »
Biogrid-SP1 »
ProteomicsDB-SP1 »

Tumorportal-SP1 »
COSMIC-SP1 »
GenomeRNAi-SP1 »
Genecards-SP1


Protein-protein Interactions for SP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015


Protein Domains in SP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92


Protein complexes (CORUM database) featuring SP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2721 HCF-1 complex Database 2.08
Category members Corum 2706 SMAD3-SMAD4-SP1 complex Database 0.11
Category members Corum 2237 SP1-MCAF2 complex Database 0
Category members Corum 2679 p53-SP1 complex Database 0


Categories featuring SP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members GO Category GO:0001889 liver development Database 0.51
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0001103 RNA polymerase II repressing transcription factor binding Database 0.36
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0043923 positive regulation by host of viral transcription Database 0.27
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members Pathway Pathway_566 BIOCARTA_HCMV_PATHWAY 0 0.18
Category members GO Category GO:0060216 definitive hemopoiesis Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_698 BIOCARTA_CALCINEURIN_PATHWAY 0 0.11
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_808 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION 0 0.08
Category members Pathway Pathway_39 PID_HNF3B_PATHWAY 0 0.08
Category members GO Category GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding Database 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0060136 embryonic process involved in female pregnancy Database 0.04
Category members GO Category GO:0048596 embryonic camera-type eye morphogenesis Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_186 PID_HNF3A_PATHWAY 0 0
Category members Pathway Pathway_419 PID_IL4_2PATHWAY 0 0
Category members Pathway Pathway_440 PID_FRA_PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_567 PID_IL2_STAT5_PATHWAY 0 0
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0000987 core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0001829 trophectodermal cell differentiation Database 0
Category members GO Category GO:0001892 embryonic placenta development Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0030219 megakaryocyte differentiation Database 0
Category members GO Category GO:0032993 protein-DNA complex Database 0
Category members GO Category GO:0035035 histone acetyltransferase binding Database 0
Category members GO Category GO:0035326 enhancer binding Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043353 enucleate erythrocyte differentiation Database 0
Category members GO Category GO:0043425 bHLH transcription factor binding Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048706 embryonic skeletal system development Database 0


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