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Query: MEN1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MEN1 0 -0.747 1.080 -1.150
MEN1 0 -0.747 1.080 -1.150 0.395
MEN1 0 -0.747 1.080 -1.150 0.101 0.684 -0.063

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MEN1 Ubiquitylation K8 -1.132 0.088 _AAQK(gl)TLFPLR_
MEN1 Phosphorylation S218 -0.820 _RES(ph)KPEEPPPPK_

Background Information for MEN1:


Pubmed-MEN1 »
Uniprot-MEN1 »
Biogrid-MEN1 »
ProteomicsDB-MEN1 »

Tumorportal-MEN1 »
COSMIC-MEN1 »
GenomeRNAi-MEN1 »
Genecards-MEN1


Protein-protein Interactions for MEN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP7A Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP2A Cat. description Hein, Mann, Cell 2015
Category members IP bait ERP44 Cat. description Hein, Mann, Cell 2015
Category members IP bait LCK Cat. description Hein, Mann, Cell 2015
Category members IP bait MED12 Cat. description Hein, Mann, Cell 2015
Category members IP bait SET Cat. description Hein, Mann, Cell 2015


Protein Domains in MEN1
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring MEN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1254 Menin-associated histone methyltransferase complex Database 0.35
Category members Corum 1256 MLL-HCF complex Database 0.3


Categories featuring MEN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0032154 cleavage furrow Database 2.01
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0034968 histone lysine methylation Database 1.1
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0045786 negative regulation of cell cycle Database 0.93
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0009411 response to UV Database 0.79
Category members GO Category GO:0018024 histone-lysine N-methyltransferase activity Database 0.73
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members GO Category GO:0045597 positive regulation of cell differentiation Database 0.45
Category members GO Category GO:0045668 negative regulation of osteoblast differentiation Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0035097 histone methyltransferase complex Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0030674 protein binding, bridging Database 0.25
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0000400 four-way junction DNA binding Database 0.2
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0002076 osteoblast development Database 0.13
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members GO Category GO:0016571 histone methylation Database 0.08
Category members Pathway Pathway_808 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION 0 0.08
Category members GO Category GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway Database 0.06
Category members Disease phenotype Multiple_endocrine_neoplasia_type_1 Multiple endocrine neoplasia type 1 Database 0.04
Category members GO Category GO:0001933 negative regulation of protein phosphorylation Database 0.04
Category members GO Category GO:0000403 Y-form DNA binding Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0048704 embryonic skeletal system morphogenesis Database 0
Category members Disease phenotype Familial_isolated_hyperparathyroidism Familial isolated hyperparathyroidism Database 0
Category members Disease phenotype Familial_parathyroid_adenoma Familial parathyroid adenoma Database 0
Category members Disease phenotype HYPERPARATHYROIDISM_1 HYPERPARATHYROIDISM 1 Database 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0001776 leukocyte homeostasis Database 0
Category members GO Category GO:0002051 osteoblast fate commitment Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0031062 positive regulation of histone methylation Database 0
Category members GO Category GO:0032092 positive regulation of protein binding Database 0
Category members GO Category GO:0032925 regulation of activin receptor signaling pathway Database 0
Category members GO Category GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0045669 positive regulation of osteoblast differentiation Database 0
Category members GO Category GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity Database 0
Category members GO Category GO:0046329 negative regulation of JNK cascade Database 0
Category members GO Category GO:0046621 negative regulation of organ growth Database 0
Category members GO Category GO:0051781 positive regulation of cell division Database 0
Category members GO Category GO:0051974 negative regulation of telomerase activity Database 0
Category members GO Category GO:0060135 maternal process involved in female pregnancy Database 0
Category members GO Category GO:0070412 R-SMAD binding Database 0


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