Results for the Category
negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
| RNAi screen result | RNAPII IP (MG132) | CSB IP | CSB IP (MG132) | Chrom. | Chrom. (MG132) | Ubi /Phospo | Ubi /Phospho (MG132) |
| W | |||||||
| Gene name | MGoogle Score | RNAi high | RNAi low | RNAPII-IP (MG132) | CSB-IP | CSB-IP (MG132) | Chrom. | Chrom. (MG132) |
|---|---|---|---|---|---|---|---|---|
| PLK1 | 2 | 3.098 | -0.387 | 0.212 | -1.949 | -0.610 | ||
| TFAP4 | 1 | 1.270 | -0.790 | |||||
| KAT2B | 1 | -0.980 | 2.090 | |||||
| CDK5RAP1 | 0 | -0.230 | 0.000 | |||||
| TNFAIP3 | 0 | 0.760 | -0.500 | |||||
| CDKN1A | 0 | 1.080 | -0.750 | |||||
| LATS1 | 0 | 0.520 | -0.880 | |||||
| MEN1 | 0 | 1.080 | -1.150 | 0.101 | 0.684 | -0.063 | ||
| MEN1 | 0 | 1.080 | -1.150 | 0.395 | ||||
| MEN1 | 0 | 1.080 | -1.150 | |||||
| CDKN2A | 0 | -0.080 | -0.260 | -0.556 | -1.080 | -3.270 | -1.110 | |
| CASP3 | 0 | 0.570 | -0.390 | |||||
| HEXIM2 | 0 | -0.490 | 1.310 | |||||
| NR2F2 | 0 | -1.120 | 1.260 | -1.119 | 0.136 | 0.670 | ||
| NR2F2 | 0 | -1.120 | 1.260 | 0.225 | 0.992 | 0.424 | 0.474 |
| Gene name | PTM type | PTM site | UV | UV (MG132) | Sequence |
|---|---|---|---|---|---|
| CASP3 | Ubiquitylation | K11 | -0.053 | -0.687 | _(ac)MENTENSVDSK(gl)SIK_ |
| CASP3 | Ubiquitylation | K14 | -0.455 | -0.687 | _SIK(gl)NLEPK_ |
| CASP3 | Ubiquitylation | K57 | -0.304 | -1.817 | _NFHK(gl)STGMTSR_ |
| CASP3 | Ubiquitylation | K82 | -0.268 | -0.605 | _NLK(gl)YEVR_ |
| CDK5RAP1 | Ubiquitylation | K189 | -0.716 | _LK(gl)EEILNR_ | |
| CDK5RAP1 | Ubiquitylation | K348 | -1.373 | _GFTTNYKTK(gl)_ | |
| CDK5RAP1 | Ubiquitylation | K396 | -1.590 | _DNICK(gl)QIHLPAQSGSSR_ | |
| CDK5RAP1 | Ubiquitylation | K487 | -1.858 | _LK(gl)DDVPEEVK_ | |
| CDK5RAP1 | Ubiquitylation | K495 | -1.951 | _LKDDVPEEVK(gl)LR_ | |
| CDKN1A | Ubiquitylation | K188 | -2.505 | -1.077 | _QTSMTDFYHSK(gl)R_ |
| HEXIM2 | Phosphorylation | S14 | 0.794 | _(ac)MMATPNQTACNAES(ph)PVALEEAK_ | |
| HEXIM2 | Phosphorylation | S76 | 0.437 | -0.036 | _TQS(ph)PGGCSAEAVLAR_ |
| KAT2B | Phosphorylation | S117 | 2.088 | _NPNPS(ph)PTPPR_ | |
| LATS1 | Phosphorylation | T246 | -2.282 | _SVT(ph)PPPPPR_ | |
| LATS1 | Phosphorylation | T262 | -1.011 | _GTT(ph)PPPPSWEPNSQTK_ | |
| LATS1 | Phosphorylation | S278 | 0.261 | 0.599 | _RYS(ph)GNM(ox)EYVISR_ |
| LATS1 | Phosphorylation | S462 | -0.408 | _S(ph)NSFNNPLGNR_ | |
| LATS1 | Phosphorylation | S464 | 0.077 | -0.151 | _SNS(ph)FNNPLGNR_ |
| LATS1 | Phosphorylation | S613 | 0.270 | 0.155 | _KQITTS(ph)PITVR_ |
| LATS1 | Ubiquitylation | K688 | 0.392 | _MLCQK(gl)ESNYIR_ | |
| MEN1 | Ubiquitylation | K8 | -1.132 | 0.088 | _AAQK(gl)TLFPLR_ |
| MEN1 | Phosphorylation | S218 | -0.820 | _RES(ph)KPEEPPPPK_ | |
| NR2F2 | Ubiquitylation | K362 | 0.144 | _FGK(gl)LLLR_ | |
| NR2F2 | Ubiquitylation | K389 | -0.473 | -0.156 | _LVGK(gl)TPIETLIR_ |
| PLK1 | Ubiquitylation | K358 | -2.258 | _EK(gl)EEPVVR_ | |
| PLK1 | Ubiquitylation | K574 | 1.656 | _LSLLEEYGCCK(gl)ELASR_ | |
| TFAP4 | Ubiquitylation | K114 | 1.008 | 2.315 | _LLQQNTQLK(gl)R_ |
| TFAP4 | Phosphorylation | S123 | 0.832 | _RFIQELSGS(ph)SPKR_ | |
| TFAP4 | Phosphorylation | S124 | 0.584 | 0.494 | _RFIQELSGSS(ph)PK_ |
| TNFAIP3 | Ubiquitylation | K722 | 0.496 | 0.176 | _ASCK(gl)NILACR_ |
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