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Query: TFAP4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TFAP4 1 4.740 1.270 -0.790

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TFAP4 Ubiquitylation K114 1.008 2.315 _LLQQNTQLK(gl)R_
TFAP4 Phosphorylation S123 0.832 _RFIQELSGS(ph)SPKR_
TFAP4 Phosphorylation S124 0.584 0.494 _RFIQELSGSS(ph)PK_

Background Information for TFAP4:


Pubmed-TFAP4 »
Uniprot-TFAP4 »
Biogrid-TFAP4 »
ProteomicsDB-TFAP4 »

Tumorportal-TFAP4 »
COSMIC-TFAP4 »
GenomeRNAi-TFAP4 »
Genecards-TFAP4


Protein-protein Interactions for TFAP4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDKN2AIP Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXW11 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEU2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFAP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TFAP4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bHLH_dom IPR011598 0.32


Protein complexes (CORUM database) featuring TFAP4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TFAP4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0043923 positive regulation by host of viral transcription Database 0.27
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0043922 negative regulation by host of viral transcription Database 0.12
Category members GO Category GO:0043392 negative regulation of DNA binding Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0070888 E-box binding Database 0
Category members GO Category GO:0071157 negative regulation of cell cycle arrest Database 0


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